Serum Levels of Trace Elements in Patients with Testicular Cancers

Kaba, Mehmet; Pirinççi, Necip; Yüksel, Mehmet Bilgehan; Geçit, İlhan; Güneş, Mustafa; Demir, Murat; Akkoyun, HurremTuran; Demır, Halit

doi:10.1590/s1677-5538.ibju.2014.0460

Cited by 23 publications

(11 citation statements)

References 33 publications

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“…Although many researchers have observed increased Cu concentration in the sera of some cancer patients, such as testicular, oral, bladder (Mao and Huang, 2013;Baharvand et al, 2014a;Kaba et al, 2015), the present findings regarding SGTs did not reveal any difference in comparison to the normal subjects. One study reported lower Cu serum level in patients with colorectal cancer in comparison with normal individuals and found Cu deficiency in the population (Khoshdel et al, 2016).…”

Section: Statement Conflict Of Interestcontrasting

confidence: 76%

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Serum Levels of Zinc, Copper and Ferritin in Patients with Salivary Gland Tumors

Jaafari‐Ashkavandi

Khademi

Malekzadeh

et al. 2019

Asian Pac J Cancer Prev

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Background:Variation in serum levels of trace elements including zinc, copper and ferritin has been reported in cancer patients. The aim of this study was to evaluate these trace elements in the patients’ sera with benign and malignant salivary gland tumors (SGTs) and compare them with normal individuals.Methods:In this cross-sectional study, 60 patients with SGTs including 16 pleomorphic adenoma and 44 malignant SGTs, as well as 28 healthy controls, were enrolled. Serum levels of zinc, copper and ferritin were determined by atomic absorption and ELISA methods. Data were analyzed using one way ANOVA, Chi-square, Kruskal-Wallis and Mann- Whitney tests.Results:The mean concentration of zinc, copper, ferritin was1.5± 2 ppm, 1.2± 0.5 ppm, and 96.7± 65.7 ng/ml in PA, 1.5± 1.4,1.3± 0.4, and 111.2± 112 in malignant SGTs, and1.1±0.3, 1.2± 0.23 and 124±135.8 in normal control groups. There was no statistically significant difference between the patients and control groups, and between benign and malignant SGTs (P>0.05).Conclusion:The serum levels of trace elements in SGTs were not different from normal individuals. The results might have been affected by some interventional factors. Therefore, designing cohort complementary studies might result in obtaining more accurate data.

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Section: Statement Conflict Of Interestcontrasting

confidence: 76%

“…It is shown that Zn supplementation might reduce DNA damage and inflammation sources (Sun et al, 2016). In addition, some studies have shown increased Zn levels in oral and testicular cancer patients (Baharvand et al, 2014a;Kaba et al, 2015).…”

Section: Statement Conflict Of Interestmentioning

confidence: 99%

Serum Levels of Zinc, Copper and Ferritin in Patients with Salivary Gland Tumors

Jaafari‐Ashkavandi

Khademi

Malekzadeh

et al. 2019

Asian Pac J Cancer Prev

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“…Previous studies reported that there is a strong association between decreased concentration of serum selenium and zinc with various types of cancers such as ovarian, testicular, cervical, bladder and renal cancer. [7][8][9] Decreased amounts of the essential trace elements especially selenium and zinc were observed in post-therapy of cancer. 10 It is well documented that cancer patients often suffer from Vitamin deficiencies, especially of folic acid, Vitamin C and pyridoxine.…”

Section: Introductionmentioning

confidence: 99%

Antioxidants with Multivitamin and Mineral Supplementation Attenuates Chemotherapy or Radiotherapy-induced Oxidative Stress in Cancer Patients

