The influence of distal colon irritation on the changes of cystometry parameters to esophagus and colon distentions

Abstract

The co-occurrence of multiple pathologies in the pelvic viscera in the same patient, such as, irritable bowel syndrome and interstitial cystitis, indicates the complexity of viscero-visceral interactions and the necessity to study these interactions under multiple pathological conditions. In the present study, the effect of distal colon irritation (DCI) on the urinary bladder interaction with distal esophagus distention (DED), distal colon distention (DCD), and electrical stimulation of the abdominal branches of vagus nerve (abd-vagus) were investigated using cystometry parameters. The DCI significantly decreased the intercontraction time (ICT) by decreasing the storage time (ST); nonetheless, DED and Abd-vagus were still able to significantly decrease the ICT and ST following DCI. However, DCD had no effect on ICT following the DCI. The DCI, also, significantly decreased the Intravesical pressure amplitude (P-amplitude) by increasing the resting pressure (RP). Although DED has no effect on the P-amplitude, both in the intact and the irritated animals, the abd-vagus significantly increased the P-amplitude following DCI by increasing the maximum pressure (MP). In the contrary, 3mL DCD significantly increased the P-amplitude by increasing the MP and lost that effect following the DCI. Concerning the pressure threshold (PT), none of the stimuli had any significant changes in the intact animals. However, DCI significantly decreased the PT, also, the abd-vagus and 3mL DCD significantly decreased the PT. The results of this study indicate that chemical irritation of colon complicates the effects of mechanical irritation of esophagus and colon on urinary bladder function.

Effect of distal esophageal irritation on the changes of cystometry parameters to esophagus and colon distentions in rats

“…The effect of DED is consistent with our previous results on non-irritated animals (Kaddumi et al 2012). On the other hand, electrical stimulation of vagus nerve didn't have an effect on the micturition frequency, although it was able to do so in the intact non-irritated animals (Kaddumi 2016b), which indicates that DEI obscured the effect of vagal inputs in changing the micturition frequency. Although the present study was conducted on male rats, gender and hormonal treatment effects on the viscero-visceral interaction could be tested on future studies.…”

“…Then, cystometry recordings in each animal were done for ten minutes with each stimulus and ten minutes off stimulus (Kaddumi 2016b).…”

“…On the other hand, chemical irritation of distal colon significantly affected the bladder function by increasing the bladder frequency. It, also, complicated the effect of mechanical distal colon and esophageal stimuli on the urinary bladder function (Kaddumi 2016b). However, the effect of esophageal inflammation on the urinary bladder function or its interaction with other viscera have not been studied yet.…”