Pathology

Abstract

Editorial CommentWhile the first paper deals with selective management of gunshot wounds to the back and abdomen, this paper centers on gunshot wounds to the pelvis. It is a much smaller study of only 37 patients, and as in the 2001 study cited previously, patients only had laparotomy if they had peritoneal signs, hemodynamic instability, gross hematuria or rectal bleeding. 51% got immediate operation and 49% were observed. 3/18 (17%) of those observed required exploration for peritoneal signs, but all 3 were nontherapeutic! So, once again this group turns what we know about trauma on its head. If you pick the correct physical exam signs to trigger surgery, you can avoid unnecessary laparotomy in about half of patients with gunshot to the pelvis. I must repeat, I think this is amazing. I think data such as this can give us the strength to "sin boldly" in our own world of genitourinary trauma, and determine which of our signs and symptoms predict who will not need operating. Background: We aimed to determine whether the extent of needle biopsy sampling both on the initial biopsy that showed HGPIN and on re-biopsy would influence the detection rate of cancer.Design: 4,237 patients with an initial diagnosis of only HGPIN on needle biopsy were identified; patients who in addition to HGPIN had a focus of atypical glands, suspicious for cancer were excluded. Of these, 937 patients had at least one follow up biopsy and were the subject of this study. The mean age was 67.5 (range from 39 to 87 years). The mean interval from diagnosis of HGPIN to rebiopsy was 4.8 months. In the initial biopsy resulting in a diagnosis of HGPIN, 371 men had > 8 cores (median 10; range 8-26) and 399 men had 6 core sampling.Results: Not taking into account the number of cores on rebiopsy, in the 6 core initial sampling group, the risk of cancer on rebiopsy was 22.1% versus 15.1% in the > 8 core group (p value = 0.013). The table shows the combined influence of numbers of cores in the initial and rebiopsy sampling.

Effect of pH and Additives on the Compatibility between Vancomycin and Furosemide Injections

“…1,2) This phenomenon can lead to closure of the administration route, reduce the eŠect of drugs, and damage tissue.…”

Particle Condition Change in Emulsion Admixture Evaluated by <i>in Situ</i> Flow Particle Imaging Analysis

“…The preparation process (dilution and dissolution of a drug in an infusional diluent) can result in physicochemical incompatibility and affect the stability of the drug. [1][2][3] Intravenous emulsions are used in the delivery of both nutritional supplements and in the preparation of drugs with low water solubility. 4) The admixing of an intravenous emulsion with another component is not recommended by manufacturers because it usually results in instability of the emulsion.…”