Reconstructive Urology

Abstract

GH + E(2). The treatment groups received daily subcutaneous injections for 3 weeks. The effects of hormone Results: The sham rats had a mean (sd) voiding frequency of 3 (0.87) times in 10 min and a bladder capacity of 0.43 (0.13) mL with smooth cystometry curves. The number of rats in each treatment group (each group contained nine rats) that had voiding dysfunction was as follows: E(2), three; raloxifene, six; levormeloxifene, four; and controls, four (P > 0.05 among the groups). Only one rat in the GH-treated group and no rats in the than in the controls (P = 0.041). Conclusion: This functional data suggest that the development of voiding dysfunction can be prevented by short-term administration of GH and GH + E(2) in our rat model. SERMs and E(2) alone seem to have no therapeutic effect. Editorial CommentThis is a wished study by Dr. Lue and collaborators that have been working on this topic for the last years. They analyzed if short-term therapy with ultra-low dose of estrogen, selective estrogen receptor modulators (SERMs), and growth hormone (GH) can prevent the development of voiding dysfunction in a postpartum, postmenopausal voiding dysfunction rat model. By using conscious cistometry, developed in its own laboratory, the authors found that short-term therapy with E2, SERMs and GH suggest that, in the dosage and duration used, GH and GH + E2 seem to prevent the development of voiding dysfunction while E2 alone hormones on voiding, with the consequent clinical implications for treating and preventing post-partum and postmenopausal voiding dysfunction. Dr. Francisco J. B. Sampaio Full-Professor and Chair, Urogenital Research UnitState University of Rio de Janeiro Rio de Janeiro, RJ, Brazil E-mail: sampaio@urogenitalresearch.org RECONSTRUCTIVE UROLOGY __________________________________________________A collagen matrix derived from bladder can be used to engineer smooth muscle tissue Kim BS, Atala A, Yoo JJ Department of Bioengineering, Hanyang University, Seoul, South KoreaWe have previously demonstrated that a collagen matrix derived from lamina propria, commonly known as bladder submucosa (BSM matrix), is a suitable biomaterial for several urologic applications, including reconstruction of the bladder and urethra in experimental models and clinical trials. In the present study, we evaluated the physical properties of BSM as well as its biocompatibility, cellular interactions, and ability to support the formation of functional tissue in order to determine whether this biomaterial could serve as a matrix for urinary smooth muscle tissue engineering. BSM matrix resembles the extracellular matrix of bladder submucosa in its native structure, composition, and mechanical properties. BSM matrix supported normal