Clinical and antimicrobial efficacy of NitrAdineTM-based disinfecting cleaning tablets in complete denture wearers

Abstract

ObjectiveThis study evaluated the efficacy of NitrAdineTM-based disinfecting cleaning tablets for complete denture, in terms of denture biofilm removal and antimicrobial action. Material and methodsForty complete denture wearers (14 men and 26 women) with a mean age of 62.3±9.0 years were randomly assigned to two groups and were instructed to clean their dentures according to two methods: brushing (control) - 3 times a day with denture brush and tap water following meals; brushing and immersion (experimental) - brushing the denture 3 times a day with denture brush and tap water following meals and immersion of the denture in NitrAdineTM-based denture tablets (Medical InterporousTM). Each method was used for 21 days. Denture biofilm was disclosed by a 1% neutral red solution and quantified by means of digital photos taken from the internal surface before and after the use of the product. Microbiological assessment was conducted to quantify Candida sp. ResultsAn independent t-test revealed a significant lower biofilm percentage for the experimental group (4.7, 95% CI 2.4 to 7.9) in comparison with the control group (mean 37.5, 95% CI 28.2 to 48.1) (t38=7.996, p<0.001). A significant reduction of yeast colony forming units could be found after treatment with Medical InterporousTM denture tablets as compared to the control group (Mann-Whitney test, Z=1.90; p<0.05). ConclusionThe present findings suggest that NitrAdineTM-based disinfecting cleaning tablets are efficient in removal of denture biofilm. In addition, a clear antimicrobial action was demonstrated. Therefore, they should be recommended as a routine denture maintenance method for the prevention of the development of microbial biofilm-induced denture stomatitis.

Effects of Denture Cleansers on Heat-Polymerized Acrylic Resin: A Five-Year-Simulated Period of Use

“…Effervescent tablets have been employed in different periods of immersion (7,8,15,18,19) (3,6,11,16). The work hypothesis was rejected since the immersion solutions influenced the properties of acrylic resin.…”

“…Alkaline peroxides are composed by oxidant, effervescent, surface tension reducers and chelating agents commonly found in tablet or powder forms, which in contact with water become hydrogen peroxide solutions (1). Some studies indicated that the association of alkaline peroxide to brushing improved the effectiveness of hygiene (7,8).…”

Bactericidal Effects of a Prosthesis Cleaning Tablet

“…Previous studies have shown that as the complete acrylic removable denture gets older, it becomes harder to remove the biofilms from its surface due to the increased surface roughness as well as the change in the acryl nature (1,19). Therefore, immersion of complete dentures in soluble containing cleaning tablets for 15 minutes can only be effective on newly-formed biofilms (less than 24 hours).…”

“…The number of people who have this problem is growing due to the increasing world population age. Complete denture replacement is one of the most common treatments for this problem (1). Complete denture replacement changes the bacterial flora of the mouth, and since this treatment is used mostly in elderly patients with low physical abilities and low immunity and those who usually have systemic diseases requiring medical treatments, it changes the balance of mouth microflora and increases the colony forming unit (CFU), and thus, may cause oral infections (1-6).…”

Protez Temi̇zleyi̇ci̇ Solüsyonlarin Isi İle Poli̇meri̇ze Olan Akri̇li̇k Rezi̇ni̇n Mi̇krosertli̇ği̇ne Etki̇si̇

“…Çalışmalarda solüsyon-larda bekletme süresi 5 dakikadan sekiz saate kadar değişmektedir. 12,14,16,18,19 Bu çalışmada sonuçları karşı-laştırabilmek için tüm solüsyonlarda eşit bekletme süresi seçilmiştir. 10,20 Çalışmada Grup 3 (%1 NaOCl) hariç diğer gruplarda 720 daldırma sonunda mikrosertlik değerinde istatistiksel olarak anlamlı olmasa da azalma, Grup 4 (Alkalin peroksit tablet) de ise istatistiksel olarak anlamlı azalma görülmüştür.…”