Ureteral orifice involvement by urothelial carcinoma: long term oncologic and functional outcomes

Altok, Muammer; Şahin, Ali Feyzullah; Gökçe, Mehmet İlker; Ekin, Gökhan; Divrik, Rauf Taner

doi:10.1590/s1677-5538.ibju.2017.0218

Cited by 10 publications

(11 citation statements)

References 18 publications

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“…IC is used in some very important applications, such as ozone and superoxide detection, pH indication in redox reactions, preparation of medicinal capsules, and colouring of food, beverage, and denim fabric products. 6 Also, IC is significantly used for a variety of treatments such as gastric cancer, 7 transurethral resection and vesicoureteral reflux by locating ureteral orifices (destroys muscle fibres, leading to upper tract urothelial carcinoma development), 8,9 obstetric surgery, and chemotherapy of hepatic tumours. 10 Some of the earlier reports revealed that the highest allowed range of IC in the normal living body is from 100 mg/kg to 300 mg/kg body weight.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Analysis of Indigo Carmine in Food and Water Samples Using a Poly(Glutamic Acid) Layered Multi-walled Carbon Nanotube Paste Electrode

Hareesha

Manjunatha

Amrutha

et al. 2021

Journal of Elec Materi

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Some colourants are hazardous to living organisms. Hence, a powerful and fast methodology is required for the analysis of those colourants in food and water samples. A modest electrochemically polymerised glutamic acid layered multi-walled carbon nanotube paste electrode [P(GA)LMWCNTPE] was functionalised for the sensing of indigo carmine (IC) by the differential pulse voltammetry (DPV) and cyclic voltammetry (CV) approaches. Within the optimised experimental conditions, the P(GA)LMWCNTPE holds an acceptable and high rate of electro-catalytic activity towards the redox behaviour of IC. The projected P(GA)LMWCNTPE shows a decent selectivity for IC in the presence of methyl orange. The modified sensor shows an acceptable linear growth between oxidative peak current and concentration in both CV and DPV methods with fine limit of detection values of 4.2 lM and 0.36 lM, respectively. Additionally, the developed sensor was effectively applied to detect IC in food and water samples. The morphological and surface activities of the modified and unmodified electrodes were determined through field emission scanning electron microscopy, electrochemical impedance spectroscopy, and CV techniques. The P(GA)LMWCNTPE requires a simple preparation procedure and is low-cost, with acceptable storage stability, sensitivity, and reproducibility.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Analysis of Indigo Carmine in Food and Water Samples Using a Poly(Glutamic Acid) Layered Multi-walled Carbon Nanotube Paste Electrode

Hareesha

Manjunatha

Amrutha

et al. 2021

Journal of Elec Materi

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“…Taken together and based in the aforementioned studies [12,16,17], the rate of postoperative vesicoureteral obstruction rate due to a TURBT close to the ureteral orifice seems to be low and thus DJ stenting to protect the ureteral orifice eventually abdicable. However, these studies include only small cohorts.…”

Section: Discussionmentioning

confidence: 94%

“…Altok et al also retrospectively investigated TURBTs for BCa including the ureteral orifice (n = 138) [17]. There was no DJ stenting in this cohort.…”

Section: Discussionmentioning

confidence: 99%

“…Postoperative hydronephrosis occurred in 19.5% of the patients without preoperative hydronephrosis due to vesicoureteral reflux (47%), disease progression including the ureteral orifice (29%), urolithiasis (3%), and vesicoureteral obstruction (6%; n = 1). Therefore, the authors recommended against routine DJ stenting during TURBT of the ureteral orifice [17].…”

Section: Discussionmentioning

confidence: 99%

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Impact of double J stenting or nephrostomy placement during transurethral resection of bladder tumour on the incidence of metachronous upper urinary tract urothelial cancer

