The use of enoxaparin to prevent venous thromboembolism in patients undergoing radical retropubic prostatectomy: feasibility and utility

Nakamura, Kogenta; Yacoub, Saif; Pendleton, John; Anai, Satoshi; Rosser, Charles J.

doi:10.1590/s1677-55382007000300007

Cited by 4 publications

(4 citation statements)

References 20 publications

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Section: Antithrombotic Prophylaxis In Surgical Urological Cancer Patientsmentioning

confidence: 99%

“…Available studies also refer to postoperative antithrombotic prophylaxis as one of the VTE prevention methods [184,185]. Nakamura et al used enoxaparin at the dose of 40 mg (prophylaxis began 6-8 hours after surgery) in a group of 47 patients who underwent open prostatectomy and reported VTE incidence at 4% [184]. Grasso et al [185] retrospectively analyzed 500 patients after radical prostatectomy who received hemodilution, compression stockings, and pharmacological prevention administered up to 24 hours after surgery and found only two VTE episodes as well as two bleeding events that required surgical intervention.…”

Section: Antithrombotic Prophylaxis In Surgical Urological Cancer Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Wytyczne leczenia i profilaktyki żylnej choroby zatorowo-zakrzepowej u chorych onkologicznych leczonych operacyjnie z uwzględnieniem chorych poniżej 18. roku życia

Krasiński¹,

Urbanek²,

Undas³

et al. 2021

Acta Angiologica

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Section: Antithrombotic Prophylaxis In Surgical Urological Cancer Patientsmentioning

confidence: 99%

Section: Antithrombotic Prophylaxis In Surgical Urological Cancer Patientsmentioning

confidence: 99%

Wytyczne leczenia i profilaktyki żylnej choroby zatorowo-zakrzepowej u chorych onkologicznych leczonych operacyjnie z uwzględnieniem chorych poniżej 18. roku życia

Krasiński¹,

Urbanek²,

Undas³

et al. 2021

Acta Angiologica

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show abstract

“…Available studies also refer to postoperative antithrombotic prophylaxis as one of the VTE prevention methods [239,240]. Nakumara used enoxaparin at the dose of 40 mg (prophylaxis began 6-8 hours after surgery) in a group of 47 patients, who underwent open prostatectomy, and reported VTE incidence at 4% [239].…”

Section: Venous Thromboembolism Prophylaxis In Cancer Patientsmentioning

confidence: 99%

“…Nakumara used enoxaparin at the dose of 40 mg (prophylaxis began 6-8 hours after surgery) in a group of 47 patients, who underwent open prostatectomy, and reported VTE incidence at 4% [239]. Grasso et al retrospectively analyzed 500 patients after radical prostatectomy, who received hemodilution, compression stockings, and pharmacological prevention administered up to 24 hours after surgery and found only two VTE episodes as well as two bleeding complications that required surgical intervention [240].…”

Section: Venous Thromboembolism Prophylaxis In Cancer Patientsmentioning

confidence: 99%

Venous thromboembolism prophylaxis in cancer patients — guidelines focus on surgical patients

Urbanek¹,

Krasiński

Kostrubiec

et al. 2017

Acta Angiologica

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Venous Thromboembolism (VTE) in Post-Prostatectomy Patients: Systematic Review and Meta-Analysis

Wani

Al-Mitwalli

Mukherjee

et al. 2023

JCM

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Radical prostatectomy (RP) is one of the recommended treatments to achieve oncological outcomes in localized prostate cancer. However, a radical prostatectomy is a major abdominopelvic surgery. Venous thromboembolism (VTE) is a well-known complication associated with surgical procedures, including RP. There is a lack of consensus regarding VTE prophylaxis in urological procedures. The aim of this systematic review and meta-analysis was to investigate different aspects of VTE in post-radical prostatectomy patients. A comprehensive literature search was performed, and relevant data were extracted. The primary aim was to perform a systematic review and meta-analysis (wherever possible) of VTE occurrence in post-RP patients in relation to surgical approach, pelvic lymph node dissection, and type of prophylaxis (mechanical or combined prophylaxis). The secondary aim was to investigate the incidence and other risk factors of VTE in post-RP patients. A total of 16 studies were included for quantitative analysis. Statistical methods for analysis included the DerSimonian–Laird random effects. We were able to conclude that the overall incidence of VTE in post-radical prostatectomy is 1% (95% CI) and minimally invasive procedures (MIS), including laparoscopic, as well as robotic procedures for radical prostatectomy and RP without pelvic lymph node dissection (PLND), are associated with less risk of developing VTE. Additional pharmacological prophylaxis to mechanical methods may not be necessary in all cases and should be considered in high-risk patients only.

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The use of enoxaparin to prevent venous thromboembolism in patients undergoing radical retropubic prostatectomy: feasibility and utility

Abstract: In men non-compliant with PCS, initiation of enoxaparin in the immediate postoperative setting was well-tolerated and maintained a low (4%) rate of VTE. Thus, enoxaparin may be useful in adjunct with PCS in these patients.

Cited by 4 publications

References 20 publications

Wytyczne leczenia i profilaktyki żylnej choroby zatorowo-zakrzepowej u chorych onkologicznych leczonych operacyjnie z uwzględnieniem chorych poniżej 18. roku życia

Wytyczne leczenia i profilaktyki żylnej choroby zatorowo-zakrzepowej u chorych onkologicznych leczonych operacyjnie z uwzględnieniem chorych poniżej 18. roku życia

Venous thromboembolism prophylaxis in cancer patients — guidelines focus on surgical patients

Venous Thromboembolism (VTE) in Post-Prostatectomy Patients: Systematic Review and Meta-Analysis

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