Paracoccidioidomycosis: clinical and epidemiological studies of cases observed in the course of 25 years, in Mato Grosso do Sul, Brazil

Abstract

Paracoccidioidomycosis (PCM) clinical and epidemiological characteristics, uncommon clinical manifestations and association with AIDS in the state of Mato Grosso do Sul, Brazil, were studied, resulting in five reports of cases observed during 25 years at the University Hospital of the Federal University of Mato Grosso do Sul (UFMS). We studied the clinical and epidemiological features of 422 PCM cases attended at the University Hospital of the UFMS. Mean age was 43.4 years old and the man:woman proportion was 10:1. The acute/subacute form (15.6%) presented mainly with lymphadenopathy (95.4%) and the chronic form (86.4%) showed mainly involvement of the lungs (87.3%) and oropharynx (66.4%). Sulfamethoxazole/trimethoprim association was used in 90.3% of the patients. Sequelae were observed in 30.3% and death occurred in 7.6% cases. Twelve cases of PCM associated with AIDS were analyzed. The mean age was 36.1 years old and most of the patients had a diagnosis other than PCM as the AIDSdefining illness. Seven patients (58.3%) showed involvement of more than one extrapulmonary organ. The most often involved organs were: lymph nodes (83.3%), lung (58.3%), skin (50%), and oral mucous membrane (41.6%). Eight patients died with progressive PCM manifestations. These data reinforce that PCM behaves as an opportunistic disease in AIDS patients. The study of 13 cases of neuroPCM demonstrated that paresis (8/13), headache (5/13), and dizziness (4/13) were the most frequent neurological manifestations. Two patients had exclusive lesions in the central nervous system. The neuroimaging diagnosis showed predominance of multiple and round annular-enhancing lesions after contrast injection. Lesions were seen in brain hemispheres (9/13), thalamus (9/13), cerebellum (4/13), brainstem (4/13), and spinal cord (4/13). The majority of cases presented good therapeutic response with sulfamethoxazole/trimethoprim. The study of 10 patients with osteoarticular PCM showed that the most frequent clinical manifestations were: pain (10/10), tumor (7/10), and redness (6/10) of the compromised region. Radiographs revealed osteolytic lesions in all patients and the majority presented multiple and bilateral lesions. A case of erythema nodosum associated with PCM was diagnosed for the first time.

Perfil clínico-epidemiológico dos pacientes portadores de paracoccidioidomicose no Serviço de Estomatologia do Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul

“…De acordo com nossos resultados, o tabagismo exclusivo foi verificado em 39,4% dos pacientes, e esse hábito associado ao etilismo, estava presente em 45,9% dos casos. Há um indicativo que o tabagismo apresenta alta prevalência (90,3%) entre os portadores de PCM 18 .…”

“…O aspecto clínico característico de estomatite moriforme, foi uma freqüente manifestação estomatológica da doença na nossa amostra, assim como em outros estudos 7 23 . Em nosso Serviço, por ser especializado em Estomatologia, 100% dos casos apresentaram lesões orais, que ocorreram na forma crônica da doença 18 . Em outra casuística, os sítios anatômicos observados em 70% dos prontuários de pacientes foram o processo alveolar e gengiva, seguido do palato; e em 30% desses verificou-se a presença de lesões múltiplas.…”

Occurrence of 102 cases of paracoccidioidomycosis in 18 months in the Itaipu Lake region, Western Paraná

“…8 . The high number of new cases per year in this study is due to the fact that mycological examination of sputum for PCM is part of the routine for all the patients attending the Tuberculosis Division of the Epidemiological Surveillance of Foz do Iguaçu.…”

Dissociação clínico-radiológica nas manifestações pulmonares da paracoccidioidomicose

“…O diagnóstico precoce da paracoccidioidomicose é importante, a fim de evitar as formas mais avançadas e mutilantes da doença, pois as lesões pulmonares produzidas por Paracoccidioides brasiliensis têm tendência evolutiva, determinando fibrose residual 19 , a seqüela mais incapacitante da doença 14 . Além disso, com o processo de envelhecimento, a sintomatologia respiratória e o declínio da função pulmonar tendem a piorar gradativamente 15 .…”

“…Este hábito é altamente prevalente entre os portadores da paracoccidioidomicose 14 e é considerado um fator de risco para o desenvolvimento da doença 17 .…”