Economical impact of orchiectomy for advanced prostate cancer

Paula, Adriano Augusto Peclat de; Piccelli, Hilton R. S.; Pinto, Nilson P.; Teles, Antônio Gomes; Franqueiro, Antonio G.; Maltez, Adriano R. L.; Silva, Jose H.

doi:10.1590/s1677-55382003000200006

Cited by 8 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ninety per cent of testosterone is synthesized by Leydig cells of the testis, whereas 5% is formed by adrenal glands. [4] Bilateral orchidectomy is the simplest way of hormonal blockade, a procedure described by Huggins & Hodges. [5] Bilateral subcapsular orchiectomy is an inexpensive and successful modality of treatment for advanced prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Its acceptance is fairly good and its psychological effects are almost non-existent. [4] A study done by Olapade-Olaopa et al (2011) on 142 patients with histologically diagnosed prostate cancer had bilateral orchidectomy in which two specimens had evidence of testicular metastases while 106 showed evidence of testicular atrophy and 34 of the specimens were reported as normal testes. [6] In this study, all the 7 cases (30.4%) done for therapeutic purpose were revealed normal testicular histology.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Histopathological Assessment of Orchidectomy Specimens in a Tertiary Care Center

Latheef

Nayak

Nuzhath

et al. 2019

ijirms

View full text Add to dashboard Cite

Introduction: Orchidectomy is a medical procedure to remove one or both testicles in males.The testis can be removed for torsion/infarction,infection,therapeutic castration for prostate cancer,cryptorchidism and tumor.In our study we did a histomorphological study these lesions which is a rare surgery other than therapeutic purpose. Aims & Objectives: The aim of our study was to emphasise the clinical, radiological and histomorphological features of the rare orchiectomy procedure in various conditions of testis and to find out the clinical relevance. Materials & Methods: This was a retrospective and prospective analysis done for 18 months (January 2016-June 2017). All orchidectomy specimens received in the Department of Pathology were analyzed with respect to clinical indications,radiology,morphology and microscopic features. Results: Out of a total of 23 orchidectomy cases 16 were unilateral and 7 bilateral.Most common age group was 50 to 70 years(13).The youngest and eldest patients were 6 & 89 years respectively.The most common etiology was therapeutic(7 cases of carcinoma prostate ), torsion in 6,epididymo-orchitis in 3,benign tumours in 2,inflammtory causes in 3 and one case of cryptorchidism. Conclusion: Our study helped us to assess and evaluate the clinical relevance of orchidectomy by histomorphological study of these lesions and to defer the procedure in certain non-tumoral cases for the benefit of the patient.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Histopathological Assessment of Orchidectomy Specimens in a Tertiary Care Center

Latheef

Nayak

Nuzhath

et al. 2019

ijirms

View full text Add to dashboard Cite

show abstract

“…20 The economic advantage of treatment by BSCO when compared to other forms of hormone manipulation has been recognised in the past, 21 and the cost-effective advantage of BSCOs over long-term LHRH agonist treatment has been recognised in various currencies and health care systems. 17,[22][23][24] The survival period needed to realise the economic benefit was nine months in the United States 21 and two years in Norway. 16 The cost of a BSCO on the NHS is comparable to the cost of one year's worth of LHRH agonists or antagonists without including the cost of delivery.…”

Section: Discussionmentioning

confidence: 99%

Surgical castration for androgen-deprivation therapy of prostate cancer – relevance in current practice

Rajasundaram

Gunendran

George

2013

Journal of Clinical Urology

View full text Add to dashboard Cite

Objective: Rapid control of the disease is essential in the management of patients with critical and symptomatic metastatic prostate cancer. Pharmacological castration has become the main form of androgen-deprivation therapy (ADT) for prostate cancer, with luteinising hormone-releasing hormone (LHRH) agonists being used in more than 90% of cases. Surgical castration has become the less preferred modality. This article aims to explore the clinical and economic advantages of bilateral sub-capsular orchidectomy (BSCO). Method: Pre-and post-operative serial testosterone levels were taken from patients who had BSCO for adenocarcinoma of the prostate. The half-life of testosterone was calculated. The cost of surgical castration on the National Health Service (NHS) was compared to the cost of LHRH agonists. Results: Ten patients with a median prostate-specific antigen (PSA) level of 93 ng/ml (range 26 to 4557 ng/ml) were included. Their mean random pre-operative testosterone level was 13.8 ng/ml (range 6.8 to 21.8 ng/ml). The mean halflife of testosterone was 61.7 minutes when calculated from the first two hours, and 67 minutes when calculated from the total drop with no significant variation (p = 0.464). Four patients reached castrate levels of testosterone within four to six hours. The total cost of an inpatient BSCO in the NHS was £850 to £1154. This was more or less equivalent to one year's worth of the commonly used LHRH agonists without including the cost of medical services. Conclusions: Testosterone has a short half-life and reaches castrate levels within hours of the BSCO procedure. Rapid castration by BSCO would benefit patients with critical metastatic disease. BSCO on the NHS in patients with more than one year of life expectancy is also economically beneficial.

show abstract

“…Allerdings kann hier auch klar konstatiert werden, dass sich die Orchiektomie bei ihrer geringen Komplikationsrate hervorragend als eine rein ambulante Prozedur eignet. Momentan wird dann dieser Eingriff mit Kosten bis maximal 142 E vergütet, die ambulante Durchführbarkeit konnte in vielen Untersuchungen bestätigt werden [26,30]. Festzuhalten bleibt außerdem, dass gemäß dem Prüfkatalog (G-AEP) der Spitzenverbände der Krankenkassen und der Deutschen Krankenhaus-Gesellschaft die Forderung besteht, jeden skrotalen Eingriff am männlichen Genitale bei Patienten mit geringer Komorbidität im ambulanten Modus durchzuführen ( § 115 b SGB V).…”

Section: Diskussionunclassified

Die Orchiektomie in der Primärtherapie des metastasierten Prostatakarzinoms - ein anachronistischer Eingriff?

May¹,

Kheyri²,

Seehafer³

et al. 2005

Gesundh ökon Qual manag

View full text Add to dashboard Cite

Economical impact of orchiectomy for advanced prostate cancer

Cited by 8 publications

References 10 publications

Histopathological Assessment of Orchidectomy Specimens in a Tertiary Care Center

Histopathological Assessment of Orchidectomy Specimens in a Tertiary Care Center

Surgical castration for androgen-deprivation therapy of prostate cancer – relevance in current practice

Die Orchiektomie in der Primärtherapie des metastasierten Prostatakarzinoms - ein anachronistischer Eingriff?

Contact Info

Product

Resources

About