Hematologic parameters and Neutrophil / Lymphocyte ratio in the prediction of urethroplasty success

Topaktaş, Ramazan; Ürkmez, Ahmet; Tokuç, Emre; Akyüz, Mehmet; Kutluhan, Musab Ali

doi:10.1590/s1677-5538.ibju.2018.0682

Cited by 9 publications

(10 citation statements)

References 22 publications

(22 reference statements)

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“…Another study reported that the probability of spontaneous fistula closure increased as the NLR value decreased in patients who developed pancreatic fistula after distal pancreatectomy [13]. Topaktas et al investigated the effect of NLR in predicting the recurrence of urethral stenosis after urethroplasty and reported that NLR was ineffective in predicting the recurrence of urethral stenosis [14]. In the present study, no difference was found in the NLR values of patients who developed UCF.…”

Section: Discussioncontrasting

confidence: 42%

Effect of Haematological Parameters in the Development of Urethrocutaneous Fistula After Hypospadias Surgery

Gümüş¹,

Demir²

2023

Cureus

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Investigation of the relationship between urethrocutaneous fistula (UCF) development and haematological parameters after hypospadias surgery was aimed for in this study. Patients who underwent tubularized incised plate urethroplasty between January 2015 and June 2021 with the diagnosis of distal hypospadias were included in the study. We divided the participants into two groups based on UCF development. We compared haematological parameters, including neutrophil, lymphocyte, and platelet counts; neutrophillymphocyte ratio (NLR); platelet-lymphocyte ratio (PLR); and systemic immune inflammation index (SII) values between the two groups. A total of 78 patients were included in the study. Of the patients, 11 developed UCF. The mean age of the patients was 74.9 ± 42.8 months. Catheter diameter, operation time, neutrophil counts, NLR, and SII values were similar between those with and without UCF (p > 0.05). However, the UCF group had significantly higher lymphocyte and platelet counts than those without UCF (p < 0.05). Moreover, the PLR value was significantly lower in the UCF group (p < 0.05). Patients who developed UCF post hypospadias surgery had a significant association with altered blood cell counts, including increased lymphocytes and decreased PLR rate. The PLR can be used as a biological marker for UCF development.

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Section: Discussioncontrasting

confidence: 42%

Effect of Haematological Parameters in the Development of Urethrocutaneous Fistula After Hypospadias Surgery

Gümüş¹,

Demir²

2023

Cureus

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“…The best of our knowledge, this study is the first study that evaluate the value or capacity of hematological parameters in predicting the complications of hypospadias repair in children. There are three studies that evaluated the impact of these parameters in recurrence of urethral stricture after surgical treatment in adults (10,11,22). Topaktas et al (22) had reported 117 adult cases with urethral stricture who underwent urethroplasty and assessed the correlation between the systemic inflammation markers and recurrence rate of urethral stricture after surgery.…”

Section: Discussionmentioning

confidence: 99%

“…There are three studies that evaluated the impact of these parameters in recurrence of urethral stricture after surgical treatment in adults (10,11,22). Topaktas et al (22) had reported 117 adult cases with urethral stricture who underwent urethroplasty and assessed the correlation between the systemic inflammation markers and recurrence rate of urethral stricture after surgery. They determined that neutrophil, lymphocyte counts, or their ratio are not the predictors for recurrence urethral stricture after urethroplasty.…”

Section: Discussionmentioning

confidence: 99%

Do preoperative leukocyte and neutrophil levels have a predictive value on the complications of hypospadias repair in children?

Akgül

Abidoğlu

Bakır

et al. 2022

Arch Ital Urol Androl

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Objective: Surgeons observed that the outcomes after the same repair technique in the same type of hypospadias performed by the same surgeon may be different. There may be some indeterminate factors that influence the results such as subclinical inflammation. Our study evaluated the predictor values of inflammatory hematologic parameters on the complications after hypospadias repair. Materials and methods: We retrospectively reviewed the data of patients who underwent hypospadias repair between January 2016 and January 2019 in our clinic. Age at surgery, hypospadias type, repair technique, complications were recorded. Patients who underwent Snodgrass repair by a single surgeon were included in the study while patients who underwent different techniques or procedures that were performed by other surgeons were excluded. The levels of white blood cell, neutrophil, lymphocyte, platelet and monocyte, the mean platelet volumes were recorded from blood test that were performed one day before surgery. Neutrophil-lymphocyte ratio (NLR), plateletlymphocyte ratio (PLR), and other parameters were analyzed to determine their relationship with complications after hypospadias surgery. Results: WBC and neutrophil levels were statistically higher in patients with complications (p = 0.006 and 0.017 respectively). Other hematological parameters were not different between patients with or without complications. To predict the complications, the WBC cutoff was 9500/mm3, the neutrophil cutoff was 3000/mm3. Conclusions: WBC and neutrophil values were statistically significant in predicting the complications after Snodgrass repair in patients with hypospadias. Our result determined no relation between complications and NLR, PLR.

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“…58 NLR was found not to predict stricture recurrence in patients undergoing urethroplasty. 61 Thus, while there has been significant interest in utilizing NLR and PLR to predict strictures in various clinical populations, the results have been mixed and more specific markers are needed to identify patients at risk.…”

Section: Urethral Strictures—fibroinflammatory Contributorsmentioning

confidence: 99%

The contribution of the immune system to genitourinary fibrosis

Doersch

Barnett

Chase

et al. 2022

Exp Biol Med (Maywood)

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Fibrotic diseases of the genitourinary tract are devastating and incompletely understood pathologies. These diseases include urethral and ureteral strictures, retroperitoneal fibrosis, and Peyronie’s disease. They can contribute to obstructive uropathy and sexual dysfunction. Poor understanding of the pathophysiology of these diseases severely limits our ability to prevent and treat them. Genitourinary fibrotic diseases likely represent related pathologies that share common underlying mechanisms involving wound healing in response to injury. These diseases share the common feature of extracellular matrix abnormalities—such as collagen deposition, transforming growth factor-β accumulation, and dysregulation of collagen maturation—leading to abnormal tissue stiffness. Given the association of many of these diseases with autoimmunity, a systemic pro-inflammatory state likely contributes to their associated fibrogenesis. Herein, we explore the immunologic contribution to fibrogenesis in several fibrotic diseases of the genitourinary system. Better understanding how the immune system contributes to fibrosis in these diseases may improve prevention and therapeutic strategies and elucidate the functions of immunologic contributors to fibrosis in general.

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Hematologic parameters and Neutrophil / Lymphocyte ratio in the prediction of urethroplasty success

Cited by 9 publications

References 22 publications

Effect of Haematological Parameters in the Development of Urethrocutaneous Fistula After Hypospadias Surgery

Effect of Haematological Parameters in the Development of Urethrocutaneous Fistula After Hypospadias Surgery

Do preoperative leukocyte and neutrophil levels have a predictive value on the complications of hypospadias repair in children?

The contribution of the immune system to genitourinary fibrosis

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