Acquired Hemophilia presenting as Gross hematuria following Kidney Stone – A case report and review of the literature

Schmidt-Bowman, Max; Reinstatler, Lael; Raffin, Eric; Yared, Joseph; Seigne, John D.; Sverrisson, Einar F.

doi:10.1590/s1677-5538.ibju.2017.0172

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…The case report of AHA presenting as persistent gross hematuria underscores the importance of considering AHA in the differential diagnosis of unexplained bleeding, especially in atypical presentations [ 11 ]. This highlights the need for increased awareness among healthcare professionals on the diverse clinical manifestations of AHA, as early recognition is crucial for timely intervention and improved patient outcomes [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Challenges and Management of Acquired Hemophilia A Presenting as Gross Hematuria: A Case Report

Kaltsas,

Zachariou,

Kratiras

et al. 2023

Cureus

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Acquired hemophilia A (AHA) is a rare autoimmune disorder marked by autoantibodies against coagulation factor VIII, leading to bleeding complications. This case report explores a unique presentation of AHA, initially manifested as gross hematuria, a symptom often encountered in healthcare settings with a broad range of differential diagnoses. The background of this study highlights the rarity of AHA and its diverse clinical presentations. The case involves a 62-year-old man with no history of bleeding disorders, presenting with gross hematuria and later developing severe anemia and ecchymoses. Methods employed in the evaluation included urological assessments such as cystoscopy and computed tomography, alongside hematological investigations, which later revealed a prolonged activated partial thromboplastin time (aPTT) and a critically low factor VIII level, indicative of AHA. Results showed a lack of early recognition of coagulation abnormalities, underscoring the need for comprehensive initial assessments in cases of unexplained hematuria. The patient's management at a specialized Hemophilia Center involved inhibitor eradication therapy and management of acute bleeding episodes, resulting in significant clinical improvement. The conclusions drawn from this case emphasize the importance of considering rare conditions like AHA in the differential diagnosis of hematuria and the necessity for a broad diagnostic approach. It advocates for heightened awareness and early coagulation studies in unexplained cases of hematuria to prevent delayed diagnoses and improve patient outcomes. This case contributes to the understanding of AHA's clinical variability and the critical nature of early and comprehensive diagnostic approaches in hematuria evaluation.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Challenges and Management of Acquired Hemophilia A Presenting as Gross Hematuria: A Case Report

Kaltsas,

Zachariou,

Kratiras

et al. 2023

Cureus

View full text Add to dashboard Cite

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“…So, in most of the patient Renal colic, hematuria [6] [7] and a positive at plain film X-ray is a typical presentation for 90% of people who show up with Urolithiasis some people can have vague abdominal pain that it's kind of like some other abdominal inflammation for example diverticulitis or appendicitis and then some people will have real acute abdominal pain and flank pain, nausea, vomiting can be seen urinary urgency and frequency and penile and testicular pain are also symptoms that can show up in a presentation.…”

Section: Introductionmentioning

confidence: 99%

The Role of Imaging in Diagnosis of Urolithiasis and Nephrolithiasis—A Literature Review Article

Gupta¹,

Li²,

Ji³

et al. 2019

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Urolithiasis or nephrolithiasis is a common ailment in the emergency room. The clinical presentation of a kidney stone includes fever, nausea, vomiting, acute flank pain radiating to the groin or the back. The pain is often described as stabbing and there is tachycardia, with or without hematuria for the severe patient. For the triad for urinary or kidney stones, some people say they are fever, vomiting, and acute flank pain. So in acute setting analgesia is given with or without an antiemetic to prevent vomiting IV fluids administered carefully. Noncontrast computed tomography (CT) is the gold standard for diagnosis. Most of urinary stones get washouts spontaneously if it is less than 5 mm without any intervention. However, if intervention is required either it is done by elective or as soon as possible by the intervention. I mean surgical management and surgical management will depend on how big the kidney stone is in there as well as where the kidney stone is if it is within the ureter or within the actual kidney.

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Acquired Hemophilia presenting as Gross hematuria following Kidney Stone – A case report and review of the literature

Cited by 2 publications

References 7 publications

Diagnostic Challenges and Management of Acquired Hemophilia A Presenting as Gross Hematuria: A Case Report

Diagnostic Challenges and Management of Acquired Hemophilia A Presenting as Gross Hematuria: A Case Report

The Role of Imaging in Diagnosis of Urolithiasis and Nephrolithiasis—A Literature Review Article

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