Incidental prostatic adenocarcinoma in patients with PSA less than 4 ng/ml undergoing radical cystoprostatectomy for bladder cancer in iranian men

Hosseini, Seyed Yousef; Danesh, Arnavaz; Parvin, Mahmoud; Basiri, Abbas; Javadzadeh, T; Safarinejad, Mohammad Reza; Nahabedian, A

doi:10.1590/s1677-55382007000200006

Cited by 24 publications

(18 citation statements)

References 33 publications

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“…Of these npg patients, three had carcinoma in situ (CIS) involving the pro s tatic urethra and six had TCC involving the prostate glands/parenchyma. Our literature review identified eight articles from Korea, Japan, Iran, India, Taiwan, China and mainland China that we believe could represent the whole Asian population [7][8][9][10][11][12][13][14]. We combined our data with the data from the reviewed literature for analysis.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy: data from China and other Asian countries

Zhu¹,

Ye²,

Yao³

et al. 2008

Asian J Androl

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The purpose of this study is to investigate the frequency of prostate cancer (Pca) discovered incidentally in radical cystoprostatectomy specimens in Asia and to determine the feasibility of prostate-sparing cystectomy (PSC) for Asian patients. Ninety-two male bladder cancer patients who underwent radical cystoprostatectomy at our center between January 2003 and January 2008 were included in this study. The mean age of patients was 67.1 years (range: 32-75 years). Prostate-specific antigen (PSA) levels and digital rectal examination (DRE) results before surgery were obtained retrospectively. Prostates of all patients were embedded and sectioned at 5-mm intervals. The same pathologist examined the prostatic tissues from radical cystoprostatectomy specimens. Finally, a structured literature review was performed using MEDLINE and PUBMED to estimate the occurrence of incidental Pca in Asia. Of the 92 patients, 3 (3.3%) were found to have Pca; in one out of three (33.3%) patients the disease was clinically significant due to a Gleason grade 4 carcinoma. Eight articles were included in our review. The overall incidence of Pca discovered incidentally in radical cystoprostatectomy specimens in Asia was 9.9% (64/642). When age was restricted to < 60 years, only 7 out of 222 (3.2%) patients were found to have synchronous Pca, and none of the cases was clinically significant. The occurrence of Pca in radical cystoprostatectomy specimens in Asia is much lower than that in Western countries. PSC might be feasible for Asian patients under a strict preoperative selection.

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Section: Resultsmentioning

confidence: 99%

Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy: data from China and other Asian countries

Zhu¹,

Ye²,

Yao³

et al. 2008

Asian J Androl

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“…Four percent to 57% of prostate specimens included in studies with partial processing harboured clinically significant cancer [23,24]. In our study, 21 out of 56 (37.5%) incidental prostate cancers had a Gleason score of 7 or more and/or a stage of pT3a or more and/or invasion of the surgical margin.…”

Section: Discussionmentioning

confidence: 51%

“…To date, the reported rates of incidental prostate cancer in cystoprostatectomised patients have been in the range of 14-45% in studies with partial sampling and 3-72% in those with complete sampling [23,24,25,26]. Recent evidence shows that complete prostate processing results in a substantially higher rate of finding the carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Influence of gross specimen sampling on the incidence of incidental prostatic carcinoma in cystoprostatectomy specimens of patients with bladder carcinoma

Mlakar

Volavšek²

2016

pjp

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Reported prostate cancer incidence rates vary greatly among cystoprostatectomy samples. We investigated how the thoroughness of prostate sampling influences prostatic carcinoma incidence in bladder cancer patients. In a retrospective study, 313 cystoprostatectomy cases of urinary bladder carcinoma were analysed for the presence of concurrent prostatic carcinoma. Patients were divided into two groups: patients who had undergone the operation before and after 2007, when a policy of preferably complete prostate sampling in cystoprostatectomy specimens was introduced at our institution. Cases processed after the 2007 recommended sampling changes had a significantly higher rate of incidental prostatic carcinoma and clinically significant prostatic carcinoma than the pre-2007 group (p < 0.0001 and p = 0.003, respectively). Complete prostate processing in cystoprostatectomy specimens results in a higher incidence of incidental prostatic carcinoma than with partial processing. More patients with clinically significant prostate cancer are consequently discovered. In conclusion, we believe that complete prostate sampling should be mandatory.

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“…Incidental prostate carcinoma rates detected in cases having undergone RCP due to bladder tumor vary between 4% and 60% (Table 2) (2,6,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). One of the reasons for these various rates has been linked to the use of section intervals in different widths.…”

Section: Discussionmentioning

confidence: 99%

Incidental Prostate Cancer Frequency and Features of Patients Undergoing Radical Cystoprostatectomy

Balci¹,

Onuk²,

Hazar³

et al. 2016

JAREM

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Objective: Prostate cancer (PC) is one of the major health problems among males. Pathology specimens of patients with incidental PC who underwent radical cystoprostatectomy (RCP) have been reported to be 17-70% in different series. In this study, we aimed to determine the frequencies and features of incidental PC in patients who underwent RCP.Methods: In our study, 142 patients who underwent RCP were retrospectively evaluated between 1999 and 2015. Women and patients diagnosed with PC before were excluded. Preoperative PSA levels were 2.05-9.31 ng/mL. Standard RSP and standard pelvic lymphadenectomy were performed.Results: Incidental PC was detected in 22 of 142 patients. The frequency of incidental PC was found to be 15.4% in RSP materials. In 10 of 22 patients with PC, high-grade prostatic intraepithelial neoplasia (PIN) areas were detected. Further, 14 of 120 patients without PC had highgrade PIN zones. In 140 patients, transitional cell carcinoma was detected, and the other 2 patients had signet ring cell carcinoma. In bladder specimens, 68 patients were in the T2 stage, while 58 patients and 16 patients were in the T3 and T4 stages, respectively. The Gleason score (GS) was 2+3=5 in 2 of the 22 incidental PC patients. Moreover, 6 patients had GS of 3+2=5 and 14 patients had GS of 3+3=6. Conclusion:Most incidentally detected PCs in RCP specimens are small, localized, and well-differentiated tumors. Extracapsular extension was not observed in any of them. Patients with invasive bladder tumors and PCs together have a lower T stage than those with only invasive bladder tumors. The risk of PC is higher in patients with invasive bladder cancer than in the healthy population. Preoperative prostate evaluation, prostate dissection, and resection should be performed with oncologic surgery. (JAREM 2016; 6: 15-8)

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Incidental prostatic adenocarcinoma in patients with PSA less than 4 ng/ml undergoing radical cystoprostatectomy for bladder cancer in iranian men

Abstract: We conclude that incidentally detected prostate cancer in Iran is lower than the rates reported in other countries. Further studies are warranted for better declaration of variability of prostate cancer between different ethnic groups.

Cited by 24 publications

References 33 publications

Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy: data from China and other Asian countries

Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy: data from China and other Asian countries

Influence of gross specimen sampling on the incidence of incidental prostatic carcinoma in cystoprostatectomy specimens of patients with bladder carcinoma

Incidental Prostate Cancer Frequency and Features of Patients Undergoing Radical Cystoprostatectomy

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