Role of vitamins, minerals and supplements in the prevention and management of prostate cancer

Santillo, Vincent M.; Lowe, Franklin C.

doi:10.1590/s1677-55382006000100002

Cited by 30 publications

(26 citation statements)

References 80 publications

(100 reference statements)

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“…In this direction, lot of academic and global federal efforts are going on to establish the long term benefits of nutraceuticals in prostate cancer risk [140][141][142][143][144][145]. The increased awareness and self-prescription of nutraceuticals among public for prostate cancer benefits is present major concern of health authorities [146][147][148][149][150][151][152][153].…”

Section: Cancers In the Human Body And Nutraceutical Protectionmentioning

confidence: 99%

Nutraceuticals and Nutraceutical Supplementation Criteria in Cancer: A Literature Survey

Sharma¹

2009

TONUTRAJ

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Nutraceuticals are natural and bioactive products with food value to keep energy balance in the body and promise substantial therapeutic value in several diseases. Major nutraceuticals are now part of nutrition supplements at nonprescription counters and their self-prescription is increased at large scale. The current literature suggests the nutraceutical use in most of cancer prevention and management. The biochemical mechanism of nutraceuticals is poorly reported and most of the literature indicates the success of nutaceuticals in experimental animals. Broadly nutraceuticals are antioxidants, omega-3 fatty acids, vitamins, minerals and dietary fibers. Most of the nutraceuticals are derived from plants and animal origin and act as biochemical metabolites either by direct intermediary metabolism or regulating immunity.

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Section: Cancers In the Human Body And Nutraceutical Protectionmentioning

confidence: 99%

Nutraceuticals and Nutraceutical Supplementation Criteria in Cancer: A Literature Survey

Sharma¹

2009

TONUTRAJ

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“…A lot of samples of them in the range of less than one Joule to some Megajouls have been constructed in different research centers all over the world [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…In general, the different phases of discharge in Plasma Focus devices can be divided to five different stages [1,2,3,8,12]: 1 -The initial breakdown and surface discharge , very little is known about the physics of this phase [13], this phase has a great influence on the formation of final pinch , 2 -rundown phase that does not exist in Filippov-type devices, 3 -radial compression , 4 -pinch phase , 5 -instability happening and pinch destruction. In this paper we would present and analyze the results of initial breakdown & surface discharge phase in "Dena" Filippov-type Plasma Focus Facility (90 kJ, 25 kV) in different working conditions.…”

Section: Introductionmentioning

confidence: 99%

Experimental results of breakdown in "Dena" plasma focus device

Goudarzi¹,

Hoseinian²,

Raeisdana³

2014

J. Phys.: Conf. Ser.

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Abstract. In spite of the intense research activities on Plasma Focus devices, the physics of the initial breakdown and surface discharge phase has not been realized completely. In this paper we have analyzed the surface discharge and initial breakdown phase in Filippov-type Plasma Focus Facility "Dena" (90 kJ, 25 kV) on the base of the current and current derivative measured signals by using Argon, Neon and Krypton as working gases at different discharge voltages and gas pressures, and the effects of working conditions (atomic weight, discharge voltage and gas pressure) on the breakdown and surface discharge phase have expressed. Also, on the base of these results, we have investigated about the relation of this phase with final pinch phase.

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“…African ancestry), and family history of PCa [8,9]. Role of different dietary factors in PCa development has been studied; these include -supplementation with minerals like Calcium, Selenium, Zinc, Vitamins such as A, D, E; intake of soy, green tea, tomato-rich products (lycopene) and alpha-lenoleic acid, as well as dietary lipids [9][10][11][12][13]. Diet that includes fruits, vegetables (tomatoes, legumes), selenium, vitamin E and D have been suggested to decrease the risk of PCa.…”

Section: Introductionmentioning

confidence: 99%

Molecular Genetic Etiology of Prostate Cancer

Pethe¹,

Bapat²

2008

TOGENJ

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Prostate Cancer (PCa) is the most frequently diagnosed non-skin cancer and second leading cause of cancer deaths after lung cancer in the western industrialized countries. It varies widely by geographic location and ethnicity. It is clinically heterogeneous, complex and indeed a multi-factorial disease. While the majority of PCa is sporadic, as much as up to 40% of the cases are associated with some form of genetic susceptibility. It is clear today that etiology of PCa involves several genetic loci with no single major gene accounting for a large proportion of susceptibility to the disease. In particular, allelic variations in four genes, namely RNASEL (1q25), MSR1 (8p22), ELAC2 (17p11) and EphB2 (1p36) have been shown to be associated with increased susceptibility to PCa. Also, tumors harboring mutations in these genes present with more aggressive clinical features and poor outcome. Recently, novel genetic alterations in prostate cancer patients have been identified -these include gene fusions involving the prostate-specific gene transmembrane protease, serine 2 (TMPRSS2) and members of the erythroblastosis virus E26 transforming sequence (ETS) family of transcription factors. This predominant molecular subtype is considered to be an early event in PCa, and emerging evidence demonstrates its potential in prostate cancer detection, stratification and treatment. In addition to gene fusions, there is compelling evidence demonstrating 8q24 region as a prostate cancer susceptibility locus and markers at this locus are statistically significantly associated with an increased PCa risk in different ethnic groups. Genotyping of SNPs / markers in a predefined 8q24 region as well as genome-wide association studies have implicated several polymorphisms ( rs7008482, rs1447295, rs16901979, rs698367) in this region as risk factors for PCa. In additions to genetic alterations, frequent epigenetic aberrations such as DNA hypermethylation of tumor suppressor genes has been observed in PCa affecting the expression and function of a battery of genes leading to tumorigenesis, tumor progression and metastasis. In this review, we highlight some of the recent advances in molecular genetic etiology of PCa including promising candidate hereditary PCa susceptibility genes, novel gene fusions in acquired PCa, 8q24 susceptibility locus, as well as examine current literature regarding epigenetic changes leading to prostate cancer development and progression.

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Role of vitamins, minerals and supplements in the prevention and management of prostate cancer

Cited by 30 publications

References 80 publications

Nutraceuticals and Nutraceutical Supplementation Criteria in Cancer: A Literature Survey

Nutraceuticals and Nutraceutical Supplementation Criteria in Cancer: A Literature Survey

Experimental results of breakdown in "Dena" plasma focus device

Molecular Genetic Etiology of Prostate Cancer

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