Analysis of the association between bladder carcinoma and arsenic concentration in soil and water in southeast Brazil

Abstract

In approximately 50% of cases of bladder carcinoma, an associated predisposing factor can be established. The main factors are exposure to tobacco, arsenic (As) ore and aromatic compounds. Arsenic is a metalloid with a low average concentration in the earth's crust, and one of the most dangerous substances for human health. The present study aims to evaluate the incidence of hospitalization and mortality from bladder neoplasia and its possible association with As concentration in water and soil in two of the most critical regions of Brazil: the states of São Paulo and Minas Gerais.We have investigated bladder cancer hospitalization and mortality in the states of Sao Paulo and Minas Gerais during 2010-2014. Water and soil samples were analyzed and As concentrations were established. Data were obtained through the Department of Informatics of the Brazilian Unified Health System. Correlation was made with water samples from São Paulo and with data on soil analysis from Minas Gerais.The results revealed no direct association in the distinctive municipalities. Areas with high environmental As concentration had a low bladder cancer rate, while areas with normal as levels had similar cancer rates. The quantitative variables did not present a normal distribution (p < 0.05).In conclusion, we did not observe a correlation between as concentration in water or soil and bladder cancer's hospitalization and mortality rates in the states of São Paulo and Minas Gerais.

Bladder cancer trends and mortality in the brazilian public health system

“…Metal workers, painters, rubber industry and textile workers and cement or mine workers are professionals with higher risk for BC due to exposure to polycyclic aromatic hydrocarbons (12,13).…”

A comparative meta andin silicoanalysis of differentially expressed genes and proteins in canine and human bladder cancer

“…In dogs, urothelial carcinoma is the most common malignant tumor in canine bladder, representing 1% of all neoplasms that affect dogs (Patrick et al, 2006). In humans, TCC is a tumor associated with several factors such as cigarette smoking, occupational exposure (Myasaki and Nishiyama, 2017), arsenic and aromatic compounds (Cha et al, 2018). In household dogs, a case-control study was previously performed to correlate cigarette smoke, obesity, use of topical insecticides and chemicals used at home with canine bladder cancer development (Glickman et al 1989).…”

A Comparative Meta-Analysis and in silico Analysis of Differentially Expressed Genes and Proteins in Canine and Human Bladder Cancer

“…In dogs, urothelial carcinoma is the most common malignant tumor in the canine bladder, representing 1% of all neoplasms that affect dogs ( 6 ). In humans, TCC is a tumor associated with several factors, such as cigarette smoking, occupational exposure ( 7 ), arsenic, cyclophosphamide, arylamines, and polycyclic aromatic hydrocarbons ( 8 ). In pet dogs, a case–control study was previously performed to correlate cigarette smoke, obesity, and use of topical insecticides and chemicals used at home with canine bladder cancer development ( 9 ).…”