The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury

Karagöz, Mehmet Ali; Doluoğlu, Ömer Gökhan; Ünverdǐ, Hatǐce; Reşorlu, Berkan; Sunay, Mehmet Melih; Demirbaş, Arif; Karakan, Tolga; Aydın, Arif

doi:10.1590/s1677-5538.ibju.2017.0600

Cited by 11 publications

(7 citation statements)

References 26 publications

(27 reference statements)

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“…Papaverine an opioid analogs can relieve the spasm of vascular smooth muscle [28]. It is mainly used to treat ischemia caused by spasm of blood vessels of the heart, brain and peripheral.…”

Section: Discussionmentioning

confidence: 99%

Papaverine adjuvant therapy for microcirculatory disturbance in severe ulcerative colitis complicated with CMV infection: a case report

Tian

Zheng

Dong

et al. 2019

Clin J Gastroenterol

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Ulcerative colitis has hypercoagulable state and high risk of thrombosis; so mucosal disturbance of microcirculation may be mediate and amplify the inflammation of ulcerative colitis. A 56-year-old female patient was admitted in hospital for discontinuously mucous bloody stool for more than 1 year. Ulcerative colitis was determined after colonoscopy and pathologic examination. Mesalazine was effective during the year, but her symptoms recurred three times due to her bad compliance. One month before admission, the patient had severe recurrence after mesalazine withdrawal. At this time, the result of quantitative fluorescence PCR of colonic histic CMV-DNA was 1.6 × 104 copies/mL positive, CMV colitis was accompanied. After 4 weeks of ganciclovir and 6 weeks of mesalazine usage and nutrition support, the symptoms of diarrhea and abdominal cramp did not improve; stool frequency was more than twenty times a day. Probe-based confocal laser endomicroscopy revealed local microcirculation disturbance. Papaverine 90-mg slow drip for at least 10 h a day was added. The symptoms dramatically disappeared after 3 days of papaverine treatment. The patient had yellow mushy stool 2–3 times a day. Pathological findings showed diffuse submucosal hemorrhage and transparent thrombosis in capillaries. Treatment of microcirculatory disturbance in severe UC is a promising adjuvant therapy. Confocal laser endomicroscopy may be an effective method for microcirculation judgment.

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“…Papaverine an opioid analogs can relieve the spasm of vascular smooth muscle [28]. It is mainly used to treat ischemia caused by spasm of blood vessels of the heart, brain and peripheral.…”

Section: Discussionmentioning

confidence: 99%

Papaverine adjuvant therapy for microcirculatory disturbance in severe ulcerative colitis complicated with CMV infection: a case report

Tian

Zheng

Dong

et al. 2019

Clin J Gastroenterol

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“… . [ 153 ] Rat model Suture 4 h Scrotal incision 14 days Papaverine and alprostadil During detorsion Spermatic cord 20 mg/kg and 20 μg/kg respectively Papaverine and alprostadil protected against I/R testicular injury. [ 154 ] Rat model Suture 2 h Scrotal incision 4 h Trapidil 1 h post ischemia Intraperitoneal 40 mg/kg Trapidil attenuated I/R-induced oxidative stress and histological damage in the ipsilateral twisted testis.…”

Section: Pharmacological Potentials In the Management Of I/r Injurymentioning

confidence: 99%

Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models

Akhigbe,

Odetayo,

Akhigbe

et al. 2024

Heliyon

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“…Papaverine hydrochloride is equally as effective as sodium diclofenac for the short-term relief of acute renal colic pain, and it may be advantageous in patients with contraindications according to a prospective, single-blind clinical study that involved 86 patients with acute renal colic who were given 120 mg intravenous papaverine hydrochloride [ 101 ]. Another study found that the injection of alprostadil and papaverine into the spermatic cord protected against ischemia/reperfusion injury following right-side testes torsion and reduced histological alterations following testicular ischemia-reperfusion injury [ 102 ].…”

Section: Pharmacological Properties Of Papaverinementioning

confidence: 99%

Papaverine: A Miraculous Alkaloid from Opium and Its Multimedicinal Application

et al. 2023

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The pharmacological actions of benzylisoquinoline alkaloids are quite substantial, and have recently attracted much attention. One of the principle benzylisoquinoline alkaloids has been found in the unripe seed capsules of Papaver somniferum L. Although it lacks analgesic effects and is unrelated to the compounds in the morphine class, it is a peripheral vasodilator and has a direct effect on vessels. It is reported to inhibit the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) phosphodiesterase in smooth muscles, and it has been observed to increase intracellular levels of cAMP and cGMP. It induces coronary, cerebral, and pulmonary artery dilatation and helps to lower cerebral vascular resistance and enhance cerebral blood flow. Current pharmacological research has revealed that papaverine demonstrates a variety of biological activities, including activity against erectile dysfunction, postoperative vasospasms, and pulmonary vasoconstriction, as well as antiviral, cardioprotective, anti-inflammatory, anticancer, neuroprotective, and gestational actions. It was recently demonstrated that papaverine has the potential to control SARS-CoV-2 by preventing its cytopathic effect. These experiments were carried out both in vitro and in vivo and require an extensive understanding of the mechanisms of action. With its multiple mechanisms, papaverine can be considered as a natural compound that is used to develop therapeutic drugs. To validate its applications, additional research is required into its precise therapeutic mechanisms as well as its acute and chronic toxicities. Therefore, the goal of this review is to discuss the major studies and reported clinical studies looking into the pharmacological effects of papaverine and the mechanisms of action underneath these effects. Additionally, it is recommended to conduct further research via significant pharmacodynamic and pharmacokinetic studies.

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The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury

Cited by 11 publications

References 26 publications

Papaverine adjuvant therapy for microcirculatory disturbance in severe ulcerative colitis complicated with CMV infection: a case report

Papaverine adjuvant therapy for microcirculatory disturbance in severe ulcerative colitis complicated with CMV infection: a case report

Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models

Papaverine: A Miraculous Alkaloid from Opium and Its Multimedicinal Application

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