Carcinoma of the renal pelvis and ureter

Korkes, Fernando; Silveira, Thiago S; Castro, Marí­lia Germanos de; Cuck, Gustavo; Fernandes, Roni C.; Perez, Marcelo Vaz

doi:10.1590/s1677-55382006000600005

Cited by 19 publications

(14 citation statements)

References 24 publications

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“…Urothelial carcinoma (UC) of the ureter and renal pelvis is relatively uncommon, accounting for only 5-6% of all urothelial tumours [1,2]. Two groups have assessed the trends in incidence of upper urinary tract (UUT) tumours.…”

Section: Introductionmentioning

confidence: 99%

“…Data on distribution of stage and grade at initial presentation indicate that most patients present with a low stage (Ta-T1) grade 2 or 3 tumour [1,[6][7][8][9]. Stage and grade are the most important prognostic factors for recurrence and survival [7][8][9][10][11], but type of treatment [7] and multifocality [8,12], have also been reported to be important, to a variable extent.…”

Section: Introductionmentioning

confidence: 99%

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Trends in epidemiology and treatment of upper urinary tract tumours in the Netherlands 1995–2005: an analysis of PALGA, the Dutch national histopathology registry

et al. 2010

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the next year, of cancer of the renal pelvis or ureter during the period 1995-2005, were included. The number of surgically treated UUT tumours per year, type of treatment and tumour characteristics were recorded. RESULTSThe population consisted of 2321 (67%) men and 1145 (33%) women with a mean age of 68.6 years. The distribution according to side was similar (left 44.1%, right 41.5%), bilateral tumours were rare (0.6%) and most tumours were in the renal pelvis (51.3%). Both the incidence and the incidence rate per 100 000 person-years increased during the study period ( P < 0.001). Most urothelial cancers were grade 2 (40.9%) or 3 (41.2%) and stage Ta (30.6%), T1 (18.1%) or T3 (22.8%). There was an increase in grade 3 ( P = 0.003) and muscle-invasive ( P = 0.003) tumours in men only. Nephroureterectomy was performed in 41.3% of the cases and there was an increasing trend to endoscopic surgery ( P = 0.019), although the absolute number was low. CONCLUSION

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Trends in epidemiology and treatment of upper urinary tract tumours in the Netherlands 1995–2005: an analysis of PALGA, the Dutch national histopathology registry

et al. 2010

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“…Compared to bladder cancer, significantly fewer studies have discussed the connection between UTI and renal pelvis/ureter cancer because of its relative rarity. Studies regarding this issue showed either non‐significant findings or inconclusive results …”

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confidence: 99%

“…Studies regarding this issue showed either non-significant findings (13) or inconclusive results. (14) Several mechanisms were proposed for explaining the association between infection and bladder cancer. (11,12) First, chronic inflammation of the bladder may induce urinary retention and stasis, which can potentially increase exposure and absorption of carcinogens present in the urine.…”

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confidence: 99%

Urinary tract infection increases subsequent urinary tract cancer risk: A population‐based cohort study

et al. 2013

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This study examines the possible association between urinary tract infection (UTI) and urinary tract cancer (UTC). Data from the National Health Insurance system of Taiwan were used for the analysis. The UTI cohort included 70 116 patients who were diagnosed and recruited between 1997 and 2010. Each patient was randomly frequency-matched with two people without UTI from the general population based on their age, sex, and month of UTI diagnosis. Cox's proportional hazard regression analysis was used to estimate the effects of UTI on UTC risk until the end of follow-up on December 31, 2010. Patients with UTI had a significantly higher risk of developing UTC than healthy people (adjusted hazard ratio, 4.66; 95% confidence interval, 3.55-6.10). Further analyses indicated that risks are potentially related to the level of the lesion site. This study indicated that patients with UTI had a higher risk of developing UTC. (Cancer Sci 2013; 104: 619-623) U rinary tract infection (UTI) is the most common extraintestinal infectious disease entity in women worldwide. Approximately 50% of women have at least one symptomatic UTI during their lifetime, and recurrent episodes are common.(1) Several infections are related to the development of cancer, including human papilloma virus-associated cancer such as head and neck cancers, cervical cancer, (2,3) hepatitis B and C virus-associated liver cancer, (4,5) Epstein-Barr virusrelated nasopharyngeal carcinoma and lymphoma, (6) and Helicobacter pylori infection-induced gastric cancer. (7) Chronic inflammation induced by bladder infection could have a role in human bladder cancer development. (8,9) The relationship between schistosomiasis and bladder cancer has been confirmed.(10) Several case-control studies focused on the connection between UTI and bladder cancer risk and, although most showed that patients with UTI had a higher risk of bladder cancer, results were inconsistent. (11,12) Compared to bladder cancer, significantly fewer studies have discussed the connection between UTI and renal pelvis ⁄ ureter cancer because of its relative rarity. Studies regarding this issue showed either non-significant findings (13) or inconclusive results.Several mechanisms were proposed for explaining the association between infection and bladder cancer. (11,12) First, chronic inflammation of the bladder may induce urinary retention and stasis, which can potentially increase exposure and absorption of carcinogens present in the urine.(15) Second, bacterial flora in the urine may contribute to the production of nitrites that are converted to carcinogenic nitrosamines. (16) This study attempts to determine if there is a higher risk of bladder cancer for patients with UTI by examining a Taiwanese cohort. Because of an unusually high incidence of upper urinary tract urothelial carcinoma in Taiwan, (17) upper urinary tract cancer was of primary interest, but ensuing investigations were extended to cover all urinary tract cancers (UTC) except renal cell carcinoma. The results in this study were g...

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“…Urothelial carcinomas are more closely associated with lifestyle factors, whereas non-urothelial carcinoma bladder cancers are often associated with infections, foreign bodies or invasive cancers from neighboring organs (16). Ninety percent of all cancers that occur in the bladder (17)(18)(19) and in the urothelium of the upper urinary tract (20) are urothelial carcinoma. Due to the common epithelium of origin, all urothelial carcinoma have similar risk factors (18,21).…”

Section: Introductionmentioning

confidence: 99%

Effects of Radiation and Lifestyle Factors on Risks of Urothelial Carcinoma in the Life Span Study of Atomic Bomb Survivors

Grant

Ozasa

Preston³

et al. 2012

Radiation Research

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Carcinoma of the renal pelvis and ureter

Cited by 19 publications

References 24 publications

Trends in epidemiology and treatment of upper urinary tract tumours in the Netherlands 1995–2005: an analysis of PALGA, the Dutch national histopathology registry

Trends in epidemiology and treatment of upper urinary tract tumours in the Netherlands 1995–2005: an analysis of PALGA, the Dutch national histopathology registry

Urinary tract infection increases subsequent urinary tract cancer risk: A population‐based cohort study

Effects of Radiation and Lifestyle Factors on Risks of Urothelial Carcinoma in the Life Span Study of Atomic Bomb Survivors

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