Inverse correlation between testosterone and ventricle ejection fraction, hemodynamics and exercise capacity in heart failure patients with erectile dysfunction

Bocchi, Edimar Alcides; Carvalho, Vitor Oliveira; Guimarães, Guilherme Veiga

doi:10.1590/s1677-55382008000300007

Cited by 28 publications

(19 citation statements)

References 27 publications

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“…It is characterized by a persistent overactivity of the neurohormonal system [3], endothelial dysfunction [4], exercise intolerance [5,6], high mortality [7], and a poor quality of life [8].…”

Section: Introductionmentioning

confidence: 99%

Pilates in Heart Failure Patients: A Randomized Controlled Pilot Trial

Guimarães

Carvalho

Bocchi

et al. 2011

Cardiovascular Therapeutics

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Background: Conventional cardiac rehabilitation program consist of 15 min of warmup, 30 min of aerobic exercise and followed by 15 min calisthenics exercise. The Pilates method has been increasingly applied for its therapeutic benefits, however little scientific evidence supports or rebukes its use as a treatment in patients with heart failure (HF). Purpose: Investigate the effects of Pilates on exercise capacity variables in HF. Methods: Sixteen pts with HF, left ventricular ejection fraction 27 ± 14%, NYHA class I-II were randomly assigned to conventional cardiac rehabilitation program (n = 8) or mat Pilates training (n = 8) for 16 weeks of 30 min of aerobic exercise followed by 20 min of the specific program. Results: At 16 weeks, pts in the mat Pilates group and conventional group showed significantly increase on exercise time 11.9 ± 2.5 to 17.8 ± 4 and 11.7 ± 3.9 to 14.2 ± 4 min, respectively. However, only the Pilates group increased significantly the ventilation (from 56 ± 20 to 69 ± 17 L/min, P = 0.02), peak VO 2 (from 20.9 ± 6 to 24.8 ± 6 mL/kg/min, P = 0.01), and O 2 pulse (from 11.9 ± 2 to 13.8 ± 3 mL/bpm, P = 0.003). The Pilates group showed significantly increase in peak VO 2 when compared with conventional group (24.8 ± 6 vs. 18.3 ± 4, P = 0.02). Conclusions: The result suggests that the Pilates method may be a beneficial adjunctive treatment that enhances functional capacity in patients with HF who are already receiving standard medical therapy. BackgroundHeart failure (HF) is considered to be the last stage of heart diseases and a worldwide cause of mortality and morbidity [1,2]. It is characterized by a persistent overactivity of the neurohormonal system [3], endothelial dysfunction [4], exercise intolerance [5,6], high mortality [7], and a poor quality of life [8].Exercise training has been recommended as an important tool in HF treatment. It improves exercise capacity [9], quality of life [10], besides reducing endothelial dysfunction [11], catecholamine levels [12], and morbity [13].Pilates is a particular exercise approach that was founded on the teachings of Joseph Pilates (1880Pilates ( -1967 and was initially practiced almost exclusively by athletes and dancers. Pilates has become a fast-growing, popular trend in rehabilitation and fitness programs in recent years. The goal of Pilates training is improvement of general body flexibility and health, emphasizing core (truncal) strength, posture, and coordination of breathing with movement. Anecdotal evidence suggests that as the Pilates method increases core strength, the natural flexibility of the spine and limbs returns [14,15,16].Despite this promising method, there is little scientific research on the effectiveness of Pilates. The purpose of this study was to investigate the effects of Pilates on exercise capacity variables in HF patients. Methods Study PopulationA total of 26 outpatients with HF were recruited from a tertiary cardiology hospital with the following criteria: clinical and optimized farmacological treatment (for at least 3...

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Section: Introductionmentioning

confidence: 99%

Pilates in Heart Failure Patients: A Randomized Controlled Pilot Trial

Guimarães

Carvalho

Bocchi

et al. 2011

Cardiovascular Therapeutics

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show abstract

“…Heart failure is considered the last stage of heart disease and a significant cause of worldwide mortality and morbidity 1,2,3. The end-stage of heart failure, which is marked by a lack of response to medical treatment, disabling symptoms, and repeated hospital stays, is associated with high morbidity and mortality 4.…”

Section: Introductionmentioning

confidence: 99%

Norepinephrine Remains Increased in the Six-Minute Walking Test after Heart Transplantation

Guimarães

Ávila

Bocchi

et al. 2010

Clinics

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OBJECTIVE:We sought to evaluate the neurohormonal activity in heart transplant recipients and compare it with that in heart failure patients and healthy subjects during rest and just after a 6-minute walking test.INTRODUCTION:Despite the improvements in quality of life and survival provided by heart transplantation, the neurohormonal profile is poorly described.METHODS:Twenty heart transplantation (18 men, 49±11 years and 8.5±3.3 years after transplantation), 11 heart failure (8 men, 43±10 years), and 7 healthy subjects (5 men 39±8 years) were included in this study. Blood samples were collected immediately before and during the last minute of the exercise.RESULTS:During rest, patients’ norepinephrine plasma level (659±225 pg/mL) was higher in heart transplant recipients (463±167 pg/mL) and heathy subjects (512±132), p<0.05. Heart transplant recipient’s norepinephrine plasma level was not different than that of healthy subjects. Just after the 6-minute walking test, the heart transplant recipient’s norepinephrine plasma level (1248±692 pg/mL) was not different from that of heart failure patients (1174±653 pg/mL). Both these groups had a higher level than healthy subjects had (545±95 pg/mL), p<0.05.CONCLUSION:Neurohormonal activity remains increased after the 6-minute walking test after heart transplantation.

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“…Heart failure is considered to be the final stage of heart disease and a significant cause of worldwide mortality and morbidity [1][2][3][4]. End-stage of heart failure, which is marked by a lack of response to medical treatment, disabling symptoms and repeated hospital stays, is associated with high morbidity and mortality [5].…”

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confidence: 99%