Role of Adiponectin in prostate cancer

Hu, Cong; Zhang, Caiping; Zhang, Min; Long, Shiyin; Cao, Zhijian

doi:10.1590/s1677-5538.ibju.2018.0261

Cited by 23 publications

(15 citation statements)

References 51 publications

(63 reference statements)

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“…The mixed kinetic control of these two steps gives Tafel slopes in the range 60-120 mV dec −1 . This allowed interpreting the OER on Ti/IrO 2 -Ta 2 O 5 in H 2 SO 4 [57] , in which Tafel slopes of 59 and 130 mV dec −1 were reported for low and high current densities. The experimental curves fitted well in the low j range with a Tafel slope of 60 mV dec −1 when steps (8) and (9) were slow with respect to steps (5)- (7).…”

Section: Mechanism and Performancementioning

confidence: 92%

“…In the acidic solution, the following reactions were generally proposed as the mechanism for oxygen evolution on active oxide electrodes [10,55,57,58] :…”

Section: Mechanism and Performancementioning

confidence: 99%

“…When it is reaction (5) (dissociation of the O -H bond in the S-OH group), the Tafel slope is 40 mV dec −1 . In the case of reaction (6) (recombination of S-OH) and 7 http://engine.scichina.com/doi/10.1016/j.jechem.2019.03.008 However, Tafel slopes in the range 60-120 mV dec −1 were reported in several papers in the literature [10,48,55,[57][58][59] . To explain these values, a change was introduced in the mechanism, consisting in decomposing step (4) into the following two steps [55,57] :…”

Section: Mechanism and Performancementioning

confidence: 99%

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Supporting IrO2 and IrRuO nanoparticles on TiO2 and Nb-doped TiO2 nanotubes as electrocatalysts for the oxygen evolution reaction

Genova-Koleva

Alcaide

Álvarez

et al. 2019

Journal of Energy Chemistry

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Section: Mechanism and Performancementioning

confidence: 92%

“…In the acidic solution, the following reactions were generally proposed as the mechanism for oxygen evolution on active oxide electrodes [10,55,57,58] :…”

Section: Mechanism and Performancementioning

confidence: 99%

Section: Mechanism and Performancementioning

confidence: 99%

See 1 more Smart Citation

Supporting IrO2 and IrRuO nanoparticles on TiO2 and Nb-doped TiO2 nanotubes as electrocatalysts for the oxygen evolution reaction

Genova-Koleva

Alcaide

Álvarez

et al. 2019

Journal of Energy Chemistry

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“…As we have shown that adiponectin is a strong radioprotector for normal fibroblast cell populations it is of concern that it may also protect cancer cells from radiation damage. It has been shown in patients with prostate or colorectal cancers, as well as in the particular cancer cell lines used in this study (PC3 and HT29), that these tumor cells express receptors for adiponectin [45][46][47][48] . There is a wealth of published research showing adiponectin may actually have anti-tumor properties.…”

Section: Discussionmentioning

confidence: 80%

Adipocytes protect fibroblasts from radiation-induced damage by adiponectin secretion

