Editorial Comment: Adjuvant Single-Dose Upper Urinary Tract Instillation of Mitomycin C After Therapeutic Ureteroscopy for Upper Tract Urothelial Carcinoma: A Single-Centre Prospective Non-Randomized Trial

Abstract

This article aims to demonstrate the efficacy of mitomycin C infusion right after the ureteroscopy procedure for ablation of urothelial carcinomas in patients submitted to kidney preservation protocol. Fifty-two patients were enrolled from April 1, 2015 to August 31, 2018, submitted to laser ablation followed by a single dose of mitomycin-(ASDM). The study was approved by the ethics committee. All patients with urothelial lesion < T2 and those in which endoscopic resection seemed to be feasible were included. Patients with bladder lesions greater than 3.0 cm or incomplete ablation of the upper urinary tract were excluded. The control group was composed of patients with mitomycin C intolerance but with similar radiological aspects. The technique was described as intravenous antibiotic prophylactic therapy with second-generation cephalosporin, 30 minutes before surgery. Initial cystoscopy and trans urethral bladder resection (TUR-B) after ureteroscopy if necessary. Semi rigid ureteroscope was used for tumors of the distal third of the ureter and flexible ureteroscope with the use of an access sheath when ablation in the pelvis, renal