Effect on hemostasis of an absorbable hemostatic gelatin sponge after transrectal prostate needle biopsy

Abstract

Objectives To examine the usefulness of an absorbable hemostatic gelatin sponge for hemostasis after transrectal prostate needle biopsy.Subjects and Methods The subjects comprised 278 participants who underwent transrectal prostate needle biopsy. They were randomly allocated to the gelatin sponge insertion group (group A: 148 participants) and to the non-insertion group (group B: 130 participants). In group A, the gelatin sponge was inserted into the rectum immediately after biopsy. A biopsy-induced hemorrhage was defined as a case in which a subject complained of bleeding from the rectum, and excretion of blood clots was confirmed. A blood test was performed before and after biopsy, and a questionnaire survey was given after the biopsy.Results Significantly fewer participants in group A required hemostasis after biopsy compared to group B (3 (2.0%) vs. 11 (8.5%), P=0.029). The results of the blood tests and the responses from the questionnaire did not differ significantly between the two groups. In multivariate analysis, only “insertion of a gelatin sponge into the rectum” emerged as a significant predictor of hemostasis.Conclusion Insertion of a gelatin sponge into the rectum after transrectal prostate needle biopsy significantly increases hemostasis without increasing patient symptoms, such as pain and a sense of discomfort.

The management of rectal bleeding following transrectal prostate biopsy: A review of the current literature

“…51 More recently, the insertion of a gelatin sponge into the rectum after biopsy increased haemostasis without increasing patient symptoms. 52 Park et al compared TRUS-guided compression on bleeding biopsy tracts immediately after prostate biopsy versus a noncompression group and found that rectal bleeding incidence was significantly lower in the compression group. 53…”

Capillary rise of non-aqueous liquids in cellulose sponges

“…An understanding of and prediction of the soaking and drying phenomena are relevant to various situations including food processing and preservation (Welti-Chanes, Velez-Ruiz & Barbosa-Canovas 2016), functional fabric design (Vasiliev 2008), landslides (Take et al 2004) and building safety (Šelih, Sousa & Bremner 1994). We also note that highly absorbent sponges are finding diverse medical applications including dressing, wound healing (Kobatake, Mita & Kato 2015;Lee et al 2016a) and dental treatments (Castro-Ceseña et al 2016), where liquid imbibition dynamics plays an important role.…”

Biodegradable Microporous Starch with Assembled Thrombin for Rapid Induction of Hemostasis

“…Ideally, hemostatic materials should control different degrees of bleeding within a short time and be blood-compatible, biocompatible, and biodegradable. − They should also possess high absorption capacity, which is determined by a porous structure or gel performance. Several materials have been investigated for their potential as hemostatic agents, including chitosan, , gelatin, , cellulose, − starch, montmorillonoid, zeolite, mesoporous silica, and alginate . The high porosity of mesoporous bioactive glass chitosan composite scaffold containing gallium promotes blood absorption and platelet aggregation to stem bleeding, but its efficacy has not been confirmed in vivo.…”