Investigative Urology

Abstract

progression varies from 36% to 72% in the literature (1). In our Institution, the progression in 300 patients was 37% after 5 years of follow-up.cal margins (2): b) Iatrogenic surgical margin occurs whenever there is a transection of the intraprostatic tumor. If this occurs, one cannot determine whether there is extraprostatic extension in the region of incision into the prostate as the edge of the prostate has been left in the patient. Unless there is extraprostatic extension in other areas of the surgical specimen, the pathologic stage is called pT2+; c) Non-iatrogenic surgical positive margin occurs whenever there is an inability to widely excise tumor showing extraprostatic extension.It is worth mentioning the possibility of positive surgical margins in normal prostatic glands. This is not routinely reported by the pathologist; however, it is very important to report in cases of limited carcinoma in the surgical specimen. In these cases, biochemical (PSA) progression following surgery may be due to normal glands left in the patient. In our Institution, no patient with limited carcinoma in the specimen had biochemical progression, except 3 patients. Reviewing the prostatectomy slides, we found that all 3 patients had frequent and extensive positive surgical margins in normal glands. Dr. Athanase Billis Full-Professor of Pathology State University of Campinas, UnicampCampinas, São Paulo, Brazil E-mail: athanase@fcm.unicamp.br INVESTIGATIVE UROLOGY _____________________________________________________ Protein oxidation as a novel biomarker of bladder decompensationKalorin CM, Mannikarottu A, Neumann P, Leggett R, Weisbrot J, Johnson A, Kogan BA, Levin RM Albany Medical College, Albany, NY, USA BJU Int. 2008; 102: 495-9 Objective: To measure the degree to which partial bladder outlet obstruction (PBOO) results in oxidative bladder damage, which subcellular components of the bladder are affected and whether these changes correlate with bladder function. Materials and Methods: In all, 32 rabbits were divided into four groups. Each group underwent PBOO for 1, 2, 4, and 8 weeks, respectively. Bladder tissue from each group was homogenized and separated into subcellular 1.2.