Patil¹,

More²

2020

IJPER

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Aim:The present study was planned to evaluate the combined effects of antioxidant multivitamin and minerals (AMM) in reducing cancer and cancer therapy-induced oxidative stress. In addition cell viability of human malignant melanoma and normal mouse fibroblast cell lines after treatment with different concentrations of AMM and methotrexate were also estimated. Methods: Amongst the 120 cancer patients recruited for the study, 60 patients each were treated with radiotherapy and chemotherapy. In both radiotherapy and chemotherapy, 30 patients each were supplemented with AMM for 30 days. Thirty healthy human volunteers were recruited for comparison. On day 31, blood samples were collected for estimation of oxidative stress markers (MDA and nitrite), endogenous (SOD and GPx) and exogenous (Vitamin C and Vitamin E) antioxidants and essential trace elements (zinc, copper and selenium). In addition, cell viability of human malignant melanoma and normal mouse fibroblast cell lines were estimated after treatment with different concentrations of AMM and methotrexate. Results: Supplementation of AMM during cancer therapy minimized the burden of free reactive radicals and restored the endogenous and exogenous antioxidants and essential trace element levels. In addition, AMM has no cytotoxic effect on normal mouse fibroblast cell lines. But AMM imparts suppression of cell proliferation in human malignant melanoma. Conclusion: Supplementation of antioxidants with multivitamin and mineral during cancer therapy is found to be beneficial as they minimize the burden of free reactive radicals and restores the endogenous and exogenous antioxidants and essential trace element levels.

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“…Environmental trace elements including selenium (Se), zinc (Zn), copper (Cu), and iron (Fe) have been implicated in various types of cancer [11,12]. Studies have shown elevated levels of Cu in bladder, breast, prostate, and liver cancers [13], and the Cu/Zn ratio is used to assess patient prognosis [14,15]. Additionally, several studies showed that Zn supplement may protect against free radical damage [16] or that Zn levels are decreased in patients with certain malignancies [17].…”

Section: Introductionmentioning

confidence: 99%

Altered Trace Elements Levels in Hair of Prostate Cancer Patients

Saleh¹,

Adly²,

Nassir³

2017

J Cancer Sci Ther

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Background: Deficiency or excess of trace elements can induce metabolic disorders and dysregulate cell growth, and even lead to mutations and tumorigenesis. Many reports have indicated a direct association between micronutrient deficiency and cancer mortality. Prostate cancer is the sixth most common cancer among men in Saudi Arabia, yet there are few studies of the association between trace element levels and prostate cancer in the country.Objective: This study aimed to explore the association between concentrations of select hair trace elements, including selenium (Se), zinc (Zn), copper (Cu), manganese (Mn), and iron (Fe), as long-term indicators, and tumorigenesis of prostate cancer in Saudi Arabia. 1.2 Patients and Methods: The study included 58 patients with prostate cancer, 64 with benign prostatic hyperplasia (BPH), and 52 healthy controls. Full history and clinical data were recorded for all subjects. Hair samples were collected from the nape of all subjects, and levels of Se, Zn, Cu, Mn, and Fe were analyzed by inductively-coupled plasma mass spectrometry. Results:Hair Se and Zn levels of prostate cancer patients were significantly lower compared to BPH and healthy groups whereas Cu, Mn, and Fe levels were significantly high. Hair Se and Zn levels were significantly lower in metastatic prostate cancer patients than in localized cancer patients whereas mean hair levels of Cu, Mn, and Fe were not significantly different among these patients. Conclusion:Prostate cancer may be associated with trace element-mediated metabolic disorders. Low levels of Se and Zn and high levels of Cu, Mn, and Fe appear to be associated with its tumorigenesis. Additional prospective studies are warranted to confirm the inverse correlation between Se and Zn levels and prostate cancer.

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Serum Levels of Trace Elements in Patients with Testicular Cancers

Cited by 23 publications

References 33 publications

Serum Levels of Zinc, Copper and Ferritin in Patients with Salivary Gland Tumors

Serum Levels of Zinc, Copper and Ferritin in Patients with Salivary Gland Tumors

Antioxidants with Multivitamin and Mineral Supplementation Attenuates Chemotherapy or Radiotherapy-induced Oxidative Stress in Cancer Patients

Altered Trace Elements Levels in Hair of Prostate Cancer Patients

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