Low serum Insulin Like Growth Factor - 1 in patients with Stress Urinary Incontinence

Abstract

Objective:SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in women. Recent animal study has shown that there are therapeutic effects of Insulin-like growth factors (IGF-1) on stress urinary incontinence in rats with simulated childbirth trauma. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues and stimulates fibroblast proliferation and enhances collagen synthesis. The purpose of the current study was to determine the association between IGF-1 levels and SUI.Materials and Methods:All patients were evaluated for SUI and divided into two groups: 116 women with SUI and 76 women without SUI. Diagnosis of SUI was based on the International Consultation on Incontinence Questionnaire-Short Form (ICIQSF). Levels of IGF-1 were measured in serum by enzyme-linked immunosorbent assay. The relationship between IGF-1 levels and SUI in patients was evaluated statisticaly.Results:The mean age of patients wiyh SUI was 49.9±8.6 and 48.7±7.8 in control group. Plasma IGF-1 levels were significantly lower in SUI than in control group (106.5±26.4 and 133.3±37.1ng/mL, respectively, P <0.001). Body mass indexes were higher in women with SUI than women without SUI.Conclusion:In this study lower serum IGF-1 levels were found to be associated with SUI. Serum IGF-1 level appears to be a specific predictor of SUI, and it may be used in early prediction of SUI in female population.

Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies

“…All studies included women and female animals only. Of the human studies, SUI alone was investigated in 52 human studies [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ], and SUI with the co-occurrence of POP in 23 studies [ 62 , 72 , 73 , 74 ...…”

The Sequencing of the Insulin-like Growth Factor 1 and Fibulin 5 Gene Variants in the Pre and Post-menopausal Women with Stress Urinary Incontinence

“…It has also been reported that IGF1 stimulates fibroblast proliferation, increases collagen synthesis (13), and accelerates the growth and differentiation of striated muscle precursor cells in the human urethral sphincter (14). Furthermore, it was shown that low serum IGF1 levels were found associated with SUI (15). The IGF1 rs6214 variation is a three prime untranslated region (3'-UTR/ G>A) polymorphism.…”