Antioxidant supplementation decreases the cell death rate in the prostatic stromal tissue of long-term castrated rats

Fartes, Guilherme; Lorenzetti, Fábio; Salvador, L; Ortiz, Valdemar; Dambros, Míriam

doi:10.1590/s1677-55382012000300016

Cited by 2 publications

(2 citation statements)

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“…Castration was known to induce oxidative stress in many tissues, such as those in the prostate, bladder and urethral sphincter complex. [23][24][25] Oxidative stress was reported to induce penile structural alternation, which was defined as the increase in collagen deposition and fibrosis in another study using a diabetic model. 26 In the present study, castration might L-Cit effects on penile erection and structure have caused oxidative stress in the penile tissues and fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…Whereas castration decreased the SM‐to‐collagen ratios, the oral l ‐Cit supplementation improved the SM‐to‐collagen ratio. Castration was known to induce oxidative stress in many tissues, such as those in the prostate, bladder and urethral sphincter complex . Oxidative stress was reported to induce penile structural alternation, which was defined as the increase in collagen deposition and fibrosis in another study using a diabetic model .…”

Section: Discussionmentioning

confidence: 99%

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Oral l‐citrulline supplementation improves erectile function and penile structure in castrated rats

et al. 2013

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Abbreviations & AcronymsObjectives: To investigate the efficacy of oral L-citrulline for erectile dysfunction and penile structure disruption in a rat model. Methods: Male Wistar-ST rats aged 15 weeks were randomly divided into three groups as follows: sham-operated rats (control group), surgically castrated rats (castrated group) and surgically castrated rats subsequently treated with 2% L-citrulline water (castrated + Lcitrulline). At 4 weeks postoperative, erectile function was assessed based on intracavernous pressure changes, followed by electrostimulation of cavernous nerves and calculation of maximum intracavernous pressure/mean arterial pressure. Penile structure was evaluated by Masson's trichrome staining and the smooth muscle-to-collagen ratio was calculated. The serum bioavailable testosterone, L-arginine, L-citrulline, N G ,N G -dimethylarginine and nitrogen oxide levels were evaluated. Results: The bioavailable testosterone concentrations were decreased in the castrated and castrated + L-citrulline groups compared with the control group at 4 weeks after surgery. The intracavernous pressure-to-mean arterial pressure and smooth muscle-to-collagen ratios were significantly decreased in the castrated group compared with the control group, but significantly increased in the castrated + L-citrulline group compared with the castrated group. The serum L-citrulline, L-arginine and N G ,N G -dimethylarginine levels, and the L-arginineto-N G ,N G -dimethylarginine ratios were significantly increased in the castrated + L-citrulline group compared with the castrated group. The serum nitrogen oxide levels were increased in the castrated + L-citrulline group compared with the castrated group. Conclusions: Oral L-citrulline can improve the erectile response to electric stimulation of cavernous nerve and penile structure in castrated rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oral l‐citrulline supplementation improves erectile function and penile structure in castrated rats

et al. 2013

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Effect of some antioxidants on the prostate of adult and aged albino rats: a histological and immunohistochemical study

Gabry¹,

Kader²,

Moustafa³

et al. 2014

j app pharm sci

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Antioxidant supplementation decreases the cell death rate in the prostatic stromal tissue of long-term castrated rats

Abstract: ARTIcLe InfO ___________________________________________ _

Cited by 2 publications

References 24 publications

Oral l‐citrulline supplementation improves erectile function and penile structure in castrated rats

Oral l‐citrulline supplementation improves erectile function and penile structure in castrated rats

Effect of some antioxidants on the prostate of adult and aged albino rats: a histological and immunohistochemical study

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Antioxidant supplementation decreases the cell death rate in the prostatic stromal tissue of long-term castrated rats

Abstract: ARTIcLe InfO _______________________________________________________________ _____________________

Cited by 2 publications

References 24 publications

Oral l‐citrulline supplementation improves erectile function and penile structure in castrated rats

Oral l‐citrulline supplementation improves erectile function and penile structure in castrated rats

Effect of some antioxidants on the prostate of adult and aged albino rats: a histological and immunohistochemical study

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Abstract: ARTIcLe InfO ___________________________________________ _