Atypical metastases from prostate cancer detected on 68Ga-PSMA PET/CT: a case series

Prostate Adenocarcinoma Metastasis to the Rectal Submucosa and Mesorectal Lymph Node on 18F-PSMA PET/CT

“…Uncommon sites include the small and large bowel, brain and spinal cord, kidneys, and spleen 4 . Superior performance of PSMA-targeted PET imaging has resulted in several reports of unusual biopsy-proven metastases, including mediastinal lymph nodes, ductus deferens, testicle, abdominal wall, and pleura 5,6 . We present a case of biopsy-proven prostate cancer metastasis to the rectal submucosa that was initially identified by PSMA-targeted PET imaging, which has been rarely reported 5 .…”

Left axillary lymphadenopathy as initial presentation of metastatic prostate cancer: A rare case report

“…Usually, prostate cancer spread locally and regionally to lymph nodes and bones [ 2 ]. It may also present as metastasis of unknown primary origin to non-regional, extra-skeletal sites rarely encountered in patients with established known prostate cancer [ 3 ]. Supra-clavicular, mediastinal, pulmonary and retro-peritoneal metastasis rarely occurs as the initial manifestation of advanced prostate cancer [ 4 ].…”

“…It may also present as metastasis of unknown primary origin to non-regional, extra-skeletal sites rarely encountered in patients with established known prostate cancer [ 3 ]. Supra-clavicular, mediastinal, pulmonary and retro-peritoneal metastasis rarely occurs as the initial manifestation of advanced prostate cancer [ 4 ]. Pelvic and abdominal retroperitoneal lymph nodes are the most common sites of adenopathy in prostate cancer [ 5 ].…”

“…Pelvic and abdominal retroperitoneal lymph nodes are the most common sites of adenopathy in prostate cancer [ 5 ]. With more advanced disease, there can be involvement of peri-aortic, intra-thoracic, supra-clavicular and cervical lymph nodes; and very rarely to axillary lymph nodes [ [3] , [4] , [5] ]. Herein, we report a case of a 40-year-old male with an advanced prostate cancer presenting with left axillary lymphadenopanthy as initial presentation and a brief review of the literature.…”

With New Technology Comes Great Responsibility: Prostate-Specific Membrane Antigen Imaging in Recurrent Prostate Cancer

“…24 Furthermore, while the anatomic sites appear atypical, similar previously subclinical findings have been reported on PSMA imaging. 26,27 Although this case may represent an extreme example, the conservative decision of not to treat with ADT and antiandrogens or chemotherapy allowed this patient to maintain his quality of life and did not result in metastatic progression on CT and Tc99 scans. Thus, as this case illustrates, several key questions remain to define the role for PSMA imaging in recurrent prostate cancer.…”