Re: Urogenital involvement in the Klippel-Trenaunay-Weber Syndrome. Treatment options and results

Vicentini, Fábio Carvalho

doi:10.1590/s1677-55382007000200019

Int. braz j urol.

2007

DOI: 10.1590/s1677-55382007000200019

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Re: Urogenital involvement in the Klippel-Trenaunay-Weber Syndrome. Treatment options and results

Fábio Carvalho Vicentini

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Blei¹

2007

Lymphatic Research and Biology

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135 FEATURED ARTICLE Kobayashi, S., T. Kishimoto, et al. (2007). Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Cancer Sci 98(5): 726-33. AbstractTumor lymphangiogenesis is now known to play a causal role in lymph node metastasis, and thus its inhibition would have great significance for the prevention of lymph node metastasis in cancer therapy. VEGF-C has recently been identified as a key molecule involved in tumor lymphangiogenesis and lymphatic metastasis. However, the expressional regulation of VEGF-C is not fully understood. We investigated the role of mTOR, which is a downstream kinase of the phosphatidylinositol 3-kinase/Akt pathway, and the MAPK family (MEK1/2, p38, and JNK) in the regulation of VEGF-C and VEGF-A expression in B13LM cells, a lymphatic metastasis-prone pancreatic tumor cell line. We also investigated the antilymphangiogenic effect of rapamycin, a specific inhibitor of mTOR in vivo using male BALB/c nu/nu mice. VEGF-C expression was inhibited by the inhibitors for mTOR, p38, and JNK, but not by the inhibitor for MEK1/2, whereas VEGF-A expression was inhibited by all four of these inhibitors. The serum starvation-induced expression of VEGF-C was inhibited by rapamycin, whereas that of VEGF-A was incompletely inhibited. The metastatic experiment in vivo demonstrated that the number and the area of lymphatic vessels in the primary tumors were significantly decreased by rapamycin. Finally, the lymph node metastasis was significantly suppressed in rapamycin- LITERATURE WATCH136 LITERATURE WATCH 137

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Blei¹

2007

Lymphatic Research and Biology

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Klippel-Trenaunay Syndrome Associated With Urinary Tract Hemangiomas: A Case Report

Ramdani,

El Moudane,

Tahri

et al. 2023

Cureus

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The association between Klippel-Trenauney syndrome (KTS) and bladder hemangiomas is rare. The most common clinical manifestation is hematuria. The diagnosis is made from the characteristic cystoscopic appearance of the tumor. We report the case of a patient presenting recurrent macroscopic hematuria in the context of KTS. A cystoscopic evaluation revealed bladder hemangiomas. A conservative approach consisting of bladder irrigation and close follow-up was chosen as therapy. Conservative treatment of bladder irrigation and close follow-up is the recommended initial treatment of moderate and infrequent episodes of hematuria in this context. The more invasive therapeutic options have to be considered especially for frequent or life-threatening episodes of hematuria. This case suggests that conservative treatment may be effective in treating moderate and infrequent episodes of hematuria due to bladder hemangioma in the context of KTS. Further studies are required to adequately establish the effectiveness, limitations, and complications of each approach.

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Re: Urogenital involvement in the Klippel-Trenaunay-Weber Syndrome. Treatment options and results

Cited by 2 publications

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Klippel-Trenaunay Syndrome Associated With Urinary Tract Hemangiomas: A Case Report

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