Anticaries effect of dentifrices with calcium citrate and sodium trimetaphosphate

Abstract

Because of the growing concerns regarding fluoride ingestion by young children and dental fluorosis, it is necessary to develop new dentifrices.ObjectiveThe aim of this study was to evaluate the effect of dentifrices with calcium citrate (Cacit) and sodium trimetaphosphate (TMP) on enamel demineralization. Material and MethodsEnamel blocks (n=70), previously selected through surface hardness analysis, were submitted to daily treatment with dentifrices diluted in artificial saliva and to a pH-cycling model. The fluoride concentration in dentifrices was 0, 250, 450, 550, 1,000 and 1,100 µg F/g. CrestTM was used as a positive control (1,100 mg F/g). Cacit (0.25%) and TMP (0.25%) were added to dentifrices with 450 and 1,000 µg F/g. Surface hardness was measured again and integrated loss of subsurface hardness and fluoride concentration in enamel were calculated. Parametric and correlation tests were used to determine difference (p<0.05) and dose-response relationship between treatments. ResultsThe addition of Cacit and TMP did not provide a higher fluoride concentration in enamel, however it reduced (p<0.05) mineral loss when compared to other dentifrices; the dentifrice with Cacit and TMP and a low fluoride concentration presented similar results when compared to a dentifrice with 1,100 mg F/g (p>0.05). ConclusionsDentifrices with 450 and 1,000 µg F/g, Cacit and TMP were as effective as a gold standard one.

Fluoride and sodium trimetaphosphate (TMP) release from fluoride varnishes supplemented with TMP

“…For TMP determination, the solutions were hydrolyzed with 1 mol/L HCl, at a temperature just below boiling point. 6 Total phosphorus was then determined using a colorimeter (EON Biotek, Winooski, USA). 7 …”

Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study

“…The study comprised 4 experimental phases of 3 days each, with a 7-day washout period between the experimental phases. Enamel blocks (4 × 4 mm, n = 176) from bovine incisors were stored in 2% formaldehyde solution (pH 7.0) for 30 days at room temperature [White and Featherstone, 1987;Delbem et al, 2012] ( fig. 1 a).…”

“…Sodium trimetaphosphate (TMP) is a condensed inorganic phosphate that was shown to increase the effects of a low-F toothpaste against enamel demineralization [Takeshita et al, 2009[Takeshita et al, , 2011Delbem et al, 2012;Takeshita et al, 2015] as well as to promote significantly lower caries increments in children when compared with a conventional (1,100 ppm F) toothpaste [Freire et al, 2016]. Although the effect of TMP upon an acid challenge is based on its capacity to adsorb on enamel and increase calcium, phosphate and fluoride incorporation [Takeshita et al, 2009[Takeshita et al, , 2011Delbem et al, 2012;Takeshita et al, 2015], few data are available on the effects of TMP on enamel remineralization.…”

“…Although the effect of TMP upon an acid challenge is based on its capacity to adsorb on enamel and increase calcium, phosphate and fluoride incorporation [Takeshita et al, 2009[Takeshita et al, , 2011Delbem et al, 2012;Takeshita et al, 2015], few data are available on the effects of TMP on enamel remineralization. This is paramount from a clinical point of view, given that toothpastes are used not only as a preventive measure (i.e.…”

Noninvasive Dentistry: A Dream or Reality?

“…In recent years interest in TMP has been renewed as a possible way of reducing the fluoride content of dentifrices. Several in vitro studies [Takeshita et al, 2009;Delbem et al, 2012;Favretto et al, 2013] demonstrated that adding TMP to a fluoride regime resulted in enhanced efficacy of low F groups, indicating that a combination of TMP and F would allow for lowering F concentrations without losing efficacy, but currently no clinical data supporting these in vitro findings is available.…”