The effect of vitamin D deficiency in children with overactive bladder related urinary incontinence

Abstract

Purpose: Overactive bladder (OAB) is a common syndrome associated with lower urinary tract symptoms (LUTS), especially urinary incontinence in children, which may affect the patient's quality of life (QoL). Vitamin D deficiency has been shown to be associated with OAB syndrome. This study evaluated the relationship between vitamin D status and OAB-related symptoms and QoL in children. Materials and Methods:The study included 52 pediatric patients with OAB-related urinary incontinence and 41 healthy children. LUTS were assessed using the Dysfunctional Voiding and Incontinence Symptoms Score (DVISS) questionnaire, and QoL was assessed using the Pediatric Incontinence Questionnaire (PINQ). Oral vitamin D supplementation was given to patients with OAB with vitamin D deficiency. Urinary symptoms and QoL were evaluated before and after vitamin D supplementation. Results: Vitamin D deficiency was more common in the OAB group (75%) than in the control group (36.6%). Logistic regression analysis revealed that vitamin D status (<20ng/ mL) was a significant predictor of OAB. Both pre-treatment and post-treatment DVISS and PINQ scores showed a positive correlation. After vitamin D supplementation, 8 (23.5%) patients had a complete response and 19 (55.9%) patients had a partial response. Significant improvement in QoL was also achieved. Conclusions: Vitamin D deficiency is more common in children with urinary incontinence and OAB than in healthy children. Although vitamin D deficiency is not routinely evaluated for every patient, it should be evaluated in treatment-resistant OAB cases. Vitamin D supplementation may improve urinary symptoms and QoL in patients with OAB.

Efficacy and Safety of High-Dose Vitamin D Supplementation vs Solifenacin or Standard Urotherapy for Overactive Bladder Dry in Children: A Randomized Clinical Trial

“…12 Similar to previous findings in children, our results also suggested that the subset with lower vitamin D levels (below 20 ng/mL) demonstrated an augmented voiding frequency at the initial visit and a heightened effectiveness compared to the cohort possessing higher vitamin D levels (20-35 ng/mL) after VDS intervention. 14 No discernible difference emerged in the primary outcomes between the “never group” and the “ever group,” stratified by their VDS history, nor between the “worse response group” and the “better response group,” categorized by whether vitamin D levels surpassed 10 ng/mL following supplementation. Recognizing the constraints of post-hoc analyses and potential disparities in baseline, these findings warrant careful interpretation.…”

“…13 Moreover, a recent trial showed a treatment benefit of high-dose VDS in reducing OAB-related incontinence in children with vitamin D deficiency. 14 However, whether high-dose VDS is effective and safe in mitigating OAB-dry symptoms in children with lower vitamin D levels remain unknown.…”

The precision of robotic surgery in International Brazilian Journal of Urology

“…Dr. Özçift and colleagues from Turkey presented in page 316 (8) a nice sudy about the relationship between vitamin D status and Overactive bladder (OAB)-related symptoms and quality of life (QoL) in children and concluded that Vitamin D deficiency is more common in children with urinary incontinence and OAB than in healthy children. Although vitamin D deficiency is not routinely evaluated for every patient, it should be evaluated in treatment-resistant OAB cases.…”