Testicular mixed germ cell tumor presenting with seizure as the initial symptom: a case report and literature review

Abstract

Most patients with testicular germ cell tumor present with a painless scrotal mass. We report a 19-year-old patient who presented with neurological complains. Rapid clinical progression to coma was noted during the staging work up. A diagnosis of testicular mixed germ cell tumor with multiorgan metastasis (lymph node, lung, liver and brain) was made. Patients with brain metastasis should receive chemotherapy alone or combined with surgery or radiotherapy. Because the clinical symptoms deteriorated quickly, surgery was used upfront followed by chemotherapy and radiotherapy for the brain tumor. After the first stage of treatment, the clinical symptoms, tumor markers and imaging findings were improved. The residual brain tumor was eliminated by chemotherapy, and only sparse degenerated tumor cells were noted in the brain tissue. Longer follow up is required to assess the impact of our treatment strategy.

Metástasis gástrica de tumor de células germinales mixto primario testicular: reporte de caso

“…Según Globocan (2018), la incidencia de cáncer de testículo es de 0,4 % (5) . Sin embargo, en el Registro de cáncer de Lima Metropolitana se reporta que esta neoplasia fue la más frecuente en hombres del grupo etario cuyas edades fluctúan entre 15 y 29 años (2) , y el tumor de células germinales del tipo no seminomatoso fue el tipo más prevalente (4) . Es habitual que el principal síntoma sea un aumento de volumen del testículo, aunque en el 10 % de los pacientes el síntoma inicial suele estar relacionado con manifestaciones en el lugar de la metástasis (3) .…”

“…Los tumores de células germinales del testículo pueden ser seminomatoso y no seminomatoso (TCGNS), que es el más frecuente. Los TCGNS se definen como una proliferación tumoral maligna de tejido embrionario (carcinoma embrionario o teratoma) y/o extraembrionario (tumor vitelino y coriocarcinoma), y tienen un pronóstico desfavorable (4) . Aproximadamente en la mitad de los pacientes los TCGNS se manifiestan en un estadio avanzado.…”

Pure embryonal carcinoma of the testis in an adult male patient: case report

“…It is rarely seen in infants and those older than 50 years [1][2][3][4][5]. The cases generally apply to the clinic with complaints of painfree testicular mass and (10%) hormonal symptoms [1][2][3]10]. In approx.…”

“…For this reason, early diagnosis and treatment of embryonal carcinoma cases are very important [3]. As in many testicular tumors, embryonal carcinoma is also detected by the patient or coincidentally in examination in form of pain-free or (less frequently) painful palpable mass [5][6][7][8][9][10]. When pain or mass is detected in testis, the first imaging method to be used is USG.…”

Simultaneous intracranial and testicular germ cell tumors: illustrative case

“…Syu et al reported a case of testicular GCT with initial symptoms of seizure and metastases to the lymph nodes, lungs, liver, and brain. 11 Consequently, there are two possible etiologies for these simultaneous intracranial and testicular GCTs, including independent primary tumor and metastatic tumor. GCTs most commonly originate from the gonads, and extragonadal GCTs account for only about 3% to 7% of all GCTs.…”