Rate of renal cell carcinoma subtypes in different races

Sankin, Alexander; Cohen, Jacob; Wang, Hongbei; Macchia, Richard J.; Καρανικόλας, Νικόλαος

doi:10.1590/s1677-55382011000100004

Cited by 28 publications

(18 citation statements)

References 12 publications

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“…We found that papillary RCC was nearly threefold more common in black patients compared to white patients in our cohort. This is consistent with prior single institutional and national registry cohorts that demonstrate a similar increased frequency of papillary histology in black patients [7,23]. Various factors could account for this finding.…”

Section: Discussionsupporting

confidence: 91%

Racial disparities in renal cell carcinoma: a single‐payer healthcare experience

Mafolasire

Yao²,

Nawaf

et al. 2016

Cancer Medicine

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Significant racial disparities in survival for renal cell carcinoma (RCC) exist between white and black patients. Differences in access to care and comorbidities are possible contributors. To investigate if racial disparities persist when controlling for access to care, we analyzed data from a single-payer healthcare system. As part of a case-control study within the Kaiser Permanente Northern California system, pathologic and clinical records were obtained for RCC cases (2152 white, 293 black) diagnosed from 1998 to 2008. Patient demographics, comorbidities, tumor characteristics, and treatment status were compared. Overall survival and disease-specific survival (DSS) were calculated by the Kaplan-Meier method. A Cox proportion hazards model estimated the independent associations of race, comorbidity, and clinicopathologic variables with DSS. We found that compared to white patients, black patients were diagnosed at a younger age (median 62 vs. 66 years, P < 0.001), were more likely to have papillary RCC (15% vs. 5.2%, P < 0.001), and had similar rates of surgical treatment (78.8% vs. 77.9%, P = 0.764). On multivariate analysis, advanced American Joint Committee on Cancer (AJCC) stage, lack of surgical treatment, larger tumor size, and higher grade were predictors of worse DSS. Race was not an independent predictor of survival. Therefore, we conclude that within a single healthcare system, differences in characteristics of black and white patients with RCC persist; black patients had different comorbidities, were younger, and had decreased tumor stage. However, unlike other series, race was not an independent predictor of DSS, suggesting that survival differences in large registries may result from barriers to healthcare access and/or comorbidity rather than disease biology. Cancer Medicine Open Access 2102

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Section: Discussionsupporting

confidence: 91%

Racial disparities in renal cell carcinoma: a single‐payer healthcare experience

Mafolasire

Yao²,

Nawaf

et al. 2016

Cancer Medicine

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“…Chromophobe RCC was also observed to be the most common RCC histologic subtype in two case series of young adults 27, 28. RCC subtypes have recently been reported to differ by race; RCC cases in black patients were nearly five times more likely to be of papillary histology than RCC from nonblack patients in a U.S. multicenter case series,15 and three times more likely in an analysis within the Surveillance, Epidemiology, and End Results (SEER) Program 29. Our finding suggesting that black patients are also more likely than white patients to be diagnosed with RCC of other, rarer histologies warrants further investigation within the SEER Program.…”

Section: Discussionmentioning

confidence: 99%

“…As RCC histologic subtypes have been reported to differ in frequency by age, sex and race,11–15 it has been speculated that RCC subtypes may possess distinct etiologies 16. Of the few studies that have investigated this question, there is limited evidence suggesting that the association between obesity and RCC may be subtype‐specific.…”

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confidence: 99%

An investigation of risk factors for renal cell carcinoma by histologic subtype in two case‐control studies

