Nephrogenic adenoma of the bladder: a single institution experience assessing clinical factors

Yi, Ya Sha; Wu, Angela; Cameron, Anne P.

doi:10.1590/s1677-5538.ibju.2017.0155

Cited by 11 publications

(14 citation statements)

References 18 publications

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“…The most important limitation of our study is the narrow case series. However, the majority of large case series and current literature indicate that nephrogenic adenoma is a benign reactive lesion and is not associated with the development of bladder cancer (18).…”

Section: Discussionmentioning

confidence: 99%

Nephrogenic adenomas of the urinary system: a clinicopathologic analysis of 30 cases

et al. 2021

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Objective: Nephrogenic adenomas (NA) are benign lesions that may occur in several sites throughout the urinary tract, from the renal pelvis to urethra, and especially in the bladder. They are strongly associated with urinary tract irritation, chronic inflammation, previous urologic surgery, and intravesical instrumentations. Our study aims to evaluate and present the clinicopathologic characteristics and findings of cases that were diagnosed with nephrogenic adenoma accompanied by relevant information from the literature. Material and Methods: Our study includes 30 patients who were pathologically diagnosed with NA from February 2005 to November 2017. Results: Among these patients, 63.3% were males and mean age was 60 years. The most common site of occurrence was the bladder (86.6%), followed by the ureter (6.7%) and the urethra (6.7%). Most patients presented with hematuria (36.7%). History of concurrent bladder cancer was present in 26.7% of patients, but there were no cases of de novo bladder cancer diagnosed after NA. Recurrence of NA after initial resection occurred in only 10% of patients who underwent follow-up cystoscopy. Nephrogenic adenoma is a rare lesion associated with nonspecific symptoms and endoscopic features. Definite diagnosis must be made after histological analysis of resected specimens. Conclusion: Nephrogenic adenoma is a rare lesion associated with nonspecific symptoms and nonspesific endoscopic features. A definite diagnosis must be after histological analysis of resected specimens. Keywords: nephrogenic adenoma, urothelial lesion, bladder, ureter

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Section: Discussionmentioning

confidence: 99%

Nephrogenic adenomas of the urinary system: a clinicopathologic analysis of 30 cases

et al. 2021

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“…These may mimic other urologic conditions, such as chronic cystitis or urothelial carcinoma. Most commonly, nephrogenic adenoma presents with lower urinary tract symptoms, such as hematuria, retention, dysuria or recurrent urinary tract infections [10] .…”

Section: Discussionmentioning

confidence: 99%

Nephrogenic adenoma of the ureter in a teenager with history of leukemia

Koberlein

Munden

2021

Radiology Case Reports

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Nephrogenic adenomas represent a suspected metaplastic response of the uroepithelium to chronic inflammation and are typically associated with recurrent urinary tract infections, stones, prior radiation therapy and other irritative factors, more commonly seen in adults. Nephrogenic adenoma (also known as nephrogenic metaplasia) usually involves the bladder in adults and represents a rare lesion that can easily be misdiagnosed as a malignancy. We present the case of a 14-year-old male with prior history of acute lymphoblastic leukemia (ALL) who presented with a several month history of vague flank pain which increased in intensity, leading to an emergency department presentation with the only significant finding on exam being microhematuria. Subsequent imaging showed a tumor like replacement of the right ureter with proximal hydronephrosis, initially felt to represent recurrent leukemia. Pathology revealed the tumor like ureteral replacement to represent a nephrogenic adenoma, a benign entity which often responds to conservative management, though not previously reported in the ureter in pediatrics.

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“…Since the first report of NA in 1949, physicians have debated the origin of the cells that constitute this peculiar lesion and their potential to transform into malignancy [ 1 – 5 ]. Various theories have been put forward about the origin of the cells including metaplasia secondary to chronic irritation, such as infection and instrumentation, or developmental anomaly in the embryological structures giving rise to the genitourinary tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Nephrogenic adenoma (NA) is an uncommon lesion of the lower urinary tract which is found most commonly in the urinary bladder [ 1 ]. It presents macroscopically as a polypoid tumor, single or multiple, discovered in patients who usually have hematuria but can be asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

Nephrogenic Adenoma of the Urinary Bladder after Kidney Transplantation: Long-Term Follow-Up

Khan

Obeid

Hasan

et al. 2020

Case Reports in Transplantation

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Nephrogenic adenoma is a rare lesion that consists of epithelial cells arranged in tubular form, resembling tubules in the renal medulla, and is found usually in the urinary bladder although it can occur anywhere in the transitional epithelium of the lower urinary tract. The first case of nephrogenic adenoma of the urinary bladder was reported before the first kidney transplantation, and the lesion has been reported in patients with and without renal transplantation. The origin of cells in nephrogenic adenoma is debated and has been postulated to arise from cells of embryonic origin or from metaplasia secondary to chronic irritation or from implantation of allograft cells in patients with kidney transplantation. The long-term outcome and potential to convert into malignancy are not established, and therefore, there are no recommendations on how to follow up these patients. We present a case of a patient who was found to have nephrogenic adenoma of the urinary bladder during his second kidney transplantation from a cadaveric donor. He had undergone living donor kidney transplantation previously which subsequently failed. The patient did not manifest any symptoms of nephrogenic adenoma. During a follow-up period of 5 years, he has not manifested any symptoms related to nephrogenic metaplasia. Histopathological examination 5 years after the second transplantation did not show any malignant change. It can be concluded that nephrogenic adenoma is likely to behave in benign fashion post kidney transplantation.

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Nephrogenic adenoma of the bladder: a single institution experience assessing clinical factors

Cited by 11 publications

References 18 publications

Nephrogenic adenomas of the urinary system: a clinicopathologic analysis of 30 cases

Nephrogenic adenomas of the urinary system: a clinicopathologic analysis of 30 cases

Nephrogenic adenoma of the ureter in a teenager with history of leukemia

Nephrogenic Adenoma of the Urinary Bladder after Kidney Transplantation: Long-Term Follow-Up

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