The role of intra-abdominal pressure in human testicular migration

Logsdon, Natasha T; Sampaio, Francisco J.B.; Favorito, Luciano A.

doi:10.1590/s1677-5538.ibju.2021.99.03

Cited by 8 publications

(5 citation statements)

References 47 publications

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“…Testicular descent is a multifactorial and complex event that is important for testicular development and can prevent the occurrence of UDT. 14 Although some clinical and experimental reports have suggested that increased intra-abdominal pressure during fetal development contributes substantially to testicular descent, few studies have investigated the clinical factors related to UDT with gastroschisis. 15 In the present study, we used the parameters of gastroschisis severity, which may reflect intra-abdominal pressure.…”

Section: Discussionmentioning

confidence: 99%

Clinical factors related to undescended testis in infants with gastroschisis

Umeda

Takayama

Takase

et al. 2022

Pediatrics International

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Background: Recent studies have reported the high incidence of undescended testis (UDT) in patients with gastroschisis. Although various mechanical, hormonal, and genetic theories have been postulated to describe testicular descent, the mechanism contributing to this condition remains controversial. We aimed to investigate the incidence and risk factors of UDT in infants with gastroschisis. Methods: Male neonates who underwent surgery for gastroschisis between January 1982 and December 2019 were enrolled. Data were analyzed regarding the prevalence of UDT, including spontaneous testicular descent and the necessity of orchidopexy. Patients were grouped into those with or without UDT to identify the risk factors for UDT. Results: Among 38 patients with gastroschisis, six (15.8%) developed UDT. There were no significant differences in gestational age or birthweight between patients with and without UDT. The patients with UDT had a significantly larger defect size than those without UDT (P = 0.037). In addition, the timing of abdominal closure was significantly later in patients with UDT than in those without UDT (P = 0.004). None of the patients with UDT exhibited spontaneous testicular descent requiring subsequent orchidopexy. Conclusions: Patients with gastroschisis had a high prevalence of UDT. In gastroschisis, the incidence of UDT was related to the defect size and the timing of abdominal wall closure, indicating that an insufficient increase in intraabdominal pressure during the fetal period may affect the development of UDT.

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Section: Discussionmentioning

confidence: 99%

Clinical factors related to undescended testis in infants with gastroschisis

Umeda

Takayama

Takase

et al. 2022

Pediatrics International

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“…Patients with omphalocele have a high prevalence of associated anomalies, while gastroschisis is associated with malformations outside the gastrointestinal tract in around 10% of the cases, and with abnormalities related to the gastrointestinal tract in up to 25% of cases [21][22][23] . Although our AWDs sample was small, from 8 cases of gastroschisis studied, we found 5 cases (62.5%) with anomalies not associated with the gastrointestinal tract, such as craniofacial malformations, limb agenesis and kidney anomalies.…”

Section: Discussionmentioning

confidence: 99%

“…In our sample, the organs most often herniated were liver and small intestine (91%), large intestine (82%), followed by stomach and spleen (73%). The evisceration only of the intestine classifies gastroschisis as simple, while the evisceration of other organs classifies it as complex [23][24][25][26] . Studies have shown that this complex condition is correlated with an increase in the mortality rate 27-30 . Our findings suggest that the area of the abdominal wall defect (hole) in gastroschisis and omphalocele was not a predictor of the number of herniated abdominal organs.…”

Section: Discussionmentioning

confidence: 99%

Investigation of a connection between abdominal wall defects and severity of the herniation in fetuses with gastroschisis and omphalocele

Logsdon

Gallo

Favorito

et al. 2021

Sci Rep

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Analyze the biometric parameters and the size (area) of abdominal wall defect (AWD) in fetuses with gastroschisis and omphaloceles and correlate them with the herniated internal organs. We studied 22 fetuses (11 with AWDs and 11 without anomalies). In all fetuses we evaluated the xiphopubic distance (XPD) and iliac crest distance (ICD). In fetuses with AWDs we dissected the abdominal wall and measured the width and length of the defect for calculating its area and studying the correlation between the size of the defect with the organs that were herniated. For statistical analysis, the Anova and Tukey post-test were used (p < 0.05). The XPD in the control group had mean of 4.2 mm (2.3–5.9; SD ± 1.11), while in the AWDs it was 4.2 mm (2.9–5.5; SD ± 0.98) (p = 0.4366). The ICD had mean values of 2.5 mm (1.6–3.4; SD ± 0.58) in the control group, and 2.3 mm (1.2–3.0; SD ± 0.56) in AWDs fetuses (p = 0.6963). The number of herniate organs do not have significant correlation with the area of the defect (r2 = 0.2504, p = 0.5068). There is no correlation between the size (area) of abdominal wall defects and the number of the internal organs that herniated. Therefore, the hole size is not a predictor of the severity of the gastroschisis or omphalocele.

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“…Gastroschisis is a paraumbilical abdominal wall defect associated with protrusion of the abdominal content through a defect which cause is not completely elucidated, but there is evidence of an abnormality in the formation and development of the ventral body wall during embryogenesis, resulting in bowel herniation (1). Patients with gastroschisis are associated with malformations outside the gastrointestinal tract in around 10% of the cases, and with abnormalities related to the gastrointestinal tract in up to 25% of cases (2,3). The association of gastroschisis and undescended testis probably occurs by mechanical factors rather than prematurity (4).…”

Section: Commentmentioning

confidence: 99%