Purdue

Moore

Merino

et al. 2013

Intl Journal of Cancer

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To investigate whether renal cell carcinoma (RCC) histologic subtypes possess different etiologies, we conducted analyses of established RCC risk factors by subtype (clear cell, papillary, chromophobe) in two case-control studies conducted in the United States (1,217 cases, 1,235 controls) and Europe (1,097 cases, 1,476 controls). Histology was ascertained for 706 U.S. cases (58% of total) and 917 European cases (84%) through a central slide review conducted by a single pathologist. For the remaining cases, histology was abstracted from the original diagnostic pathology report. Case-only analyses were performed to compute odds ratios (ORs) and 95% confidence intervals (CI) summarizing subtype differences by age, sex, and race. Case-control analyses were performed to compute subtype-specific ORs for other risk factors using polytomous regression. In case-only analyses, papillary cases (N=237) were older (OR=1.2, 95% CI=1.1–1.4 per 10-year increase), less likely to be female (OR=0.5, 95 % CI=0.4- 0.8) and more likely to be black (OR=2.6, 95% CI=1.8–3.9) compared to clear cell cases (N=1,524). In case-control analyses, BMI was associated with clear cell (OR=1.2, 95% CI=1.1–1.3 per 5kg/m2 increase) and chromophobe RCC (N=80; OR=1.2, 95% CI=1.1- 1.4), but not papillary RCC (OR=1.1, 95% CI=1.0–1.2; test vs. clear cell, P=0.006). No subtype differences were observed for associations with smoking, hypertension or family history of kidney cancer. Our findings support the existence of distinct age, sex and racial distributions for RCC subtypes, and suggest that the obesity-RCC association differs by histology.

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“…Data also reflects that Asian Americans have the lowest incidence of renal tumors compared to African Americans and Caucasians (Siegal, 2012). A study in Brazil concluded that papillary RCC had much higher occurrence among black patients compared to non-blacks (Sankin et al, 2011).…”

Section: Clinicopathologic Patterns Of Adult Renal Tumors In Pakistanmentioning

confidence: 99%

Clinicopathologic Patterns of Adult Renal Tumors in Pakistan

Hashmi

Ali²,

Hussain³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Renal cancer is a serious public health problem which may be under reported and registered in our setup, since the Karachi cancer registry documented only 43 cases out of 4,268 incident cancer cases over 3 year duration. Therefore we aimed to determine the clinicopathologic characteristics of adult renal tumors in our setup. Materials and Methods: The study was conducted in histopathology department, Liaquat National Hospital and included total of 68 cases of adult renal tumors over 4 years. Detailed histopathologic characteristics of tumors were analyzed. Results: Mean age of patients was 56.4 (18-84) years. Renal cell carcinoma (RCC) was the most common cell type (78%) cases; followed by transitional/urothelial carcinoma (12.5%), leiomyosarcoma (4.7%), oncocytoma (1.6%), squamous cell carcinoma (1.6%) and high grade pleomorphic undifferentiated sarcoma (1.6%). Among 50 RCC cases; 62% were conventional/clear cell RCC (CCRCC) type followed by papillary RCC(PRCC), 24%; chromophobe RCC(CRCC), 6% and sarcomatoid RCC(SRCC), 8%. Mean tumor size for RCC was 7.2 cm. Most RCCs were intermediate to high grade (60% and 40% respectively). Capsular invasion, renal sinus invasion, adrenal gland involvement and renal vein invasion was seen in 40%, 18%, 2% and 10% of cases respectively. Conclusions: We found that RCC presents at an earlier age in our setup compared to Western populations. Tumor size was significantly larger and most of the tumors were of intermediate to high grade. This reflects late presentation of patients after disease progression which necessitates effective measures to be taken in primary care setup to diagnose this disease at an early stage.

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Rate of renal cell carcinoma subtypes in different races

Abstract: In our study, papillary RCC had a much higher occurrence among black patients compared to non-black patients. This is the first study to document such a great racial disparity among RCC subtypes.

Cited by 28 publications

References 12 publications

Racial disparities in renal cell carcinoma: a single‐payer healthcare experience

Racial disparities in renal cell carcinoma: a single‐payer healthcare experience

An investigation of risk factors for renal cell carcinoma by histologic subtype in two case‐control studies

Clinicopathologic Patterns of Adult Renal Tumors in Pakistan

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