Long-term results of simple enucleation for the treatment of small renal cell carcinoma

Abstract

Simple tumor enucleation is a safe and acceptable approach for elective NSS. It provides excellent long-term progression-free and cancer specific survival rates, and is not associated with an increased risk of local recurrence compared to partial nephrectomy.

Histopathologic Analysis of Peritumoral Pseudocapsule and Surgical Margin Status after Tumor Enucleation for Renal Cell Carcinoma

“…These prospective data explain the excellent results of TE for treating pT1a and pT1b tumors, similar to the results of enucleoresection and RN previously reported in retrospective studies [17][18][19][20][21][22][23]. We have routinely performed TE at our institution since the early 1980s, reporting excellent long-term, progression-free, and cancer-specific survival rates with a mean follow-up of the more recent publications ranging between 74 mo and 88 mo [20][21][22].…”

“…Recently, other retrospective analyses confirmed that TE can be safely used for treating pT1a-pT1b RCC tumors, and it is not associated with any greater risk of local recurrence than is partial nephrectomy [20][21][22][23]. Therefore, the discrepancy between the optimal oncologic results of in vivo TE reported in several recent retrospective analyses [20][21][22][23] and the pathologic concerns of incomplete tumor excision based on data obtained by studies after an ex vivo TE or tumor sections of RN specimens remains an unsolved oncologic issue in conservative kidney surgery [8,[9][10][11].…”

Morbidity of tumour enucleation for renal cell carcinoma (RCC): results of a single‐centre prospective study

“…In recent years, several papers showed the lack of correlation between the width of the resection margin and the risk of local recurrence [8,9]. In this scenario, some studies have supported the oncological efficacy of the tumour enucleation (TE) technique, defined as the blunt excision following the natural cleavage plane between the tumour capsule and normal parenchyma, based on larger retrospective series that showed a disease‐free survival equivalent to standard NSS (Level of Evidence 3) [10–13], and on prospective studies that confirmed its safety from a pathological perspective (Level of Evidence 2b) [14].…”

Tumour enucleation vs partial nephrectomy: Long term results

“…Several retrospective studies have confirmed good oncologic results of SE and some of these studies have demonstrated also a similar local recurrence-free survival and cancer specific survival rates between SE and standard PN, for renal tumors with clinical diameter up to 7 cm; one study have also confirmed similar cancer specific survival between SE and radical nephrectomy [18][19][20][21][22][23][24][25].…”