Prostate Cancer – Local Treatment after Radiorecurrence: HIFU – High-Intensity Focused Ultrasound

Zéqui, Stênio de Cássio; Mourão, Thiago Camelo; Guimarães, Gustavo Cardoso

doi:10.1590/s1677-5538.ibju.2018.03.03

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Fluid shear-induced killing of circulating tumor cells and adhesive cancer cells can also be explained by increased sensitivity to mechanical forces (Lien et al, 2013;Regmi et al, 2017). In addition, ultrasonic and shock-wave therapies have demonstrated that cancer cells are particularly sensitive, although concerns were raised about increased metastasis and healthy tissue damage (Lin et al, 2012;Marano et al, 2017;Nicolai et al, 1994;Zequi et al, 2018). We designed this study to investigate the effect of mechanical cyclic stretch on the behavior of normal versus transformed cancer cells from a variety of different tissue backgrounds.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Stretch Kills Transformed Cancer Cells

Tijore

Yao

Wang

et al. 2018

Preprint

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Transformed cancer cells differ from normal cells in several important features like anchorage independence, Warburg effect and mechanosensing. Consequently, transformed cancer cells develop an anaplastic morphology and respond aberrantly to external mechanical forces.Consistent with altered mechano-responsiveness, here we show that transformed cancer cells from many different tissues have reduced growth and become apoptotic upon cyclic stretch as do normal cells after the transformation. When matrix rigidity sensing is restored in transformed cancer cells, they survive and grow faster on soft surface upon cyclic stretch like normal cells but undergo anoikis without stretch by activation of death associated protein kinase1 (DAPK1). In contrast, stretch-dependent apoptosis (mechanoptosis) of transformed cells is driven by stretchmediated calcium influx and calcium-dependent calpain 2 protease activation on both collagen and fibronectin matrices. Further, mechanosensitive calcium channel, Piezo1 is needed for mechanoptosis. Thus, cyclic stretching of transformed cells from different tissues activates apoptosis, whereas similar stretching of normal cells stimulates growth.

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Section: Introductionmentioning

confidence: 99%

Mechanical Stretch Kills Transformed Cancer Cells

Tijore

Yao

Wang

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

Selective killing of transformed cells by mechanical stretch

et al. 2021

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A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing

Sheetz

2019

Annu. Rev. Cell Dev. Biol.

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For many years, major differences in morphology, motility, and mechanical characteristics have been observed between transformed cancer and normal cells. In this review, we consider these differences as linked to different states of normal and transformed cells that involve distinct mechanosensing and motility pathways. There is a strong correlation between repeated tissue healing and/or inflammation and the probability of cancer, both of which involve growth in adult tissues. Many factors are likely needed to enable growth, including the loss of rigidity sensing, but recent evidence indicates that microRNAs have important roles in causing the depletion of growth-suppressing proteins. One microRNA, miR-21, is overexpressed in many different tissues during both healing and cancer. Normal cells can become transformed by the depletion of cytoskeletal proteins that results in the loss of mechanosensing, particularly rigidity sensing. Conversely, the transformed state can be reversed by the expression of cytoskeletal proteins—without direct alteration of hormone receptor levels. In this review, we consider the different stereotypical forms of motility and mechanosensory systems. A major difference between normal and transformed cells involves a sensitivity of transformed cells to mechanical perturbations. Thus, understanding the different mechanical characteristics of transformed cells may enable new approaches to treating wound healing and cancer.

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Prostate Cancer – Local Treatment after Radiorecurrence: HIFU – High-Intensity Focused Ultrasound

Cited by 3 publications

References 17 publications

Mechanical Stretch Kills Transformed Cancer Cells

Mechanical Stretch Kills Transformed Cancer Cells

Selective killing of transformed cells by mechanical stretch

A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing

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