Beneficial effects montelukast, cysteinyl-leukotriene receptor antagonist, on renal damage after unilateral ureteral obstruction in rats

Abstract

Introductıon Ureteral obstruction is a common pathology and caused kidney fibrosis and dysfunction at late period. In this present, we investigated the antifibrotic and antiinflammatory effects of montelukast which is cysteinyl leukotriene receptor antagonist, on kidney damage after unilateral ureteral obstruction(UUO) in rats.Mateirıals and Methods 32 rats divided four groups. Group 1 was control, group 2 was sham, group 3 was rats with UUO and group 4 was rats with UUO which were given montelukast sodium (oral 10 mg/kg/day). After 14 days, rats were killed and their kidneys were taken and blood analysis was performed. Tubular necrosis, mononuclear cell infiltration and interstitial fibrosis scoring were determined histopathologically in a part of kidneys; nitric oxide(NO), malondialdehyde(MDA) and reduced glutathione(GSH) levels were determined in the other part of kidneys. Urea-creatinine levels were investigated at blood analysis. Statistical analyses were made by the Chi-square test and one-way analysis of variance (ANOVA).Results There was no difference significantly for urea-creatinine levels between groups. Pathologically, there was serious tubular necrosis and fibrosis in group 3 and there was significantly decreasing for tubular necrosis and fibrosis in group 4(p<0.005). Also, there was significantly increasing for NO and MDA levels; decreasing for GSH levels in group 3 compared the other groups(p<0.005).Conclusıon We can say that montelukast prevent kidney damage with antioxidant effect, independently of NO.

Protective effect of cysteinyl leukotriene receptor antagonist montelukast in bleomycin-induced pulmonary fibrosis

“…Sener et al [19] demonstrated that montelukast attenuated burn-induced oxidative injury of the skin and remote organs and reduced MDA and MPO with increased GSH levels in lung, liver, kidney and skin tissues. Similarly, Otunctemur et al [40] showed decreased tubular necrosis and fibrosis in montelukast received and ureteral obstructed rats. In our study, elevation of MDA and depletion of GSH contents following bleomycin administration were restored by montelukast in early-and late-term.…”

Ameliorating Effect of Pentadecapeptide Derived from Cyclina sinensis on Cyclophosphamide-Induced Nephrotoxicity

“…MDA, the final product of various lipid peroxides produced via lipid peroxidation, is a sensitive indicator of the level of free radical metabolism in the body [ 27 ]. In addition, acrolein (a toxic CTX metabolite) can increase the amount of reactive oxygen species (ROS) and can promote lipid peroxidation by combining with glutathione (GSH) [ 28 ]. Superoxide dismutase, CAT, and GSH-Px are the most common antioxidants that primarily inhibit or prevent formation of free radicals and ROS in vivo.…”

The Ameliorating Effect of Plasma Protein from Tachypleus tridentatus on Cyclophosphamide-Induced Acute Kidney Injury in Mice

“…Various stimulating factors in the body will result in oxidation stress due to an imbalance between antioxidant defense mechanisms and excessive production of reactive oxygen species (ROS). ROS can cause lipid breakdown through lipid peroxidation, and the level of MDA in the final products can reflect the severity of oxidative stress damage in tissue cells [16]. SOD, GSH-Px, and CAT are key antioxidant enzymes in the body and play important roles in the process of MDA elimination [17].…”