Recombinant gonadotropin therapy to improve spermatogenesis in nonobstructive azoospermic patients – A proof of concept study

Laursen, Rita Jakubcionyte; Alsbjerg, Birgit; Elbæk, Helle Olesen; Povlsen, Betina Boel; Jensen, Kirsten Brock Spanggaard; Lykkegaard, Jette; Esteves, Sandro C.; Humaıdan, Peter

doi:10.1590/s1677-5538.ibju.2022.99.13

Cited by 10 publications

(4 citation statements)

References 45 publications

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“…Sperm harvested from the seminiferous tubules are cryopreserved for future use. Our preferred method for freezing testicular sperm is vitrification using 'The Cell Sleeper method' (9,27,28). Briefly, Cell Sleepers consist of an outer vial, an inner tray, and a screw cap.…”

Section: Our Clinical Approachmentioning

confidence: 99%

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Microdissection TESE versus conventional TESE for men with nonobstructive azoospermia undergoing sperm retrieval

Esteves

2022

Int. braz j urol.

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Section: Our Clinical Approachmentioning

confidence: 99%

“…For these reasons, we do not support the routine use of TESA for NOA males. However, TESA is still carried out, for example, in low resource centers, particularly in patients with a history of previous positive retrieval by TESA or a biopsy report showing hypospermatogenesis (7,9).…”

Section: Introductionmentioning

confidence: 99%

Microdissection TESE versus conventional TESE for men with nonobstructive azoospermia undergoing sperm retrieval

Esteves

2022

Int. braz j urol.

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“…Combining hCG with FSH may be beneficial in these patients as hCG boosts intratesticular testosterone production. Some patients with nonobstructive azoospermia fitting this group have experienced improvements in sperm retrieval rates after hormonal treatment ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Approaching treatment of male infertility: the APHRODITE criteria

Esteves,

Humaidan

2024

Int. braz j urol.

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The Need for Improved ClassificationMale infertility is a complex clinical condition, and thus far, the clinical management of men with reduced fertility and impaired spermatogenesis has been fraught with difficulties and limited advancement (2). This has led to frustration among both clinicians and patients, perpetuating the belief that intracytoplasmic sperm injection (ICSI) is the only solution to provide the couple with a baby without the need to explore the nature or cause of the underlying male infertility (3, 4). The APHRODITE criteria aim to address this gap by providing a structured approach to characterize male infertility in men seeking paternity, particularly those who may benefit from hormonal treatment (1). Importantly, these criteria are not designed for men with established infertility diagnoses, such as varicocele, infection, or obstruction, who would not benefit from hormonal treatment (3). The Role of Hormones in SpermatogenesisUnderstanding the APHRODITE criteria begins with a brief review of human spermatogenesis, a complex process that takes approximately 75 days and is primarily controlled by follicle-stimulating hormone (FSH) and luteinizing hormone (LH)-driven testosterone (5). These hormones are crucial in regulating spermatogenesis, making them central to our approach.

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“…Dr. Laursen and colleagues from Denmark and Brazil performed in page 471 (5) a nice study about the recombinant gonadotropin therapy to improve spermatogenesis in nonobstructive azoospermic patients and concluded that hormonal therapy with recombinant gonadotropins could be considered in infertile men with nonobstructive azoospermy as an alternative to sperm donation. Large-scale studies are needed to substantiate hormone stimulation therapy with recombinant gonadotropins in routine clinical practice for this severe form of male infertility.…”

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Upper tract urothelial carcinoma and bladder cancer in review in this number of International Brazilian Journal of Urology

Favorito

2022

Int. braz j urol.

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and Egypt, and as usual the editor´s comment highlights some of them.In the present issue we present two important reviews about upper urothelial carcinoma (UUC) and bladder cancer. The paper about UUC of the group of Dr. Sharma from India in page 406 shows a very complete systematic review about the topic (1). The authors shows that the tumor grade, stage, presence of lymphovascular invasion, lymph node metastasis, hydronephrosis, variant histology, sessile architecture, margin positivity and multifocality were associated with poor recurrence free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Presence of carcinoma in situ was associated with poor RFS and CSS but not OS. Tumor necrosis was associated with worst CSS and OS but not RFS. Tumor location was not a predictor of any of the survival parameters. Dr. Korkes and colleagues from Brazil and USA in page 397 (2) in a interesting narrative review about bladder cancer shows that patients with low-grade-non-muscle-invasive bladder cancer that TURBTs, chemoablation, BCG immunoablation, partial cystectomy, radical cystectomy, radiotherapy, and chemotherapy are attractive modalities to treat them effectively and proposes an algorithm to overcome these challenges. The editor in chief would like to highlight the following works too:Dr. Mazzucchi and colleagues from Brazil and Canada, presented in page 456 (3) a nice review about the single use flexible ureteroscopes and concluded that these ureteroscopes are lighter and have superior quality of image when compared to fiberoptic ones and that there are no definite data showing a higher stone-free rate or less complications with the use of single-use flexible ureteroscopes.Dr. Sobrinho and colleagues from the Urogenital Research Unit from Brazil performed in page 561 (4) a interesting translational study about the lower pole anatomy in anomalous kidneys and concluded that the knowledge of spatial anatomy of lower pole is of utmost importance during endourologic procedures in patients with kidney anomalies. The horseshoe kidneys had more restrictive anatomic factors in lower pole than the complete ureteral duplication.

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Recombinant gonadotropin therapy to improve spermatogenesis in nonobstructive azoospermic patients – A proof of concept study

Cited by 10 publications

References 45 publications

Microdissection TESE versus conventional TESE for men with nonobstructive azoospermia undergoing sperm retrieval

Microdissection TESE versus conventional TESE for men with nonobstructive azoospermia undergoing sperm retrieval

Approaching treatment of male infertility: the APHRODITE criteria

Upper tract urothelial carcinoma and bladder cancer in review in this number of International Brazilian Journal of Urology

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