Comparison of the efficacy and safety of topical diltiazem and nitroglycerine for pain relief during transrectal ultrasound guided biopsy of the prostate

Evaluation of the efficacy of a combination of diltiazem and periprostatic nerve block in pain control during transrectal ultrasonography-guided biopsy of the prostate

“…2,18 We have previously evaluated the efficacy and safety of a combination of diltiazem gel along with lignocaine gel for prostate biopsy, and have compared it with nitroglycerin gel: diltiazem gel reduced the pain of prostatic biopsy and was safe compared with nitroglycerin. 19 Owing to its safety profile and clinical efficacy, we used diltiazem in the present study along with PPNB, which is presently the recommended form of analgesia for prostate biopsy. To our knowledge, this study is the only one in the literature that evaluates the efficacy of a combination of diltiazem and PPNB in reducing the pain of prostatic biopsy.…”