comparison of CT urography and excretory urography in the detection and localization of urothelial carcinoma of the upper urinary tract

Abstract

Objective: The purpose of this study was to compare the accuracy of CT urography and excretory urography for the detection and localization of upper urinary tract urothelial carcinoma. Materials and Methods: Of 128 patients at high risk for upper tract urothelial carcinoma who were examined with both CT urography and excretory urography between 2002 and 2007, 24 were undiagnosed and excluded. CT urography and excretory urography results of the remaining 104 patients and 552 urinary tract segments were compared with histopathologic examination or follow-up imaging at 1 year. Two readers independently scored the confidence levels for the presence or absence of upper urinary tract urothelial carcinoma in each of six upper urinary tract segments on both CT urography and excretory urography; differences were resolved by consensus. Results: Upper urinary tract urothelial carcinoma was diagnosed in 77 (14%) segments of 46 (44%) patients. Per-patient sensitivity, specificity, overall accuracy, and area under the receiver operating characteristic curves for detecting carcinomas with CT urography (93.5% [43/46], 94.8% [55/58], 94.2% [98/104], and 0.963, respectively) were significantly greater than those for excretory urography (80.4% [37/46], 81.0% [47/58], 80.8% [84/104], and 0.831, respectively) (p = 0.041, p = 0.027, p = 0.001, and p < 0.001, respectively). Persegment sensitivity and overall accuracy for the localization of upper urinary tract urothelial carcinoma were significantly greater with CT urography (87.0% [67/77] and 97.8% [540/552]) than with excretory urography (41.6% [32/77] and 91.5% [505/552]) (p < 0.0001). Conclusion: CT urography was more accurate than excretory urography in the detection and localization of upper urinary tract urothelial carcinoma and should be considered as the initial examination for the evaluation of patients at high risk for upper urinary tract urothelial carcinoma.

Upper Urinary Tract Tumors: Which Diagnostic Methods Are Needed?

“…CT urography can combine the advantages of both CT scanning and IVU [22,23] . In a direct comparison of CT urography and excretory urography in a cohort of more than 100 patients, a significantly greater accuracy of CT urography was reported (sensitivity 93%, specificity 94%) [24] . Even if a CT is performed immediately after a conventional IVU with delayed excretion, a correct diagnosis has been reported in 97% of cases [25] .…”

Comparison of CT Urography and MRI in Bladder Cancer Detection

“…urethral cancers 8,9 , and in detecting bladder cancer [10][11][12] . A patient presenting with macroscopic hematuria is recommended to undergo CTU in combination with cystoscopy and ultrasonography, with a differential diagnosis including urothelial cancer 4,13 .…”

Detection of bladder cancer: comparison of low-dose scans with AIDR 3D and routine-dose scans with FBP on the excretory phase in CT urography

“…However, CTU is an excellent technique for the evaluation of calculi and masses in the urinary system performed using the helical scan. [1][2][3] The contrast resolution of CTU is superior to that of conventional excretory urography and has become one of the robust imaging tools for the evaluation of the urinary system. 2 However, CTU results in higher radiation exposure than conventional excretory urography.…”

“…[1][2][3] The contrast resolution of CTU is superior to that of conventional excretory urography and has become one of the robust imaging tools for the evaluation of the urinary system. 2 However, CTU results in higher radiation exposure than conventional excretory urography. [1][2][3][4] Therefore, the reduction of radiation dose on CTU is an important problem to be resolved.…”

“…2 However, CTU results in higher radiation exposure than conventional excretory urography. [1][2][3][4] Therefore, the reduction of radiation dose on CTU is an important problem to be resolved.…”