Renal Cell Carcinoma and Visceral Adipose Index: a new risk parameter

Ötünçtemur, Alper; Dursun, Murat; Ozer, Kutan; Horsanalı, Ozan; Özbek, Emin

doi:10.1590/s1677-5538.ibju.2015.0396

Cited by 8 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly to FLI, VAI is associated with MetS ( 26 ) and several metabolic diseases, including type 2 diabetes mellitus ( 27 ). Of interest, both FLI and VAI have been used in several studies as predictors of incident cancer ( 28 – 31 ). In particular, in a very recent study, high FLI values have been reported to predict NAFLD and breast cancer risk in postmenopausal women ( 29 ), while in a population-based longitudinal study VAI was reported as a predictor of incident colorectal cancer ( 32 ).…”

Section: Introductionmentioning

confidence: 99%

Cardio-Metabolic Indices and Metabolic Syndrome as Predictors of Clinical Severity of Gastroenteropancreatic Neuroendocrine Tumors

Barrea

Muscogiuri²,

Modica³

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundObesity, mainly visceral obesity, and metabolic syndrome (MetS) are major risk factors for the development of type 2 diabetes, cardiovascular diseases, and cancer. Data analyzing the association of obesity and MetS with gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are lacking. Fatty liver index (FLI) is a non-invasive tool for identifying individuals with non-alcoholic fatty liver disease (NAFLD). Visceral adiposity index (VAI) has been suggested as a gender-specific indicator of adipose dysfunction. Both indexes have been proposed as early predictors of MetS. This study aimed to investigate the association of FLI VAI as early predictors of MetS with gastroenteropancreatic neuroendocrine tumors (GEP-NETs).MethodsA cross-sectional, case–control, observational study was carried out at the ENETS Centers of Excellence Multidisciplinary Group for Neuroendocrine Tumors, University “Federico II”. VAI and FLI were calculated.ResultsWe enrolled 109 patients with histologically confirmed G1/G2 GEP-NET (53 M; 57.06 ± 15.96 years), as well as 109 healthy subjects, age, sex- and body mass index-matched. Forty-four GEP-NET patients were G2, of which 21 were with progressive disease, and 27 patients had metastases. GEP-NET patients had a higher value of VAI (p < 0.001) and FLI (p = 0.049) and higher MetS presence (p < 0.001) compared with controls. VAI and FLI values and MetS presence were higher in G2 than in G1 patients (p < 0.001), in patients with progressive disease, and in metastatic vs non-metastatic patients (p < 0.001). In addition, higher values of VAI and FLI and higher MetS presence were significantly correlated with the worst clinical severity of NENs. The cut-off values for the FLI and MetS to predict high grading of GEP-NETs and the presence of metastasis were also provided.ConclusionsThis is the first study investigating an association between VAI and FLI as early predictors of MetS and GEP-NET. Our findings report that the worsening of clinicopathological characteristics in GEP-NET is associated with higher presence of MetS, NAFLD, evaluated by FLI, and visceral adiposity dysfunction, evaluated by VAI. Addressing the clinical evaluation of MetS presence, NAFLD, and visceral adiposity dysfunction might be of crucial relevance to establish targeted preventive and treatment interventions of NEN-related metabolic comorbidities.

show abstract

Section: Introductionmentioning

confidence: 99%

Cardio-Metabolic Indices and Metabolic Syndrome as Predictors of Clinical Severity of Gastroenteropancreatic Neuroendocrine Tumors

Barrea

Muscogiuri²,

Modica³

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Controversy still exists on the relationship between VATI and clinical outcomes in patients with solid tumors. [10,[22][23][24] The reasons whereby SATI appears to hold a stronger association with OS over VATI in our study remain to be elucidated. However, it is notable that-differently from visceral fat (which is an active endocrine organ)-subcutaneous fat is more strictly involved in lipid and energy storage and is characterized by a lower inflammatory environment [14,25,26].…”

