Editorial Comment: Evaluation of HIF-1α and VEGF-A expression in radiation-induced cystitis: A case-control study

Reis, Rodolfo Borges dos; Rodrigues, Antônio Antunes; Feres, Rafael Neuppmann; Muglia, Valdair Francisco

doi:10.1590/s1677-5538.ibju.2020.0054.1

Int. braz j urol.

2021

DOI: 10.1590/s1677-5538.ibju.2020.0054.1

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Editorial Comment: Evaluation of HIF-1α and VEGF-A expression in radiation-induced cystitis: A case-control study

Rodolfo Borges dos Reis

Antônio Antunes Rodrigues

Rafael Neuppmann Feres

et al.

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2022

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“…The subunits are located in the cytoplasm, and their concentration levels are correlated with low oxygen concentration levels, while the B subunit is a constructive expression, independent of oxygen concentration, mainly related to maintaining HIF structural stability and dimerization activity conformational shift [21]. Hypoxia-induced production of HIF-1 on neovascularization is currently recognized by the following mechanisms of action: preparation for angiogenesis by synthesizing vasodilation and upregulation of VEGFE and ligand expression to increase vascular permeability [22]. Upregulation of metalloprotein hydrolase activity and degradation of the extracellular matrix provide an environment for cell survival [23].…”

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Effects of Hypoxia-Inducible Factor 1 (HIF-1) Signaling Pathway on Acute Ischemic Stroke

Tao

2022

Computational and Mathematical Methods in Medicine

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Background. Epidemiological surveys show that a large number of cerebrovascular diseases occur in China every year, and among these cerebrovascular diseases, ischemic diseases are predominant. Ischemia leads to irreversible degenerative necrosis of a large number of brain neurons and severe neurological deficits. Aims. This study is aimed at exploring the mechanism of the major regulatory effect of hypoxia-inducible factor 1 (HIF-1) pathway on proangiogenesis and providing new ideas for the treatment of ischemic stroke. Materials and Methods. The rats were randomly divided into normal and ischemic control groups, and the ischemic control group was subjected to the middle cerebral artery occlusion (MCAO) cerebral ischemia model by the wire embolization method, and the rats were executed in batches at 6 h, 1 d, and 3 d after ischemia-reperfusion, and the brain tissue specimens were taken for examination to investigate the effect of hypoxia-inducible factor 1 (HIF-l) signaling pathway on acute ischemic stroke. Results. At 3 d, the number of VEGFR2 positive cells increased significantly, and there was a significant difference compared with the control group ( P < 0.05 ). At 3 d, the number of HIF-1α-positive cells increased significantly, and there was a significant difference compared with the control group ( P < 0.05 ). The number of Hes1+factor VIII positive cells in the ischemic cortex increased significantly on the 1st and 3rd day, and there was a significant difference compared with the control group ( P < 0.05 ). The expression of Hes1 protein was significantly lower than the normal level after 6 h of ischemia, and the protein expression was significantly increased at 1 d and 3 d after ischemia ( P < 0.05 ). Conclusion. By detecting the expression changes of Hesl+factor VII in the ischemic area, the results show that ischemia and hypoxia activate the HIF-1, making the HIF-l the main regulatory pathway in the process of angiogenesis after ischemia.

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Effects of Hypoxia-Inducible Factor 1 (HIF-1) Signaling Pathway on Acute Ischemic Stroke

Tao

2022

Computational and Mathematical Methods in Medicine

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Editorial Comment: Evaluation of HIF-1α and VEGF-A expression in radiation-induced cystitis: A case-control study

Cited by 1 publication

References 9 publications

Effects of Hypoxia-Inducible Factor 1 (HIF-1) Signaling Pathway on Acute Ischemic Stroke

Effects of Hypoxia-Inducible Factor 1 (HIF-1) Signaling Pathway on Acute Ischemic Stroke

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