OAB score: A clinical model that predicts the probability of presenting overactive detrusor in the urodynamic study

Abstract

PurposeTo create a predictive model of involuntary detrusor contraction (IDC) to improve the diagnostic accuracy of overactive detrusor (OAD), associating overactive bladder (OAB) symptoms with other clinical parameters in the female population.Materials and MethodsA total of 727 women were studied retrospectively. In all of them, urodynamic study was conducted for urogynecological causes. Demographics information, personal history, symptoms, physical exam, a 3-day frequency/volume chart and urinary culture, were collected in all patients and they subsequently underwent uroflowmetry and urodynamic studies. A logistic regression model was performed in order to determine independent predictors of presence of IDC. Odd ratio (OR) estimation was used to assign a score to each one of the significant variables (p≤0.05) in the logistic regression model. We performed a ROC curve in order to determine the predictive ability of the score in relation to the presence of OAD.Resultspresence of OAD was evident in 210 women (29%). In the logistic regression analysis, independent predictors of OAD were urgency, urgency incontinence, nocturia, absence of SUI symptoms, diabetes mellitus, reduction of vaginal trophism and bladder capacity below 150 mL. The probability of IDC diagnosis increases as the score raises (Score 0: 4% until Score ≥10: 88%). Sensitivity was 71% and specificity 72%. The area under the curve of OAB score was 0.784 (p>0.001).ConclusionsOAB score is a clinical tool that shows higher diagnostic accuracy than OAB symptoms alone to predict overactive detrusor.

Exploring biomarkers in the overactive bladder: Alterations in miRNA levels of a panel of genes in patients with OAB

“…The combination of let-7b-5p + miR-98-5p + miR-139-5p and the combination of let-7b-5p + miR-98-5p also had high diagnostic performance values with AUC of 0.836 and 0.801, respectively. The AUC value for the OAB symptom score, which is the most commonly used method in the diagnosis of OAB, was reported as 0.842 by Chuang et al 27 in their most recent study, and as 0.78 in a study by Aribillaga et al 28 Dysregulation of all these miRNAs has not been previously reported as a diagnostic marker for OAB. When the findings are evaluated, a combination of miR-98-5p + miR-139-5p or miR-98-5p alone can be used as effective biomarkers in the diagnosis of OAB.…”

Cough associated detrusor overactivity in women with urinary incontinence

“…There is some evidence to suggest an association between the severity of urgency symptoms and the presence of detrusor overactivity. 26 It is noteworthy that women with Type III also had the longest duration of phasic contraction (39.6 s). We speculate that the higher degree of bother in Type III CADO might be associated with the longer duration of phasic CADO contraction in these women.…”

“…Women with Type III CADO showed a significantly higher degree of bother when assessed by the PPBC scale. There is some evidence to suggest an association between the severity of urgency symptoms and the presence of detrusor overactivity . It is noteworthy that women with Type III also had the longest duration of phasic contraction (39.6 s).…”

ADRB3, ROCK2, and GEF Levels in Overactive Bladder Patients

“…The ADRB3+ROCK2+GEF combination and the ADRB3+ROCK2 combination also had a substantial ability to differentiate patients from healthy controls, with AUCs of 0.752 and 0.700, respectively. For the OAB symptom score, which is the most commonly used method to diagnose OAB, Chuang et al [ 16 ] and Arribillaga et al [ 17 ] reported AUC values of 0.842 and 0.78, respectively. Therefore, ROC analysis suggested that ROCK2, especially in combination with GEF or ADRB3, could act as an auxiliary biomarker for the diagnosis of OAB.…”