Immune response to Rhodococcus equi infection in high and low antibody-producer mice (selection IV-A)

Pedrini, Silvia

doi:10.1590/s1678-91992005000400024

Cited by 2 publications

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“…For example, there was an increased incidence of arthritis in response to Mycoplasma hyorhinis infection in Yorkshire pigs selected for both 'high' immune response accompanied by increased weight gain compared to contemporaneous pigs selected for both 'low' immune response accompanied by decreased weight gain (Jayagopala Reddy et al, 2000). In another study, selecting mice for a high antibody response was associated with either an enhanced or reduced ability to respond to an infection depending on the type of pathogen involved (Gheorgiou et al, 1985;Pedrini et al, 2005). Selection responses should be monitored to ensure that such effects do not arise.…”

Section: Discussionmentioning

confidence: 99%

Pig peripheral blood mononuclear leucocyte subsets are heritable and genetically correlated with performance

Clapperton

Glass

Bishop

2008

Animal

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Indicator traits used to select pigs for increased resistance to infection or improved health must be heritable and, preferably, be associated with improved performance. We estimated the heritability of a range of immune traits and their genetic and phenotypic correlations with growth performance. We measured immune traits on 589 pigs and performance on 1941 pigs from six farms, three of which were classified as 'high health status' (i.e. specific pathogen-free) and three were of lower health status. All pigs were apparently healthy. Immune traits were total white blood cells (WBC), and peripheral blood mononuclear leucocyte (PBML) subsets positive for CD4, CD8a, gamma delta (gd) T cell receptor, CD11R1 (natural killer cell marker), B cell and monocyte markers at the start and the end of standard growth performance tests. At both time points, all immune traits were moderately to highly heritable except for CD8a 1 cells. At end of test, heritability estimates (h 2 ) (6s.e.) were 0.18 (60.11) for total WBC count. For PBML subset proportions, the heritabilities were 0.52 (60.14) for gd TCR 1 cells, 0.62 (60.14) for CD4 1 cells, 0.44 (60.14) for CD11R1 1 cells, 0.58 (60.14) for B cells and 0.59 (60.14) for monocytes. Farm health status affected the heritabilities for WBC, being substantially higher on lower health status farms, but did not have consistent effects on heritabilities for the PBML subsets. There were significant negative genetic correlations between numbers and proportions of various PBML subsets and performance, at both start and end of test. In particular, the proportion of PBML cells that were CD11R1 1 cells, at end of test, was strongly correlated with daily gain (r g 5 20.72; P , 0.01). There were also weaker but significant negative phenotypic correlations between PBML subsets measured at end of test and performance, for gd 1 T cells, CD8a 1 , CD11R1 1 cells, B cells or monocytes. Phenotypic correlations with daily gain were generally lower at the start of test than at the end of test. These results show that most of the major pig PBML subsets are heritable, and that systemic levels of several of these PBML subsets are genetically negatively correlated with performance. This approach provides a basis for using immune trait markers when selecting boars that can produce higher-performing progeny.

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Section: Discussionmentioning

confidence: 99%

Pig peripheral blood mononuclear leucocyte subsets are heritable and genetically correlated with performance

Clapperton

Glass

Bishop

2008

Animal

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“…Furthermore, varying degrees of sensitivities to bacterial infection were identified in different mouse lines, which were selectively established according to the immunological phenotype (Araujo et al . 1998; Pedrini et al . 2005).…”

Section: Discussionmentioning

confidence: 99%

Immunological characteristics and response to lipopolysaccharide of mouse lines selectively bred with natural and acquired immunities

Narahara¹,

Sakai²,

Katayama³

et al. 2011

Animal Science Journal

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Genetic improvement of resistance to infectious diseases is a challenging goal in animal breeding. Infection resistance involves multiple immunological characteristics, including natural and acquired immunity. In the present study, we developed an experimental model based on genetic selection, to improve immunological phenotypes. We selectively established three mouse lines based on phagocytic activity, antibody production and the combination of these two phenotypes. We analyzed the immunological characteristics of these lines using a lipopolysaccharide (LPS), which is one of the main components of Gram-negative bacteria. An intense immunological reaction was induced in each of the three mouse lines. Severe loss of body weight and liver damage were observed, and a high level of cytokine messenger RNA was detected in the liver tissue. The mouse line established using a combination of the two selection standards showed unique characteristics relative to the mouse lines selected on the basis of a single phenotype. Our results indicate that genetic selection and breeding is effective, even for immunological phenotypes with a relatively low heritability. Thus, it may be possible to improve resistance to infectious diseases by means of genetic selection.

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Immune response to Rhodococcus equi infection in high and low antibody-producer mice (selection IV-A)

Cited by 2 publications

References 0 publications

Pig peripheral blood mononuclear leucocyte subsets are heritable and genetically correlated with performance

Pig peripheral blood mononuclear leucocyte subsets are heritable and genetically correlated with performance

Immunological characteristics and response to lipopolysaccharide of mouse lines selectively bred with natural and acquired immunities

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