Kosmacek

Oberley‐Deegan

2020

Sci Rep

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Prostate and colon cancers are among the most common cancers diagnosed annually, and both often require treatment with radiation therapy. Advancement in radiation delivery techniques has led to highly accurate targeting of tumor and sparing of normal tissue; however, in the pelvic region it is anatomically difficult to avoid off-target radiation exposure to other organs. Chronically the effects of normal urogenital tissue exposure can lead to urinary frequency, urinary incontinence, proctitis, and erectile dysfunction. Most of these symptoms are caused by radiation-induced fibrosis and reduce the quality of life for cancer survivors. We have observed in animal models that the severity of radiation-induced fibrosis in normal tissue correlates to damaged fat reservoirs in the pelvic region. We hypothesize that adipocytes may secrete a factor that prevents the induction of radiation-associated fibrosis in normal tissues. In these studies we show that the adipokine, adiponectin, is secreted by primary mouse adipocytes and protects fibroblasts from radiation-induced cell death, myofibroblast formation, and senescence. Further, we demonstrated that adiponectin does not protect colorectal or prostate cancer cells from radiation-induced death. Thus, we propose that adiponectin, or its downstream pathway, would provide a novel target for adjuvant therapy when treating pelvic cancers with radiation therapy. Radiation is used to treat a variety of pelvic cancers, including prostate and colorectal cancers. While radiation is an effective tool to treat these cancers, radiation also damages surrounding normal tissues. The chronic side effects of radiation treatment are similar for either prostate or colorectal cancer and include: urinary frequency, urinary incontinence, proctitis, erectile dysfunction, and bowel fibrosis 1-4. Most of these long-term side-effects are due to radiation-induced fibrosis. Fibroblasts are the cell type that is most studied in the context of radiation-induced fibrosis. In particular, fibroblasts, which function to maintain normal extracellular matrix (ECM) by producing proteins such as collagen and fibronectin, can become chronically activated after radiation exposure 5. Activated fibroblasts, or myofibroblasts, are initiated by ionizing radiation that activates the TGFβ pathway and chronic production of reactive oxygen species (ROS), which ultimately produces aberrant amounts of ECM 6-8. Irradiation of fibroblasts in normal tissue can lead to cell death, fibroblast activation, or cellular senescence, all of which can produce long term side effects including inflammation, fibrosis, and chronic tissue dysfunction 5,9. There are other cell types involved in fibrosis besides fibroblasts. Immune cells can provide a pro-fibrotic niche to activate fibroblasts and cause epithelial to mesenchymal transformation 10-12. Additionally, the pelvic region contains a large depot of visceral and subcutaneous adipose tissue. The role of adipocytes in radiationinduced fibrosis is unknown. Previously we have published ...

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“…Therefore, adipokine levels may be useful for cancer diagnosis and prognosis. On the other hand, changes in the secretion of adipokines have been reported to be closely associated with prostate cancer (Fryczkowski et al, 2018;Hu et al, 2019).…”

Section: Can the Irisin Be A Biomarker For Prostate Cancer? A Case Comentioning

confidence: 99%

Can the Irisin be a Biomarker for Prostate Cancer? A Case Control Study

Aslan

Hakan

Eryılmaz

et al. 2020

Asian Pac J Cancer Prev

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Aim: There is much evidence of an association between cancer and irisin that is an adipokine. This study researched on the relationship between prostate cancer (PCa) and irisin levels, and whether irisin can be used as a biomarker in the diagnosis of PCa. Materials and Methods: For the study groups, 50 primary PCa patients and 30 healthy male subjects were included in the PCa and healthy control groups, respectively. All volunteers in the healthy control group were screened for prostate cancer and other malignancies and chronic diseases. Volunteers who were determine to be completely healthy were included for healthy control group. In the serum samples of the subjects were measured free PSA, total PSA and irisin levels. Irisin levels were compared separately in terms of the Gleason scores and T stage. In addition to intergroup comparisons, the ROC curve for the irisin was plotted and power analysis was performed. Results: Free and total PSA levels in the PCa group were significantly higher compared to the healthy control group (p<0.05). In addition, irisin levels in the PCa group were significantly lower than in the healthy control group (p<0.05). There was no significant difference between irisin levels in the groups classified in terms of Gleason scores (p>0.05). When the cutoff value was taken as 8.1, the sensitivity and specificity of irisin for PCa were as 80.5% and 90%, respectively. Conclusion: The results of this study indicate that the levels of irisin in the PCa group are considerably reduced and irisin may be used as a biomarker as well as free and total PSA.

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Role of Adiponectin in prostate cancer

Cited by 23 publications

References 51 publications

Supporting IrO2 and IrRuO nanoparticles on TiO2 and Nb-doped TiO2 nanotubes as electrocatalysts for the oxygen evolution reaction

Supporting IrO2 and IrRuO nanoparticles on TiO2 and Nb-doped TiO2 nanotubes as electrocatalysts for the oxygen evolution reaction

Adipocytes protect fibroblasts from radiation-induced damage by adiponectin secretion

Can the Irisin be a Biomarker for Prostate Cancer? A Case Control Study

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