The relationship of neutrophil to lymphocyte ratio with testicular cancer

Abstract

Purpose: To assess the relationship between testicular germ cell tumors (TGCT) and neutrophil to lymphocyte ratio (NLR) and to determine whether this ratio can be used as a serum tumor marker. Material and Methods: Sixty-one patients with testicular germ cell tumors were included into the study. Patients were grouped as localized and non-localized. Histologically patients were categorized as seminoma and nonseminomatous germ cell tumors. Complete blood cell count was measured the day before surgery and at the postoperative 1st month. Preoperative and postoperative mean NLR values were compared. Results: Thirty-six patients (59%) had seminomas and 25 patients (41%) had nonseminomatous testicular cancer. Forty-fi ve patients (73.8%) had localized and 16 patients (26.2%) had non-localized testicular cancer. There was a statistically signifi cant difference between preoperative and postoperative mean NLR of the localized patients (p=0.001) but no such difference was detected for non-localized patients (p=0.576). Nineteen patients with localized seminomas had normal preoperative serum tumor markers. There was a signifi cant difference between preoperative and postoperative mean NLR in this group of patients (p=0.010). Twenty-six patients with localized tumors had preoperative increased serum tumor markers which normalized after orchiectomy. Mean NLR of these patients signifi cantly decreased from 3.10±2.13 to 1.62±0.59 postoperatively (p=0.010).Conclusions: NLR appears to be a useful marker for TGCT. It is successful in predicting localized and non-localized disease in early postoperative period.

Nötrofil Lenfosit Oranı Evre 1 Testis Tümörünün Okkült Metastaz Parametrelerinde Bir Markır Olabilir mi?

“…In some studies in which the NLR threshold value was investigated, it was found to be 2.25 by Gokcen et al [16], 3.16 by Sahin et al [3] and 2.11 by Ilktac et al [19]. In our study, we have specified the NLR cut-off value as 2.27, which is in accordance with the literature.…”

The effects of vitamin B12, vitamin D, ferritin level, neutrophil/monocyte ratio and some blood parameters on genital warts presence, the number of lesions, and recurrence rates

“…The reason for such studies depends on the results of some laboratory studies in which cytokines that stimulate the secretion of neutrophils from the bone marrow are secreted from tumour cells. Therefore, the number and ratios of leucocytes (neutrophils, monocytes and lymphocytes), which play an important role in the host's immune response against infections and tissue damage, have attracted attention in some studies (Bashaw et al., 2017; Huang et al., 2015; De Felice et al., 2019; Ilktac et al., 2020; Dupin, 2004; Brentjens et al., 2002).…”

The Effects of Vitamin B12, Vitamin D, Ferritin Level, Neutrophil/Monocyte Ratio and Some Blood Parameters on Genital Warts Presence, the Number of Lesions, and Recurrence

“…The reason for such studies depends on the results of some laboratory studies in which cytokines that stimulate the secretion of neutrophils from the bone marrow are secreted from tumor cells. Therefore, the number and ratios of leukocytes (neutrophils, monocytes, and lymphocytes), which play an important role in the host's immune response against infections and tissue damage, have attracted attention in some studies 1,5,[11][12][13] What does this article add? Some labratory studies have demonstrated that tumor cells may release cytokines that stimulate the release of neutrophils from the bone marrow, which results in an elevation of the leucocytes 5,19 .…”

“…The reason for such studies depends on the results of some laboratory studies in which cytokines that stimulate the secretion of neutrophils from the bone marrow are secreted from tumor cells. Therefore, the number and ratios of leukocytes (neutrophils, monocytes, and lymphocytes), which play an important role in the host's immune response against infections and tissue damage, have attracted attention in some studies 1,5,[11][12][13] .…”