Evaluation of surgical cavities filled with three types of calcium sulfate

Abstract

The aim of this study was to evaluate histologically, three types of calcium sulfate - Merck (Brazil), Surgiplaster (Italy) and Capset (USA) - in surgically created defects on rabbit femurs. Twenty male New Zealand rabbits were used. Two surgical bone defects (5 mm diameter x 8 mm depth) were created on each distal epiphysis using a #3 Dentoflex trephine bur. Defects were filled with: group 1 - di-hydrated calcium sulfate (Merck); group 2 - Capset (Lifecore-USA); group 3 - Surgiplaster (Classimport-Italy); group 4 – control (blood clot). The animals were sacrificed 30, 60, 90 and 180 days postoperatively. Semi-serial 6-mm-thick sections were obtained, stained with hematoxylin and eosin and examined under light microscopy. Bone defects treated with calcium sulfate exhibited new bone formation regardless of the product trademark.

Cytotoxicity and migration of fibroblasts on two types of calcium sulfate dihydrate

“…The purified raw material of calcium sulfate dihydrate for medical application is inexpensive. Furthermore, the material has to be sterilized by a suitable method, such as gamma radiation at 25 kGy, before use in surgical procedure . Therefore, this can reduce the cost of treatment, which gives patients greater opportunity for proper treatment.…”

“…5,[13][14][15] Another form of calcium sulfate that has been demonstrated for regenerative capacity in animal models is calcium sulfate dihydrate. 16,17 Calcium sulfate dihydrate has shown promise as a resorbable barrier in a socket preservation and guided bone regeneration. 18,19 The purified raw material of calcium sulfate dihydrate for medical application is inexpensive.…”

Nanocalcium sulfate and collagen biomaterials: Effects on osteoblastic cells

“…Calcium sulfate has been used in medicine and dentistry for more than 100 years and has been proven to be a biocompatible material [3]. It has been extensively studied in numerous animal models and has been shown to allow bone tissue growth in osseous defects [6] with timely resorption of the calcium sulfate [3,16]. When used as a bone graft, calcium sulfate has been shown to result in new bone formation in human extraction sockets after 3 months [17].…”

Estudo do processo de reparo ósseo em função de quatro biomateriais. Avaliação histomorfológica em tíbia de coelhos

“…Dessa forma o uso de enxertos ósseos pode colaborar com o processo de reparo. Na presença de enxertos ósseos, o mecanismo reparador descrito se desenvolve normalmente, desde que o material utilizado não seja citotóxico (PECORA, et al, 1997;AABOE, et al, 2000;APAYDIN;TORABINEJAD, 2004;BETTI, 2004;MAEDA, et al, 2007).…”

“…xenógenos são obtidos de uma espécie diferente do receptor. E os aloplásticos, que são materiais de origem inorgânica ou sintéticos (PECORA, et al, 1997;HOSOKAWA, et al, 1999;HOEXTER, 2002;BETTI, 2004;DA CRUZ, et al, 2007;MAEDA, et al, 2007;CALASANS-MAIA, et al, 2009).…”