Guest editorial: understanding dental pulp innate immunity - a basis for identifying new targets for therapeutic agents that dampen inflammation

Farges, Jean‐Christophe

doi:10.1590/s1678-77572009000300001

Cited by 12 publications

(11 citation statements)

References 4 publications

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“…3 An in vitro research on odontoblasts exposed to LTA binding TLR2 even shows that the increasing of the odontoblasts can activate the transcription factor of NF-kb, so it will diffuse from the cytoplasm to the nucleus and then secrete proinflamatory cytokines. 7 Thus, all of these conditions then potentially lead to the inflammation of the pulp.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, with a better understanding of molecular mechanisms in odontoblast-like cells exposed to the bacteria, the effective therapeutic components that modulate pulp cell can also be designed to contribute in healing and repairing processes through the formation of reparative dentin. 7 The formation of reparative dentin is usually started with the binding of progenitor cells into the pulp cells differentiated into odontoblast-like cells and migrated to the injury area.…”

Section: Resultsmentioning

confidence: 99%

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The expressions of NF-kb and TGFb-1 on odontoblast-like cells of human dental pulp injected with propolis extracts

Widjiastuti

Suardita

Saraswati

2014

Dent. J. (Majalah Kedokteran Gigi)

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The expressions of NF-kb and TGFb-1 on odontoblast-like cells of human dental pulp injected with propolis extracts

Widjiastuti

Suardita

Saraswati

2014

Dent. J. (Majalah Kedokteran Gigi)

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“…Despite T cell subpopulations, other immune cells also play an important role in tooth development [35]. Since the proportion of neutrophil was profoundly larger than remaining immune cells (Fig.…”

Section: Non-t Immune Cell Subpopulations and Their Intercellular Interaction Patternsmentioning

confidence: 99%

A Single-cell Interactome of Human Tooth Germ Elucidates Signaling Networks Regulating Dental Development

Shi¹,

Yu²,

Zhang³

et al. 2021

Preprint

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Background: Development of dental tissue is regulated by extensive cell crosstalk based on various signaling molecules, such as BMP, FGF and SHH pathways. However, an intact network of the intercellular regulation is still lacking.Result: To gain an unbiased and comprehensive view of this dental cell interactome, we applied single-cell RNA-seq on immature human tooth germ of the third molar, discovered refined cell subtypes, and applied multiple network analysis to identify the central signaling pathways. We found that immune cells made up over 80% of all tooth germ cells, which exhibited profound regulation on dental cells via TGF-β, TNF and IL-1. During osteoblast differentiation, expression of genes related to extracellular matrix and mineralization was continuously elevated by signals from BMP and FGF family. As for the self-renewal of apical papilla stem cell, BMP-FGFR1-MSX1 pathway directly regulated the G0-to-S cell cycle transition. We also confirmed that CSF1 secreted from pericyte and TNFSF11 secreted from osteoblast regulated a large proportion of genes related to osteoclast transformation from macrophage and monocyte. Conclusion: We constructed the intercellular signaling networks that regulated the essential developmental process of human tooth, which served as a foundation for future dental regeneration engineering and the understanding of oral pathology.

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“…Dental pulp is a soft tissue comprising nerves, blood vessels, lymphatic vessels, connective tissue, and various types of cells within a tooth [ 1 ]. Moreover, it includes several antibacterial substances, hormones, and immune cells that protect the teeth from external invasive bacteria or irritants and prevent the accumulation of extrinsic bacteria or substances inside the dental pulp [ 2 , 3 ]. Aging and stress-related conditions such as inflammation cause dental pulp cell senescence, leading to the aging of the pulp tissue and impaired tooth protection [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

FK866 Protects Human Dental Pulp Cells against Oxidative Stress-Induced Cellular Senescence

Park

Jang

et al. 2021

Antioxidants

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FK866 possesses various functional properties, such as anti-angiogenic, anti-cancer, and anti-inflammatory activities. We previously demonstrated that premature senescence of human dental pulp cells (hDPCs) was induced by hydrogen peroxide (H2O2). The present study aimed to investigate whether H2O2-induced premature senescence of hDPCs is affected by treatment with FK866. We found that FK866 markedly inhibited the senescent characteristics of hDPCs after exposure to H2O2, as revealed by an increase in the number of senescence-associated β-galactosidase (SA-β-gal)-positive hDPCs and the upregulation of the p21 and p53 proteins, which acts as molecular indicators of cellular senescence. Moreover, the stimulatory effects of H2O2 on cellular senescence are associated with oxidative stress induction, such as excessive ROS production and NADPH consumption, telomere DNA damage induction, and upregulation of senescence-associated secretory phenotype factors (IL-1β, IL-6, IL-8, COX-2, and TNF-α) as well as NF-κB activation, which were all blocked by FK866. Thus, FK866 might antagonize H2O2-induced premature senescence of hDPCs, acting as a potential therapeutic antioxidant by attenuating oxidative stress-induced pathologies in dental pulp, including inflammation and cellular senescence.

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Guest editorial: understanding dental pulp innate immunity - a basis for identifying new targets for therapeutic agents that dampen inflammation

Cited by 12 publications

References 4 publications

The expressions of NF-kb and TGFb-1 on odontoblast-like cells of human dental pulp injected with propolis extracts

The expressions of NF-kb and TGFb-1 on odontoblast-like cells of human dental pulp injected with propolis extracts

A Single-cell Interactome of Human Tooth Germ Elucidates Signaling Networks Regulating Dental Development

FK866 Protects Human Dental Pulp Cells against Oxidative Stress-Induced Cellular Senescence

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