Dietary and circulating vitamin D and risk of renal cell carcinoma: a meta-analysis of observational studies

Wu, Jing; Yang, Nan Ping; Yuan, Mingxin

doi:10.1590/s1677-5538.ibju.2020.0417

Cited by 13 publications

(3 citation statements)

References 51 publications

(73 reference statements)

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“…Furthermore, initial PT2385 administration to a patient suffering metastatic renal carcinoma (ccRCC), followed by a Phase I clinical trial in patients with advanced ccRCC, PT2385 showed promising efficacy and tolerability as monotherapy [ 220 , 221 ]. Consistently, a recent meta-analysis of nine previous studies showed an inverse correlation between circulating and dietary vitamin D levels and the occurrence of ccRCC [ 222 ], suggesting that a combination of HIF inhibitors (including natural compounds such as flavonoids, celastrol, and resveratrol [ 223 , 224 , 225 ]) and calcitriol could be a potential anticancer strategy to treat ccRCC.…”

Section: Cancer–hypoxia–vitamin Dmentioning

confidence: 55%

Vitamin D and Hypoxia: Points of Interplay in Cancer

Gkotinakou

Mylonis

Tsakalof

2022

Cancers

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Vitamin D is a hormone that, through its action, elicits a broad spectrum of physiological responses ranging from classic to nonclassical actions such as bone morphogenesis and immune function. In parallel, many studies describe the antiproliferative, proapoptotic, antiangiogenic effects of calcitriol (the active hormonal form) that contribute to its anticancer activity. Additionally, epidemiological data signify the inverse correlation between vitamin D levels and cancer risk. On the contrary, tumors possess several adaptive mechanisms that enable them to evade the anticancer effects of calcitriol. Such maladaptive processes are often a characteristic of the cancer microenvironment, which in solid tumors is frequently hypoxic and elicits the overexpression of Hypoxia-Inducible Factors (HIFs). HIF-mediated signaling not only contributes to cancer cell survival and proliferation but also confers resistance to anticancer agents. Taking into consideration that calcitriol intertwines with signaling events elicited by the hypoxic status cells, this review examines their interplay in cellular signaling to give the opportunity to better understand their relationship in cancer development and their prospect for the treatment of cancer.

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Section: Cancer–hypoxia–vitamin Dmentioning

confidence: 55%

Vitamin D and Hypoxia: Points of Interplay in Cancer

Gkotinakou

Mylonis

Tsakalof

2022

Cancers

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“…We identified the following exposures associated with the incidence of RCC: healthy dietary pattern [ 64 ], unhealthy/Western pattern [ 64 ], drinking pattern [ 64 ], fish [ 65 ], total fat [ 87 ], sweetened carbonated beverage [ 66 ], beer [ 67 ], wine [ 67 ], spirits [ 67 ], riboflavin [ 68 ], vitamin B6 [ 68 ], folate [ 68 ], vitamin B12 [ 68 ], saturated fat [ 87 ], methionine [ 68 ], choline [ 68 ], betaine [ 68 ], all meats [ 15 ], tea [ 69 ], fruit fiber [ 70 ], vegetable fiber [ 70 ], cereal fiber [ 70 ], legume fiber [ 70 ], dietary inflammatory index [ 71 ], vitamin C [ 72 ], seafood [ 16 ], animal fat [ 16 ], cholesterol [ 16 ], total protein [ 87 ], animal protein [ 87 ], plant fat [ 16 ], plant protein [ 87 ], sweetened beverages (including artificially sweetened beverages and sugar-sweetened beverages) [ 73 ], polyunsaturated fat [ 87 ], vitamin E [ 74 ], coffee [ 75 ], vitamin D [ 76 ], dietary nitrate [ 77 ], dietary nitrite [ 77 ], glycemic index [ 78 ], glycemic load [ 78 ], monounsaturated fat [ 87 ], dietary fiber [ 78 ], alcohol (light) [ 79 ], alcohol (moderate) [ 79 ], alcohol (heavy) [ 79 ], alcohol (any) [ 79 ], vegetables [ 80 ], fruit [ 80 ], red meat [ 17 ], processed meat [ 17 ], cruciferous vegetables [ 81 ], poultry [ 15 , 16 ], fruit and non-starchy vegetables [ 87 ], non-starchy vegetables [ 87…”

Section: Resultsmentioning

confidence: 99%

The role of diet in renal cell carcinoma incidence: an umbrella review of meta-analyses of observational studies

Liao

Fang

Gou

et al. 2022

BMC Med

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Background Evidence associating diet with the incidence of renal cell carcinoma (RCC) is inconclusive. We aimed to summarize evidence associating dietary factors with RCC incidence and assess the strength and validity of this evidence. Methods We conducted an umbrella review of systematic reviews or meta-analyses (SRoMAs) that assessed the association between diet and RCC incidence. Through April 2021, PubMed, Web of Science, Embase, The Cochrane Library, Scopus, and WCRF were searched. Two independent reviewers selected studies, extracted data, and appraised the quality of SRoMAs. According to credibility assessment criteria, evidence can be divided into five categories: convincing (class I), highly suggestive (class II), suggestive (class III), weak (class IV), and nonsignificant (class V). Results Twenty-nine meta-analyses were obtained after screening. After excluding 7 overlapping meta-analyses, 22 meta-analyses including 502 individual studies and 64 summary hazard ratios for RCC incidence were included: dietary patterns or dietary quality indices (n = 6), foods (n = 13), beverages (n = 4), alcohol (n = 7), macronutrients (n =15), and micronutrients (n =19). No meta-analyses had high methodological quality. Five meta-analyses exhibited small study effects; one meta-analysis showed evidence of excess significance bias. No dietary factors showed convincing or highly suggestive evidence of association with RCC in the overall analysis. Two protective factors had suggestive evidence (vegetables (0.74, 95% confidence interval 0.63 to 0.86) and vitamin C (0.77, 0.66 to 0.90)) in overall analysis. One protective factor had convincing evidence (moderate drinking (0.77, 0.70 to 0.84)) in Europe and North America and one protective factor had highly suggestive evidence (cruciferous vegetables (0.78, 0.70 to 0.86)) in North America. Conclusions Although many meta-analyses have assessed associations between dietary factors and RCC, no high-quality evidence exists (classes I and II) in the overall analysis. Increased intake of vegetables and vitamin C is negatively associated with RCC risk. Moderate drinking might be beneficial for Europeans and North Americans, and cruciferous vegetables might be beneficial to North Americans, but the results should be interpreted with caution. More researches are needed in the future. Trial registration PROSPERO CRD42021246619

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“…Malnutrition is not only associated with poor postoperative outcomes, but also worse long-term survival, quality of life, and chemotherapy toxicity among oncology patients ( 25 , 26 ). Expert consensus recommends perioperative nutrition screening in elderly patients with the Mini Nutritional Assessment Short Form (MNA-SF) ( 27 ).…”

Section: Discussionmentioning

confidence: 99%