Platelet-rich plasma plus bioactive glass in the treatment of intra-bony defects: a study in dogs

Carvalho, Marcelo Diniz; Suaid, Fabricia Ferreira; Santamaria, Milton; Casati, Márcio Zaffalon; Nociti, Francisco Humberto; Sallum, Antônio Wilson; Sallum, Enílson Antônio

doi:10.1590/s1678-77572011000100016

Cited by 18 publications

(11 citation statements)

References 28 publications

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“…BG has become an alternative to autologous and allogeneic bone grafts, and has been employed in various clinical and animal studies (4,14,(18)(19)(20)(21)(22)(23)26). As shown by some previous authors (32,53), in the present study, no foreign body reaction was observed in the histological specimens, which even showed intense activity and areas of new bone formation, especially at the edge of the defects. These results imply that BG is biocompatible with the surrounding tissues.…”

Section: Discussionsupporting

confidence: 71%

“…With regard to clinical applications, other studies have used PRP in association with some bone substitutes, such as chitosan (28), particulate bone grafts (29)(30)(31), anorganic bovine bone allografts (1,3,17) and bioactive glass (32). Bioactive glass (BG) is a type of bioactive ceramic that has also been used in some studies to enhance bone formation (4,(32)(33)(34)(35). Demir et al (4) tested a combination of BG and platelet-rich plasma for use in bone defects, and suggested that both the PRP/ BG combination and BG alone were effective.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of bioactive glass and platelet-rich plasma for bone healing in rabbit calvarial defects

Penteado

Colombo

Penteado³

et al. 2013

J Oral Sci

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Bone regeneration is an important objective in clinical dental practice and has been used for different applications. The aim of this study was to evaluate the effectiveness of platelet-rich plasma (PRP) and bioactive glass (BG) for bone healing of surgical calvarial defects in rabbits. Two 8-mm defects were prepared in the parietal bones of ten animals, and the animals were randomly assigned to two groups. In each group, two subgroups were created with five defects each: BC - blood clot, BG, PRP and PRP + BG. Thus, four treatments were performed with five specimens each. The animals were sacrificed after 12 weeks and the specimens were analyzed radiographically, histologically and histomorphometrically. Data were subjected to ANOVA and Tukey's tests (α = 0.05). Outcomes demonstrated that the PRP group had higher bone density (%) values than the groups not treated with PRP (P < 0.05). Histometrically, both groups treated with PRP (PRP: 25.6 ± 9.9; PRP+BG: 25.8 ± 12.4) demonstrated higher percentages of new bone formation than the groups not treated with PRP (BG: 6.1 ± 4.3; BC: 7.8 ± 5.6) (P < 0.05). The results suggested that PRP improved bone repair and that bioactive glass alone, or in association with PRP, did not improve bone healing.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Evaluation of bioactive glass and platelet-rich plasma for bone healing in rabbit calvarial defects

Penteado

Colombo

Penteado³

et al. 2013

J Oral Sci

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“…Other studies have described the effects of the combination of bone grafts with bioactive molecules in the regeneration of periodontal defects . Platelet‐rich plasma (PRP) is a preparation of autologous plasma that contains a higher platelet concentration, allowing the delivery of a variable concentration of autologous growth factors such as PDGF and TGF‐β, which regulate cell proliferation, chemotaxis and differentiation.…”

Section: Growth/differentiation Factors and Enamel Matrix Derivativementioning

confidence: 99%

Experimental and clinical studies on regenerative periodontal therapy

Sallum

Ribeiro

Ruiz

et al. 2019

Periodontology 2000

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bone substitutes, enamel matrix proteins, guided tissue regeneration, periodontal, regeneration, tissue engineering | INTRODUC TI ONThe purpose of this chapter of Periodontology 2000 is to review the research carried out in Latin America in the field of periodontal regeneration, focusing mainly on studies using preclinical models (animal models) and randomized controlled clinical trials. It has been organized to reflect the information produced by Latin American research groups, which are accompanied by the appropriate references. The specific questions raised by these groups were explored in each subtopic, based on the results. Therefore, a complete review of this topic is not within the scope of this text as other reviews covering regenerative therapies are available in the literature. [1][2][3][4][5][6][7][8]

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“…Dutra et al [ 34 ] demonstrated that bioactive glass associated with PRP gave rise to a more mature bone formation. However, some researchers asserted that PRP did not have additional influence on periodontal and bone regeneration [ 35 , 36 ]. Demir et al [ 37 ] reported that the addition of PRP to a bioactive glass graft material did not make significant improvements on the treatment of intra-bony defects in clinical studies.…”

Section: Resultsmentioning

confidence: 99%

Effect of Platelet-Rich Plasma and Bioactive Glass Powder for the Improvement of Rotator Cuff Tendon-to-Bone Healing in a Rabbit Model

Dong

Chen

et al. 2014

IJMS

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To test the hypothesis that a platelet-rich plasma (PRP) plus bioactive glass (BG) mixture could shorten the tendon-bone healing process in rotator cuff tendon repair, thirty mature male New Zealand white rabbits were randomly divided into three groups, Control, PRP, and PRP + BG. All groups underwent a surgical procedure to establish a rotator cuff tendon healing model. Mechanical examinations and histological assays were taken to verify the adhesion of the tendon-bone. Real-time PCR was adopted to analyze Bone Morphogenetic Protein-2 (BMP-2). The maximum load-to-failure value in mechanical examinations was significantly higher in the PRP + BG group than that in the control group after six weeks (Control 38.73 ± 8.58, PRP 54.49 ± 8.72, PRP + BG 79.15 ± 7.62, p < 0.001), but it was not significantly different at 12 weeks (PRP 74.27 ± 7.74, PRP + BG 82.57 ± 6.63, p = 0.145). In histological assays, H&E (hematoxylin-eosin) staining showed that the interface between the tendon-bone integration was much sturdier in the PRP + BG group compared to the other two groups at each time point, and more ordered arranged tendon fibers can be seen at 12 weeks. At six weeks, the mRNA expression levels of BMP-2 in the PRP + BG group were higher than those in the other groups (PRP + BG 0.65 ± 0.11, PRP 2.284 ± 0.07, Control 0.12 ± 0.05, p < 0.05). However, there was no significant difference in the mRNA expression levels of BMP-2 among the three groups at 12 weeks (p = 0.922, 0.067, 0.056). BMP-2 levels in PRP and PRP+BG groups were significantly lower at 12 weeks compared to six weeks (p = 0.006, <0.001).We found that the PRP + BG mixture could enhance tendon-bone healing in rotator cuff tendon repair.

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Platelet-rich plasma plus bioactive glass in the treatment of intra-bony defects: a study in dogs

Cited by 18 publications

References 28 publications

Evaluation of bioactive glass and platelet-rich plasma for bone healing in rabbit calvarial defects

Evaluation of bioactive glass and platelet-rich plasma for bone healing in rabbit calvarial defects

Experimental and clinical studies on regenerative periodontal therapy

Effect of Platelet-Rich Plasma and Bioactive Glass Powder for the Improvement of Rotator Cuff Tendon-to-Bone Healing in a Rabbit Model

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