Section: Discussionmentioning

confidence: 69%

“…[6] Subcutaneous and visceral adipose tissue indices (SATI and VATI, respectively) may influence the clinical outcomes of patients with cancer in a sex-dependent manner. [7] Previous studies have reported a significant prognostic impact of SATI and VATI in different solid tumors, including advanced renal cell carcinoma, hepatocellular carcinoma, and pancreatic cancer, [8][9][10] although there has been some discrepant findings and the therapeutic implications of these observations have not been fully elucidated [11].…”

Section: Introductionmentioning

confidence: 99%

Association of subcutaneous and visceral adipose tissue with overall survival in Taiwanese patients with bone metastases – results from a retrospective analysis of consecutively collected data

et al. 2020

View full text Add to dashboard Cite

Background Growing evidence indicates that measures of body composition may be related to clinical outcomes in patients with malignancies. The aim of this study was to investigate whether measures of regional adiposity-including subcutaneous adipose tissue index (SATI) and visceral adipose tissue index (VATI)-can be associated with overall survival (OS) in Taiwanese patients with bone metastases. Methods This is a retrospective analysis of prospectively collected data. We examined 1280 patients with bone metastases who had undergone radiotherapy (RT) between March 2005 and August 2013. Body composition (SATI, VATI, and muscle index) was assessed by computed tomography at the third lumbar vertebra and normalized for patient height. Patients were divided into low-and high-adiposity groups (for both SATI and VATI) according to sexspecific median values.

show abstract

“…As such, this organization also suggests that the measurement of VFA via MRI or CT scanning is more precise as a means of defining abdominal obesity. Otunctemur et al determined that visceral fat is a significant predictor of tumour grade and size in ccRCC patients [ 25 ], and such correlations have also been confirmed for small RCC [ 26 ]. One multicenter study conducted in China revealed ccRCC patients’ visceral fat to be predictive of RCC pathological subtype [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stage

et al. 2021

View full text Add to dashboard Cite

Although much is known about how adipose tissue affects the development of clear cell renal carcinoma (ccRCC), little information is available for the utility of sex-specific abdominal visceral fat composition as a predictor of clear cell renal carcinoma (ccRCC) T stage. We conducted CTbased sex-specific abdominal fat measurements in ccRCC patients to assess whether VFA distribution could predict the ccRCC T stage. In total, 253 patients (182 males and 71 females) from our hospital with pathologically confirmed ccRCC (178 low T-stage and 75 high T-stage) were retrospectively reviewed for the present study. Computed tomography (CT) scans were assessed using ImageJ to differentiate between the visceral and subcutaneous fat areas (VFA and SFA), after which the relative VFA (rVFA) and total fat area (TFA) were computed. The relationships between these fat area-related variables, patient age, sex, and BMI, and ccRCC T stage were then evaluated through univariate and multivariate logistic regression analysis to clarify the association between general or sex-specific abdominal visceral fat and T stage. Following adjustment for age, males with high T stage ccRCC exhibited an increased rVFA as compared to males with low T stage ccRCC, with the same relationship being observed among females. This association between rVFA and high T stage was confirmed through both univariate and multivariate models. As thus, sexspecific visceral fat composition is a reliable independent predictor that can identify both male and female patients with high T stage ccRCC.

show abstract

Renal Cell Carcinoma and Visceral Adipose Index: a new risk parameter

Cited by 8 publications

References 28 publications

Cardio-Metabolic Indices and Metabolic Syndrome as Predictors of Clinical Severity of Gastroenteropancreatic Neuroendocrine Tumors

Cardio-Metabolic Indices and Metabolic Syndrome as Predictors of Clinical Severity of Gastroenteropancreatic Neuroendocrine Tumors

Association of subcutaneous and visceral adipose tissue with overall survival in Taiwanese patients with bone metastases – results from a retrospective analysis of consecutively collected data

The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stage

Contact Info

Product

Resources

About