The implication of initial 24-core transrectal prostate biopsy protocol on the detection of significant prostate cancer and high grade prostatic intraepithelial neoplasia

Nomikos, Michael; Karyotis, I.; Phillipou, Prodromos; Constadinides, Charalambos; Delakas, Dimitrios

doi:10.1590/s1677-55382011000100011

Cited by 8 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The higher the PSA level, the greater the PCa positivity rate (especially when >10 ng/mL), which was also evidenced in other studies [15,18]. In two patients with a PSA level <2.0 ng/mL, PCa was detected on biopsy.…”

Section: Discussionsupporting

confidence: 75%

“…The correlation between Gleason scores and the biopsy protocol and PSA values in other studies also showed no significant differences in tumor detection rates [15,22]. Mian et al [23] studied 426 patients, 221 of whom had undergone sextant biopsy and 205 saturation biopsy before radical prostatectomy.…”

Section: Discussionmentioning

confidence: 97%

“…However, on second and third rebiopsies, the saturation biopsy had a higher detection rate than did the 18-core biopsy: 22% versus 10.9% (p=0.003) and 6.2% versus 0%, respectively. Nomikos et al [15], in a retrospective study, compared 24-core and 10-core protocols; PCa detection rates were 34.55% and 39.09%, respectively (p=0.43). However, the study by Ceylan et al [16] showed a benefit of saturation biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…The indication for biopsy was the presence of prostatic nodules detected on DRE, which indicated that this type of examination may reveal tumors in men with a low PSA level [3]. In other studies also, no statistically significant differences were found between PSA levels by the number of cores [15,16,18]. …”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?

et al. 2014

View full text Add to dashboard Cite

PurposeWe evaluated the utility of 10-, 12-, and 16-core prostate biopsies for detecting prostate cancer (PCa) and correlated the results with prostate-specific antigen (PSA) levels, prostate volumes, Gleason scores, and detection rates of high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP).Materials and MethodsA prospective controlled study was conducted in 354 consecutive patients with various indications for prostate biopsy. Sixteen-core biopsy specimens were obtained from 351 patients. The first 10-core biopsy specimens were obtained bilaterally from the base, middle third, apex, medial, and latero-lateral regions. Afterward, six additional punctures were performed bilaterally in the areas more lateral to the base, middle third, and apex regions, yielding a total of 16-core biopsy specimens. The detection rate of carcinoma in the initial 10-core specimens was compared with that in the 12- and 16-core specimens.ResultsNo significant differences in the cancer detection rate were found between the three biopsy protocols. PCa was found in 102 patients (29.06%) using the 10-core protocol, in 99 patients (28.21%) using the 12-core protocol, and in 107 patients (30.48%) using the 16-core protocol (p=0.798). The 10-, 12-, and 16-core protocols were compared with stratified PSA levels, stratified prostate volumes, Gleason scores, and detection rates of HGPIN and ASAP; no significant differences were found.ConclusionsCancer positivity with the 10-core protocol was not significantly different from that with the 12- and 16-core protocols, which indicates that the 10-core protocol is acceptable for performing a first biopsy.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Another study has shown no difference between a 6- and a 12-core approach, with detection rates of 26 and 27% [24]. A study has shown that an extreme 24-core approach did not improve PC detection compared with a 10-core approach, with PC detection rates of 39.1 and 34.6%, respectively [25]. A recent study has suggested that the number of cores does not impact PC diagnosis, but that the length of the cores should be appropriate [26].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Different Systematic Prostate Biopsy Methods in the Detection of Prostate Cancer with Ultrasonographic Hypoechoic Lesions - A Comparative Study

Yao²,

Wu³

et al. 2015

Urol Int

View full text Add to dashboard Cite

Objective: To assess if a less extended biopsy in the transperineal approach is sufficient for detection of prostate cancer (PC) in patients with hypoechoic lesions. Methods: This was a prospective study of 167 consecutive patients with prostate hypoechoic lesion and who underwent transperineal ultrasound (TPUS)-guided 12-core and hypoechoic lesion core biopsy between January 2012 and February 2013. Results: PC was detected in 64.1% (107/167) of patients. The PC detection rate of the 12-core prostate biopsy scheme was the highest, but when including the hypoechoic lesion core, there was no difference between the 6- and 12-core schemes (all p > 0.05), irrespective of prostate volume or prostate-specific antigen levels (all p > 0.05). Conclusions: A more limited biopsy scheme could be sufficient for the detection of PC if the hypoechoic lesion is sampled.

show abstract

Fluoroquinolone-based antimicrobial prophylaxis in patients undergoing transrectal ultrasound-guided prostate biopsy

Sieczkowski

Gibas

Bronk

et al. 2015

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

The aim of this study was to establish the prevalence of resistance to fluoroquinolones in Escherichia coli strains isolated from patients undergoing transrectal ultrasound-guided prostate biopsy (TRUS-Bx) and to evaluate the incidence of possible infectious complications associated with this procedure. One hundred and four patients undergoing a TRUS-Bx in a single medical centre were prospectively enrolled in this study. In all patients, pre-biopsy rectal swabs were obtained. The analysis determined the antimicrobial susceptibility of E. coli strains to levofloxacin, ciprofloxacin and a panel of other antibiotics. Before biopsy, each of the men received a levofloxacin-based prophylaxis. Telephone follow-up was used to identify patients who had complications after TRUS-Bx. Fluoroquinolone-resistant strains were isolated from 9.62 % of the patients. In all cases, there were related to E. coli and all those strains were resistant to both levofloxacin and ciprofloxacin. Fluoroquinolones showed greater antimicrobial activity against E. coli (p < 0.05) than ampicillin, amoxicillin/clavulanate and cephalothin. Minor infectious complications occurred in three patients (2.91 %). The relation between the resistance of E. coli to fluoroquinolones and the risk of readmission, as well as infectious complications, was statistically significant (p < 0.05). Despite recent reports of increasing prevalence of fluoroquinolone-resistant E. coli and the associated increase of severe infectious complications, the presented results have not confirmed this phenomenon. Resistance to fluoroquinolones of E. coli strains isolated from rectal swab cultures prior to TRUS-Bx is the risk factor for readmission and infectious complications after this procedure.

show abstract

The implication of initial 24-core transrectal prostate biopsy protocol on the detection of significant prostate cancer and high grade prostatic intraepithelial neoplasia

Cited by 8 publications

References 22 publications

What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?

What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?

Diagnostic Value of Different Systematic Prostate Biopsy Methods in the Detection of Prostate Cancer with Ultrasonographic Hypoechoic Lesions - A Comparative Study

Fluoroquinolone-based antimicrobial prophylaxis in patients undergoing transrectal ultrasound-guided prostate biopsy

Contact Info

Product

Resources

About