Comparision effects of solifenacin, darifenacin, propiverine on ocular parameters in eyes: A prospective study

Abstract

Objective: To evaluate the effects of solifenacin, darifenacin, and propiverine on nasal-, subfoveal-, temporal choroidal thicknesses (NCT, SFCT, TCT), intraocular pressure (IOP) and pupil diameter (PD). Materials and Methods: Patients with overactive bladder (OAB) diagnosed according to The International Continence Society were administered with solifenacin, darifenacin or propiverine on a daily basis between November 2017 and May 2018. NCT, SFCT, TCT, IOP, and PD of these patients were measured and compared as initial, fourth and twelfth weeks. Results: A total of 165 patients (330 eyes) with OAB were evaluated. Solifenacin (n=140) signifi cantly reduced IOP from 17.30±2.72 mmHg to 16.67±2.56 mmHg (p=0.006) and 16.57±2.41 mmHg (p=0.002), at the fourth and twelfth weeks, respectively. Darifenacin (n=110) signifi cantly reduced NCT from 258.70±23.96 μm to 257.51±22.66 μm (p=0.002) and 255.36±19.69 μm (p=0.038), at the fourth and twelfth weeks, respectively. Propiverine (n=80) signifi cantly increased PD from 4.04±0.48 mm to 4.08±0.44 mm (p=0.009) and 4.09±0.45 mm (p=0.001), at the fourth and twelfth weeks, respectively. Conclusion: These fi ndings can help to decide appropriate anticholinergic drug choice in OAB patients. We fi nally suggest further well-designed randomized prospective studies with a larger population to evaluate the anticholinergic-related complications in eyes.

The effect of systemic and topical ophthalmic medications on choroidal thickness: A review

“…was associated with a transient increase in the nasal CT at 4 weeks of use but gradually regressed to pretreatment levels after 12 weeks of use. These changes in CT were limited to the nasal region 25 . Other nonselective anticholinergics such as propiverine have not been shown to affect CT 25 .…”

“…Anticholinergic treatments for overactive bladder prostate are typically administered chronically darifenacin was associated with decreased nasal CT after just 4 weeks of use, persisting until 12 weeks with continued usage 25 Solifenacin. was associated with a transient increase in the nasal CT at 4 weeks of use but gradually regressed to pretreatment levels after 12 weeks of use.…”

“…These changes in CT were limited to the nasal region. 25 Other nonselective anticholinergics such as propiverine have not been shown to affect CT. 25 No adverse reactions specific to the choroid have been reported.…”

Bladder Cancer highlighted

“…Dr. Ölçücü and collegues from Turkey ( 4 ) on page 185 evaluate the effects of solifenacin, darifenacin, and propiverine on nasal-, subfoveal-, temporal choroidal thicknesses (NCT, SFCT, TCT), intraocular pressure (IOP) and pupil diameter (PD) in a 165 patients with overactive bladder (OAB) and concluded that solifenacin significantly reduced IOP, darifenacin significantly reduced NCT and propiverine significantly increased PD in patients with OAB who had normal ophthalmologic examinations after the twelve weeks of treatment. These findings can help to decide appropriate anticholinergic drug choice in OAB medical treatment for patients with eye-related disorders.…”