et al. 2020

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Background: Whether or not double J (DJ) stenting during transurethral resection of a bladder tumour (TURBT) harms patients with regard to possible metachronous upper urinary tract urothelial cancer (UUTUC) development remains controversial. This study evaluated the impact of DJ compared to nephrostomy placement during TURBT for bladder cancer (BCa) on the incidence of metachronous UUTUCs. Methods:We retrospectively analysed 637 patients who underwent TURBT in our department between 2008 and 2016. BCa, UUTUC and urinary drainage data (retrograde/anterograde DJ and percutaneous nephrostomy) were assessed, along with the prevalence of hydronephrosis, and mortality. Chi-square and Fisher's exact test was performed for univariate analyses. Survival analysis was performed by the Kaplan-Meier method and log-rank tests.Results: UUTUC was noted in 28 out of 637 patients (4.4%), whereas only eight (1.3%) developed it metachronously to BCa. Out of these, four patients received DJ stents, while four patients received no urinary drainage of the upper urinary tract. Placement of urinary drainage significantly correlated with UUTUC (50.0% vs. 17.9%; p = 0.041). DJ stenting significantly correlated with UUTUC (50.0% vs. 11%; p < 0.01), while no patient with a nephrostomy tube developed UUTUC. UUTUC-free survival rates were significantly lower for patients with DJ stents than for all other patients (p = 0.001). Patients with or without DJ stents had similar overall survival (OS) rates (p = 0.73), whereas patients with nephrostomy tubes had significantly lower OS rates than all other patients (p < 0.001). Conclusions: Patients with DJ stenting during TURBT for BCa might have an increased risk of developing metachronous UUTUC. This study indicated advantages in placing nephrostomy tubes rather than DJ stents; however, confirmation requires investigation of a larger cohort. Even so, the increased mortality rate in the nephrostomy group reflected hydronephrosis as an unfavourable prognostic factor.

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“…[20]. This phenomenon might be caused by the loss of the anti-re ux mechanism after resected the ori ce, and thus the tumor cells seeded to the upper urinary tract [21]. However, Mano et al reported their outcomes in 65 patients, which revealed only one patient was diagnosed with recurrent tumor in the upper urinary tract after transurethral resection of bladder tumor from ureteral ori ce, and their conclusion suggested that ureteral ori ce resection was not very relevant with an increased risk of tumor recurrence in the upper urinary tract [22].…”

Section: Discussionmentioning

confidence: 99%

Frequency and Clinicopathological Features of Distant Metastasis of Bladder Cancer: A SEER-Based Study

Miao

Wei

Cui

et al. 2021

Preprint

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Background: bladder cancer (BCa) is a common malignancy in the urinary system. But the hematogenous metastatic pattern of it was poorly explored. The aim of this study was to provide a better understanding of the prognosis of the different distant metastatic pattern from stage IV BCa patients and support for making a suitable clinical decision.Methods: The Surveillance, Epidemiology and End Result database (SEER) provided data for this study include BCa from 2010 to 2015. Kaplan–Meier method was used to evaluate the survival prognosis of patients of metastatic BCa. Cox proportional hazards regression model was utilized to analyzed risk factors. All statistical tests were two-sided.Results: At the time of diagnosis, a total of 6808 eligible patients at stage IV were extracted from SEER database. Patients who suffered metastasis to either one of the four sites occupied 25.31% (1723/6808) of BCa. Bone was the most common distant metastatic site of BCa (1225 cases), and brain metastases had the worst prognosis whose mean survival was 6.282 months. The results of univariate survival analysis presented that diagnostic age, race, gender, primary site surgery, tumor size, T stage, N stage, primary tumor site, histology, marital status and metastatic number were independent prognostic factors affecting overall survival (OS) (P<0.05). On multivariable Cox regression, squamous cell carcinoma was an independent risk factor affecting the overall survival (P < 0.05). The nomogram model was constructed to show the 1-, 3- and 5-year survival rates of patients.Conclusion: In analysis of single metastatic sites, patients with brain metastasis had the worst overall survival and lung metastasis had the best outcomes than other three distant metastases. Knowledge of these differences in metastatic patterns is helpful for clinicians to make better pre-treatment evaluation and clinical decisions.

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Ureteral orifice involvement by urothelial carcinoma: long term oncologic and functional outcomes

Cited by 10 publications

References 18 publications

Electrochemical Analysis of Indigo Carmine in Food and Water Samples Using a Poly(Glutamic Acid) Layered Multi-walled Carbon Nanotube Paste Electrode

Electrochemical Analysis of Indigo Carmine in Food and Water Samples Using a Poly(Glutamic Acid) Layered Multi-walled Carbon Nanotube Paste Electrode

Impact of double J stenting or nephrostomy placement during transurethral resection of bladder tumour on the incidence of metachronous upper urinary tract urothelial cancer

Frequency and Clinicopathological Features of Distant Metastasis of Bladder Cancer: A SEER-Based Study

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