Complex Re-do robotic pyeloplasty using cryopreserved placental tissue: an adjunct for success

Abstract

_______________________________________________________________________________________ Introduction and Objectives: Management of recurrent ureteropelvic junction obstruction (UPJO) following pyeloplasty presents a challenging clinical problem. Failure of initial pyeloplasty is, in part, secondary to ureteral devascularization and subsequent fi brosis. In this video, we present a case of an anastomotic augmentation with cryopreserved placental tissue (CPT) to improve tissue healing and angiogenesis, and aid with the success of redo robotic pyeloplasty. Materials and Methods: We present a 46-year-old female with history of recurrent left-sided UPJO treated by initial endopyelotomy and then open pyeloplasty. She underwent redo robotic pyeloplasty (DaVinci Si™, Intuitive Surgical) with CPT. The patient was placed in the fl ank position; a 12mm camera port, three 8mm robotic ports, and a 12mm assistant port were used. The renal pelvis and upper ureter were mobilized to reveal a dense scar at the UPJ. A dismembered pyeloplasty was performed with barbed suture. After completion of the anastomosis, a section of CPT (Stravix™, Osiris Therapeutics) was wrapped around the anastomosis. CPT is composed of umbilical amnion and Wharton's jelly, which contains a mixture of extracellular matrix, and growth factors. The CPT is prepared and thawed on the bedside table, and placed into the peritoneum through the 12mm port in the correct orientation. The wrap is secured to the anastomosis with a fi brin sealant (EVICEL™, Johnson & Johnson). Results: The patient experienced resolution of fl ank pain. MAG3 renogram demonstrated resolution of obstruction at 6 months, with improvement of T½ time from 34 minutes to 7 minutes, with sustained improvement with repeat scan 18 months after surgery. Ureteroscopy demonstrated a patent UPJ. Strategies for successful robotic pyeloplasty after initial failed management include: (1) use of appropriate CPT agent to support the anastomosis-selection of thicker, more durable CPT to allow passage through laparoscopic port, (2) preparation on bedside table with enough time to allow thawing, (3) marking Wharton's jelly side of tissue for orientation, and (4) use of sealing agent to secure CPT to the anastomosis and prevent dislodgement. Conclusions: We demonstrate a novel approach to manage recurrent UPJ obstruction with robotic surgery using CPT. Placentaderived products may have an increasing role in the performance of complex robotic urologic reconstructive surgery.

Clinical and radiographic outcomes following salvage intervention for ureteropelvic junction obstruction

“…Robotic buccal ureteroplasty is a newer technique which was excluded from this series due to limited experience at our center (n=1), though it should be considered in salvage management of UPJO given low reported failure rates (3). Other techniques such as augmentation with cryopreserved placental tissue also have the potential to increase the probability of success (18). Additionally, the extent to which histologic features of UPJ specimens (19) or renal parenchymal biopsies (20) are associated with outcomes of salvage intervention for UPJO was not assessed in this study, and this may be an area for future research.…”