Efficacy of three different alpha 1-adrenergic blockers and hyoscine N-butylbromide for distal ureteral stones

Abstract

Purpose: To evaluate hyoscine N-butyl bromide (HBB) and three different alpha-1 blockers in the treatment of distal ureteral stones. Materials and Methods: A total of 140 patients with stones located in the distal tract of the ureter with stone diameters of 5 to 10mm were enrolled in the present study and were randomized into 4 equal groups. Group 1 received HBB, Group 2 received alfuzosin, Group 3 received doxazosin and Group 4 received terazosin. The subjects were prescribed diclofenac injection (75 mg) intramuscularly on demand for pain relief and were followed-up after two weeks with x-rays of the kidneys, ureters, bladder and urinary ultrasonography every week. The number of pain episodes, analgesic dosage and the number of days of spontaneous passage of the calculi through the ureter were also recorded. Results: The average stone size for groups 1, 2, 3 and 4 was comparable (6.13, 5.83, 5.59 and 5.48 mm respectively). Stone expulsion was observed in 11%, 52.9%, 62%, and 46% in groups 1, 2, 3 and 4 respectively. The average time to expulsion was 10.55 ± 6.21 days in group 1, 7.38 ± 5.55 days in group 2, 7.85 ± 5.11 days in group 3 and 7.45 ± 5.32 days in group 4. Alpha blockers were found to be superior to HBB (p < 0.05). Conclusions: Medical treatment of distal ureteral calculi with alfuzosin, doxazosin and terazosin resulted in a significantly increased stone-expulsion rate and decreased expulsion time when compared with HBB. HBB seems to have a negative effect on stone-expulsion rate.

Linear pharmacokinetics of doxazosin in healthy subjects

“…Doxazocin can be also indicated in the treatment of distal ureteral calculi since recent studies indicated that doxazosin administration caused a significant increase in stone expulsion rate and a decrease in expulsion time (Gurbuz et al, 2011). Moreover, recent investigation recommended the use of doxazosin for children to get rid of stone within a shorter period and consequently diminish the frequency of colic attacks and the need for using analgesics (Erturhan et al, 2013).…”

Üriner Sistem Taş Hastalığı ve Ağrı Tedavisi: Yeni Ne Var?

“…Ketorolak ile birlikte hiyosin n-butilbromür verilmesinin birinci saatte tek başına ketorolak verilmesine göre ağrıyı daha belirgin olarak azalttığı görülmüştür (27). Ancak n-butil bromidin taşın düşme süresini uzattığına dair veriler kullanı-mını kısıtlamaktadır (28).…”

Tamsulosin: Ureteral Stones (Distal)

“…[2][3][4] Tamsulosin is a selective alpha-1 receptor antagonist; the action of alpha blockers on ureteral smooth muscle dilatates the lumen and inhibits spasms, especially in the distal part of the ureter. 5 …”